Certain Forms of Matrix Metalloproteinase-9 Accumulate in the Extracellular Space After Microdialysis Probe Implantation and Middle Cerebral Artery Occlusion/Reperfusion

• Published in: Journal of cerebral blood flow and metabolism Vol. 22; no. 8; pp. 918 - 925
• Main Authors: Planas, Anna M., Justicia, Carles, Solé, Sònia, Friguls, Bibiana, Cervera, Álvaro, Adell, Albert, Chamorro, Ángel
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2002; Lippincott Williams & Wilkins; Sage Publications Ltd
• Subjects: Animals; Biological and medical sciences; Brain - enzymology; Brain - pathology; Brain Ischemia - enzymology; Brain Ischemia - pathology; Extracellular Space - enzymology; Isoenzymes - metabolism; Male; Matrix Metalloproteinase 9 - metabolism; Medical sciences; Microdialysis; Middle Cerebral Artery; Neurology; Neutrophil Infiltration; Peroxidase - metabolism; Rats; Rats, Sprague-Dawley; Reperfusion; Vascular diseases and vascular malformations of the nervous system; Focal ischemia; Brain; Stroke; In vivo microdialysis; Injury; Neutrophils; Immunohistochemistry; Focal lesion; Rat; Cardiovascular disease; Metalloendopeptidases; Vascular disease; Reperfusion; Ischemia; Immunoblotting assay; Cerebrovascular disease; Nervous system diseases; Enzyme; Rodentia; Exploration; Gelatinase B; Cerebral disorder; Pathology; Peptidases; In vivo; Vertebrata; Experimental disease; Mammalia; Microdialysis; Animal; Central nervous system disease; Hydrolases; Brain (vertebrata)

Matrix metalloproteinases (MMPs) are activated in focal cerebral ischemia. The activation of MMP-9 is involved in blood—brain barrier breakdown and tissue remodeling. The MMPs are released to the extracellular space, but the form and fate of secreted enzymes in brain are unknown. Using microdialysis...