The neural basis of visuospatial perception in Alzheimer's disease and healthy elderly comparison subjects: An fMRI study

• Published in: Psychiatry research. Neuroimaging Vol. 172; no. 2; pp. 109 - 116
• Main Authors: Thiyagesh, Subha N., Farrow, Tom F.D., Parks, Randolph W., Accosta-Mesa, Hector, Young, Claire, Wilkinson, Iain D., Hunter, Michael D., Woodruff, Peter W.R.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 15.05.2009; Elsevier
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer Disease - physiopathology; Biological and medical sciences; Brain - physiopathology; Cognition Disorders - diagnosis; Cognition Disorders - physiopathology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Depth perception; Depth Perception - physiology; Female; Humans; Magnetic Resonance Imaging; Male; Medical sciences; Memory; Motion Perception - physiology; Neurology; Neuropsychological Tests; Normal aging; Organic mental disorders. Neuropsychology; Orientation - physiology; Oxygen - blood; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radiology; Space Perception - physiology; Task Performance and Analysis; Visual Perception - physiology; Depth perception; Magnetic resonance imaging; Normal aging; Memory; Human; Nervous system diseases; Senescence; Healthy subject; Alzheimer disease; Space perception; Nuclear magnetic resonance imaging; Depth; Cerebral disorder; Vision; Central nervous system disease; Medical imagery; Degenerative disease; Elderly; Functional imaging

The neural basis of visuospatial deficits in Alzheimer's disease is unclear. We wished to investigate the neural basis of visuospatial perception in patients with Alzheimer's disease compared with healthy elderly comparison subjects using functional magnetic resonance imaging (fMRI). Twelv...