Capabilities of multi-pinhole SPECT with two stationary detectors for in vivo rat imaging

• Published in: Scientific reports Vol. 10; no. 1; p. 18616
• Main Authors: Janssen, Jan P., Hoffmann, Jan V., Kanno, Takayuki, Nose, Naoko, Grunz, Jan-Peter, Onoguchi, Masahisa, Chen, Xinyu, Lapa, Constantin, Buck, Andreas K., Higuchi, Takahiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.10.2020; Nature Publishing Group
• Subjects: 692/308; 692/308/2778; 692/308/575; 692/53; 692/53/2421; Animals; Bone and Bones - diagnostic imaging; Computed tomography; Equipment Design - instrumentation; Equipment Design - methods; Heart; Heart Ventricles - diagnostic imaging; Humanities and Social Sciences; Image Processing, Computer-Assisted - instrumentation; Image Processing, Computer-Assisted - methods; Mice; multidisciplinary; Performance assessment; Phantoms, Imaging; Radioactive tracers; Rats; Science; Science (multidisciplinary); Sensors; Single photon emission computed tomography; Spatial discrimination; Technetium - administration & dosage; Technetium Tc 99m Sestamibi - administration & dosage; Tomography, Emission-Computed, Single-Photon - instrumentation; Tomography, Emission-Computed, Single-Photon - methods; Ventricle

We aimed to investigate the image quality of the U-SPECT5/CT E-Class a micro single-photon emission computed tomography (SPECT) system with two large stationary detectors for visualization of rat hearts and bones using clinically available 99m Tc-labelled tracers. Sensitivity, spatial resolution, un...