Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
Recently, nanocarriers that transport bioactive substances to a target site in the body have attracted considerable attention and undergone rapid progression in terms of the state of the art. However, few nanocarriers can enter the brain via a systemic route through the blood-brain barrier (BBB) to...
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| Published in | Nature communications Vol. 8; no. 1; pp. 1001 - 9 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
17.10.2017
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2041-1723 2041-1723 |
| DOI | 10.1038/s41467-017-00952-3 |
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| Abstract | Recently, nanocarriers that transport bioactive substances to a target site in the body have attracted considerable attention and undergone rapid progression in terms of the state of the art. However, few nanocarriers can enter the brain via a systemic route through the blood-brain barrier (BBB) to efficiently reach neurons. Here we prepare a self-assembled supramolecular nanocarrier with a surface featuring properly configured glucose. The BBB crossing and brain accumulation of this nanocarrier are boosted by the rapid glycaemic increase after fasting and by the putative phenomenon of the highly expressed glucose transporter-1 (GLUT1) in brain capillary endothelial cells migrating from the luminal to the abluminal plasma membrane. The precisely controlled glucose density on the surface of the nanocarrier enables the regulation of its distribution within the brain, and thus is successfully optimized to increase the number of nanocarriers accumulating in neurons.
There are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid glycaemic increase the accumulation of a glucosylated nanocarrier in the brain can be controlled. |
|---|---|
| AbstractList | There are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid glycaemic increase the accumulation of a glucosylated nanocarrier in the brain can be controlled. Recently, nanocarriers that transport bioactive substances to a target site in the body have attracted considerable attention and undergone rapid progression in terms of the state of the art. However, few nanocarriers can enter the brain via a systemic route through the blood-brain barrier (BBB) to efficiently reach neurons. Here we prepare a self-assembled supramolecular nanocarrier with a surface featuring properly configured glucose. The BBB crossing and brain accumulation of this nanocarrier are boosted by the rapid glycaemic increase after fasting and by the putative phenomenon of the highly expressed glucose transporter-1 (GLUT1) in brain capillary endothelial cells migrating from the luminal to the abluminal plasma membrane. The precisely controlled glucose density on the surface of the nanocarrier enables the regulation of its distribution within the brain, and thus is successfully optimized to increase the number of nanocarriers accumulating in neurons.There are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid glycaemic increase the accumulation of a glucosylated nanocarrier in the brain can be controlled. Recently, nanocarriers that transport bioactive substances to a target site in the body have attracted considerable attention and undergone rapid progression in terms of the state of the art. However, few nanocarriers can enter the brain via a systemic route through the blood-brain barrier (BBB) to efficiently reach neurons. Here we prepare a self-assembled supramolecular nanocarrier with a surface featuring properly configured glucose. The BBB crossing and brain accumulation of this nanocarrier are boosted by the rapid glycaemic increase after fasting and by the putative phenomenon of the highly expressed glucose transporter-1 (GLUT1) in brain capillary endothelial cells migrating from the luminal to the abluminal plasma membrane. The precisely controlled glucose density on the surface of the nanocarrier enables the regulation of its distribution within the brain, and thus is successfully optimized to increase the number of nanocarriers accumulating in neurons. Recently, nanocarriers that transport bioactive substances to a target site in the body have attracted considerable attention and undergone rapid progression in terms of the state of the art. However, few nanocarriers can enter the brain via a systemic route through the blood-brain barrier (BBB) to efficiently reach neurons. Here we prepare a self-assembled supramolecular nanocarrier with a surface featuring properly configured glucose. The BBB crossing and brain accumulation of this nanocarrier are boosted by the rapid glycaemic increase after fasting and by the putative phenomenon of the highly expressed glucose transporter-1 (GLUT1) in brain capillary endothelial cells migrating from the luminal to the abluminal plasma membrane. The precisely controlled glucose density on the surface of the nanocarrier enables the regulation of its distribution within the brain, and thus is successfully optimized to increase the number of nanocarriers accumulating in neurons.There are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid glycaemic increase the accumulation of a glucosylated nanocarrier in the brain can be controlled.Recently, nanocarriers that transport bioactive substances to a target site in the body have attracted considerable attention and undergone rapid progression in terms of the state of the art. However, few nanocarriers can enter the brain via a systemic route through the blood-brain barrier (BBB) to efficiently reach neurons. Here we prepare a self-assembled supramolecular nanocarrier with a surface featuring properly configured glucose. The BBB crossing and brain accumulation of this nanocarrier are boosted by the rapid glycaemic increase after fasting and by the putative phenomenon of the highly expressed glucose transporter-1 (GLUT1) in brain capillary endothelial cells migrating from the luminal to the abluminal plasma membrane. The precisely controlled glucose density on the surface of the nanocarrier enables the regulation of its distribution within the brain, and thus is successfully optimized to increase the number of nanocarriers accumulating in neurons.There are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid glycaemic increase the accumulation of a glucosylated nanocarrier in the brain can be controlled. Recently, nanocarriers that transport bioactive substances to a target site in the body have attracted considerable attention and undergone rapid progression in terms of the state of the art. However, few nanocarriers can enter the brain via a systemic route through the blood-brain barrier (BBB) to efficiently reach neurons. Here we prepare a self-assembled supramolecular nanocarrier with a surface featuring properly configured glucose. The BBB crossing and brain accumulation of this nanocarrier are boosted by the rapid glycaemic increase after fasting and by the putative phenomenon of the highly expressed glucose transporter-1 (GLUT1) in brain capillary endothelial cells migrating from the luminal to the abluminal plasma membrane. The precisely controlled glucose density on the surface of the nanocarrier enables the regulation of its distribution within the brain, and thus is successfully optimized to increase the number of nanocarriers accumulating in neurons. There are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid glycaemic increase the accumulation of a glucosylated nanocarrier in the brain can be controlled. |
| ArticleNumber | 1001 |
| Author | Osada, K. Anraku, Y. Toh, K. Kataoka, K. Uchida, S. Itaka, K. Nishiyama, N. Mizusawa, H. Mizoguchi, A. Fukusato, Y. Yokota, T. Ishii, T. Nishina, K. Nitta, K. Miyata, K. Kuwahara, H. Yamasoba, T. Matsumoto, Y. |
| Author_xml | – sequence: 1 givenname: Y. surname: Anraku fullname: Anraku, Y. organization: Department of Bioengineering, Graduate School of Engineering, The University of Tokyo – sequence: 2 givenname: H. surname: Kuwahara fullname: Kuwahara, H. organization: Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Center for Brain Integration Research, Tokyo Medical and Dental University (TMDU) – sequence: 3 givenname: Y. surname: Fukusato fullname: Fukusato, Y. organization: Department of Bioengineering, Graduate School of Engineering, The University of Tokyo – sequence: 4 givenname: A. surname: Mizoguchi fullname: Mizoguchi, A. organization: Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo – sequence: 5 givenname: T. surname: Ishii fullname: Ishii, T. organization: Department of Bioengineering, Graduate School of Engineering, The University of Tokyo – sequence: 6 givenname: K. surname: Nitta fullname: Nitta, K. organization: Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Center for Brain Integration Research, Tokyo Medical and Dental University (TMDU) – sequence: 7 givenname: Y. orcidid: 0000-0002-0530-1326 surname: Matsumoto fullname: Matsumoto, Y. organization: Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo – sequence: 8 givenname: K. surname: Toh fullname: Toh, K. organization: Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion – sequence: 9 givenname: K. surname: Miyata fullname: Miyata, K. organization: Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo – sequence: 10 givenname: S. surname: Uchida fullname: Uchida, S. organization: Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo – sequence: 11 givenname: K. surname: Nishina fullname: Nishina, K. organization: Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Center for Brain Integration Research, Tokyo Medical and Dental University (TMDU) – sequence: 12 givenname: K. surname: Osada fullname: Osada, K. organization: Department of Bioengineering, Graduate School of Engineering, The University of Tokyo – sequence: 13 givenname: K. surname: Itaka fullname: Itaka, K. organization: Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo – sequence: 14 givenname: N. surname: Nishiyama fullname: Nishiyama, N. organization: Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology – sequence: 15 givenname: H. surname: Mizusawa fullname: Mizusawa, H. organization: Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Center for Brain Integration Research, Tokyo Medical and Dental University (TMDU) – sequence: 16 givenname: T. surname: Yamasoba fullname: Yamasoba, T. organization: Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo – sequence: 17 givenname: T. surname: Yokota fullname: Yokota, T. email: tak-yokota.nuro@tmd.ac.jp organization: Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Center for Brain Integration Research, Tokyo Medical and Dental University (TMDU) – sequence: 18 givenname: K. surname: Kataoka fullname: Kataoka, K. email: kataoka@bmw.t.u-tokyo.ac.jp organization: Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Policy Alternatives Research Institute, The University of Tokyo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29042554$$D View this record in MEDLINE/PubMed |
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| Snippet | Recently, nanocarriers that transport bioactive substances to a target site in the body have attracted considerable attention and undergone rapid progression... There are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid... |
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| SubjectTerms | 631/378/1341 631/61/350/2093 639/925/352/152 Accumulation Animals Biological activity Blood Glucose - metabolism Blood-brain barrier Blood-Brain Barrier - metabolism Brain - blood supply Brain - metabolism Cell migration Drug Carriers - metabolism Drug Carriers - pharmacokinetics Endothelial cells Female Glucose Glucose - metabolism Glucose transporter Glucose Transporter Type 1 - metabolism Glycosylation Humanities and Social Sciences Humans Mice, Inbred BALB C Micelles Microscopy, Confocal multidisciplinary Nanoparticles - metabolism Neurons Neurons - metabolism Polymers - chemistry Polymers - metabolism Science Science (multidisciplinary) Transport |
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| Title | Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain |
| URI | https://link.springer.com/article/10.1038/s41467-017-00952-3 https://www.ncbi.nlm.nih.gov/pubmed/29042554 https://www.proquest.com/docview/1952162794 https://www.proquest.com/docview/1952529624 https://pubmed.ncbi.nlm.nih.gov/PMC5645389 https://doaj.org/article/0fc143dfc7464c2e803e239b8d4ccb42 |
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