Ferulic acid exerts neuroprotective effects against cerebral ischemia/reperfusion-induced injury via antioxidant and anti-apoptotic mechanisms in vitro and in vivo

• Published in: International journal of molecular medicine Vol. 40; no. 5; pp. 1444 - 1456
• Main Authors: Ren, Zhongkun, Zhang, Rongping, Li, Yuanyuan, Li, Yu, Yang, Zhiyong, Yang, Hui
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.11.2017; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Adapter proteins; Animals; Antioxidants; Antioxidants - chemistry; Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; Brain injuries; Cardiovascular disease; Care and treatment; Cell Line; Cells, Cultured; Chinese medicine; Coumaric Acids - chemistry; Coumaric Acids - pharmacology; Disease Models, Animal; Drug dosages; ferulic acid; Free radicals; Gamma oryzanol; Glutathione Peroxidase - metabolism; Health aspects; Hippocampus - metabolism; Hippocampus - pathology; Hypoglycemia; Hypoxia; Ischemia; ischemia/reperfusion; Male; Malondialdehyde - metabolism; Memory - drug effects; Myeloid Differentiation Factor 88 - metabolism; Nervous system; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacology; neuroprotective effect; oxidation; Oxidative stress; Oxidative Stress - drug effects; Pyramidal Cells - drug effects; Pyramidal Cells - metabolism; Rats; Reactive Oxygen Species - metabolism; Reperfusion injury; Reperfusion Injury - drug therapy; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Rodents; Signal Transduction - drug effects; Studies; Substance abuse treatment; Toll-Like Receptors - metabolism

Ferulic acid (FA) is a derivative of cinnamic acid. It is used in the treatment of heart head blood-vessel disease and exerts protective effects against hypoxia/ischemia-induced cell injury in the brain. This study investigated the potential neuroprotective effects of FA against ischemia/reperfusion...