Facilitated antigen presentation and its inhibition by blocking IgG antibodies depends on IgE repertoire complexity

• Published in: Journal of allergy and clinical immunology Vol. 127; no. 4; pp. 1029 - 1037
• Main Authors: Holm, Jens, Willumsen, Nicholas, Würtzen, Peter A., Christensen, Lars H., Lund, Kaare
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.04.2011; Elsevier; Elsevier Limited
• Subjects: allergen; allergens; Allergies; Allergy; Allergy and Immunology; antibodies; Antibodies, Blocking - immunology; Antibody Affinity - immunology; antibody clonality; antibody repertoire; antibody-binding affinity; antigen presentation; Antigen Presentation - immunology; Antigens, Dermatophagoides - immunology; Arthropod Proteins; B-Lymphocytes - immunology; basophils; Biological and medical sciences; blocking IgG; CD4-positive T-lymphocytes; Cell Separation; Early intervention; Experiments; facilitated antigen presentation; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; hypersensitivity; Immune system; Immunoassay; immunoglobulin E; Immunoglobulin E - immunology; immunoglobulin G; Immunoglobulin G - immunology; Immunopathology; inflammation; Lymphocyte Activation - immunology; Lymphocytes; mast cells; Medical sciences; patients; Receptors, IgE - immunology; rIgE; rIgG; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Studies; T cell receptors; T-cell activation; T-Lymphocytes - immunology; Allergy; allergen; rIgE; rIgG; h; antibody-binding affinity; l; m; antibody repertoire; T-cell activation; FAP; blocking IgG; antibody clonality; facilitated antigen presentation; SIT; Low-affinity antibody; Medium-affinity antibody; Specific immunotherapy; High-affinity antibody; Clonality; IgE; IgG; Activation; Blocking antibody; rlgE; rlgG; Immunology; T-Lymphocyte; Immunologic repertoire; Inhibition; anti-body-binding affinity; Immunopathology; Antigen presentation; Immunoglobulins; Blocking; Affinity; Inhibitor; Allergen

The antibody repertoires of allergic subjects are characterized by the presence of allergen-specific IgE antibodies. We have previously shown that the composition of the IgE repertoire is critical for allergen-mediated activation of human effector cells. Activation of CD4 + T cells in allergic subje...