Yet another pattern recognition receptor involved in the chemotherapy-induced anticancer immune response: Formyl peptide receptor-1

Several pattern recognition receptors including toll-like receptors and purinergic receptors are implicated in the anticancer immune response elicited by anthracyclines or oxaliplatin. Recently, formyl peptide receptor-1 (FPR1) has been involved in this response as well. FPR1 is required for the cor...

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Bibliographic Details
Published inOncoimmunology Vol. 5; no. 5; p. e1118600
Main Authors Vacchelli, Erika, Ma, Yuting, Baracco, Elisa E., Zitvogel, Laurence, Kroemer, Guido
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 03.05.2016
Subjects
Annexin A1
apoptosis
Author's View
CTL
DAMPs
immunogenic cell death
Medicin och hälsovetenskap
apoptosis
CTL
Annexin A1
immunogenic cell death
DAMPs
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Summary:Several pattern recognition receptors including toll-like receptors and purinergic receptors are implicated in the anticancer immune response elicited by anthracyclines or oxaliplatin. Recently, formyl peptide receptor-1 (FPR1) has been involved in this response as well. FPR1 is required for the correct positioning of dendritic cells (DC) close to dying cancer cells. A genetic defect in FPR1 abrogates cross-presentation of tumor antigens by DC, thereby compromising therapy-elicited immunosurveillance.
Bibliography:ObjectType-Article-1
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ISSN:2162-4011
2162-402X
2162-402X
DOI:10.1080/2162402X.2015.1118600