Dietary iron restriction alleviates renal tubulointerstitial injury induced by protein overload in mice

• Published in: Scientific reports Vol. 7; no. 1; pp. 10621 - 10
• Main Authors: Ikeda, Yasumasa, Horinouchi, Yuya, Hamano, Hirofumi, Hirayama, Tasuku, Kishi, Seiji, Izawa-Ishizawa, Yuki, Imanishi, Masaki, Zamami, Yoshito, Takechi, Kenshi, Miyamoto, Licht, Ishizawa, Keisuke, Aihara, Ken-ichi, Nagasawa, Hideko, Tsuchiya, Koichiro, Tamaki, Toshiaki
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.09.2017; Nature Publishing Group
• Subjects: 38/77; 64/60; 692/4022/1585/104; 692/4022/1585/2760; 82/51; 82/80; Acute Kidney Injury - diet therapy; Acute Kidney Injury - etiology; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Animal models; Animals; Biomarkers; Bovine serum albumin; Cytokines; Cytokines - metabolism; Dietary restrictions; Disease Models, Animal; Extracellular matrix; Gene expression; Humanities and Social Sciences; Immunohistochemistry; Inflammasomes; Inflammasomes - metabolism; Inflammation; Inflammation Mediators - metabolism; Iron; Iron - metabolism; Iron, Dietary; Kidney Function Tests; Kidneys; Macrophages; Male; Mice; multidisciplinary; NAD(P)H oxidase; NADPH Oxidases - metabolism; Nephritis, Interstitial - diet therapy; Nephritis, Interstitial - etiology; Nephritis, Interstitial - metabolism; Nephritis, Interstitial - pathology; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Overdose; Oxidative Stress; Proteins; Proteinuria; Proteinuria - complications; Proteinuria - metabolism; Pyrin protein; Renal function; Rodents; Science; Science (multidisciplinary); Serum Albumin, Bovine - administration & dosage; Serum Albumin, Bovine - adverse effects; Superoxide

Increased proteinuria causes tubulointerstitial injury due to inflammation in chronic kidney disease (CKD). Iron restriction exhibits protective effects against renal dysfunction; however, its effects against protein overload-induced tubulointerstitial damage remain unclear. Here, we investigated di...