Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome

• Published in: Nature communications Vol. 11; no. 1; pp. 1363 - 13
• Main Authors: Li, Cai, Luscombe, Nicholas M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.03.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 45/23; 631/114; 631/181/735; 631/208/191; 631/208/737; 631/337/100/1701; Biological evolution; Computational Biology; Depletion; DNA Mismatch Repair; DNA Transposable Elements; DNA-Directed DNA Polymerase; Evolution, Molecular; Gene mapping; Genetic Variation; Genetics; Genome, Human; Genomes; Germ-Line Mutation; High resolution; Humanities and Social Sciences; Humans; Mismatch repair; multidisciplinary; Mutation; Mutation Rate; Mutation rates; Nucleosomes; Science; Science (multidisciplinary); Stability; Transposons

Nucleosome organization has been suggested to affect local mutation rates in the genome. However, the lack of de novo mutation and high-resolution nucleosome data has limited the investigation of this hypothesis. Additionally, analyses using indirect mutation rate measurements have yielded contradic...