Peropsin, a Novel Visual Pigment-Like Protein Located in the Apical Microvilli of the Retinal Pigment Epithelium

A visual pigment-like protein, referred to as peropsin, has been identified by large-scale sequencing of cDNAs derived from human ocular tissues. The corresponding mRNA was found only in the eye, where it is localized to the retinal pigment epithelium (RPE). Peropsin immunoreactivity, visualized by...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 94; no. 18; pp. 9893 - 9898
Main Authors Sun, Hui, Gilbert, Debra J., Copeland, Neal G., Jenkins, Nancy A., Nathans, Jeremy
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences of the United States of America 02.09.1997
National Acad Sciences
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The National Academy of Sciences of the USA
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Abstract A visual pigment-like protein, referred to as peropsin, has been identified by large-scale sequencing of cDNAs derived from human ocular tissues. The corresponding mRNA was found only in the eye, where it is localized to the retinal pigment epithelium (RPE). Peropsin immunoreactivity, visualized by light and electron microscopy, localizes the protein to the apical face of the RPE, and most prominently to the microvilli that surround the photoreceptor outer segments. These observations suggest that peropsin may play a role in RPE physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.
AbstractList A visual pigment-like protein, referred to as peropsin, has been identified by large-scale sequencing of cDNAs derived from human ocular tissues. The corresponding mRNA was found only in the eye, where it is localized to the retinal pigment epithelium (RPE). Peropsin immunoreactivity, visualized by light and electron microscopy, localizes the protein to the apical face of the RPE, and most prominently to the microvilli that surround the photoreceptor outer segments. These observations suggest that peropsin may play a role in RPE physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.
A visual pigment-like protein, referred to as peropsin, has been identified by large-scale sequencing of cDNAs derived from human ocular tissues.
Author Gilbert, Debra J.
Copeland, Neal G.
Jenkins, Nancy A.
Nathans, Jeremy
Sun, Hui
AuthorAffiliation Department of Molecular Biology and Genetics, § Department of Neuroscience, ¶ Department of Ophthalmology, ‡ Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and † Mammalian Genetics Laboratory, Advanced BioScience Laboratories Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702
AuthorAffiliation_xml – name: Department of Molecular Biology and Genetics, § Department of Neuroscience, ¶ Department of Ophthalmology, ‡ Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; and † Mammalian Genetics Laboratory, Advanced BioScience Laboratories Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702
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  givenname: Neal G.
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  surname: Jenkins
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/9275222$$D View this record in MEDLINE/PubMed
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To whom reprint requests should be addressed at: 805 PCTB, 725 North Wolfe Street, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
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Snippet A visual pigment-like protein, referred to as peropsin, has been identified by large-scale sequencing of cDNAs derived from human ocular tissues. The...
A visual pigment-like protein, referred to as peropsin, has been identified by large-scale sequencing of cDNAs derived from human ocular tissues.
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SourceType Open Access Repository
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Enrichment Source
Publisher
StartPage 9893
SubjectTerms Amino Acid Sequence
Amino acids
Antibodies
Biological Sciences
Cloning, Molecular
Deoxyribonucleic acid
DNA
DNA, Complementary - genetics
DNA, Complementary - isolation & purification
Eye Proteins - genetics
Eye Proteins - metabolism
Eyes & eyesight
Genetic loci
Humans
Microscopy, Immunoelectron
Microvilli
Microvilli - metabolism
Molecular Sequence Data
Photoreceptors
Pigment Epithelium of Eye - metabolism
Pigment Epithelium of Eye - ultrastructure
Proteins
Receptors
Retina
Retinal pigments
Retinal Pigments - genetics
Retinal Pigments - metabolism
Rhodopsin
Sequence Alignment
Ungulates
Vertebrates
Title Peropsin, a Novel Visual Pigment-Like Protein Located in the Apical Microvilli of the Retinal Pigment Epithelium
URI https://www.jstor.org/stable/43123
http://www.pnas.org/content/94/18/9893.abstract
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Volume 94
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