iPS cell technologies: significance and applications to CNS regeneration and disease

• Published in: Molecular brain Vol. 7; no. 1; p. 22
• Main Authors: Okano, Hideyuki, Yamanaka, Shinya
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.03.2014; BioMed Central
• Subjects: Animals; Central Nervous System - pathology; Central Nervous System - physiopathology; Central Nervous System Diseases - therapy; Humans; Induced Pluripotent Stem Cells - cytology; Kinases; Medical research; Medicine, Experimental; Nerve Regeneration; Regenerative Medicine - methods; Review; Science; Stem Cell Research; Stem cells; Studies; Technology; Transplantation; Japan

In 2006, we demonstrated that mature somatic cells can be reprogrammed to a pluripotent state by gene transfer, generating induced pluripotent stem (iPS) cells. Since that time, there has been an enormous increase in interest regarding the application of iPS cell technologies to medical science, in...