Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury

• Published in: Antioxidants Vol. 11; no. 9; p. 1810
• Main Authors: Bondi, Corry D., Rush, Brittney M., Hartman, Hannah L., Wang, Jiaxuan, Al-Bataineh, Mohammad M., Hughey, Rebecca P., Tan, Roderick J.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.09.2022; MDPI
• Subjects: acute kidney injury; Acute renal failure; Antibodies; Creatinine; Fibrosis; HIF-1α; Hypoxia; Hypoxia-inducible factor 1a; Ischemia; Kidney diseases; Kidneys; Laboratory animals; Localization; NRF2; nutrient; Physiological aspects; Proteins; Reagents; Renal function; Reperfusion; reperfusion injury; siRNA; Transcription factors; Vascular endothelial growth factor; United States; United States > US; HIF-1α; acute kidney injury; nutrient; NRF2; ischemia

Acute kidney injury (AKI) is a rapid decline in renal function and can occur after ischemia/reperfusion injury (IRI) to the tubular epithelia. The nuclear factor erythroid-2-related factor 2 (NRF2) pathway protects against AKI and AKI-to-chronic kidney disease (CKD) progression, but we previously de...