3D printing approaches for cardiac tissue engineering and role of immune modulation in tissue regeneration

Conventional tissue engineering, cell therapy, and current medical approaches were shown to be successful in reducing mortality rate and complications caused by cardiovascular diseases (CVDs). But still they have many limitations to fully manage CVDs due to complex composition of native myocardium a...

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Bibliographic Details
Published inInternational journal of nanomedicine Vol. 14; pp. 1311 - 1333
Main Authors Qasim, Muhammad, Haq, Farhan, Kang, Min-Hee, Kim, Jin-Hoi
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2019
Taylor & Francis Ltd
Dove Medical Press
Subjects
3-D printers
3D printing
Acids
Analysis
Biomedical materials
Bioprinting
Blood & organ donations
Bone marrow
Cardiovascular disease
Cardiovascular diseases
Cardiovascular diseases (CVDs)
Cell adhesion & migration
Cell culture
Chemokines
Congenital diseases
Coronary vessels
Cytokines
Growth factors
Health aspects
Heart attacks
Heart failure
Humans
Immune system
Immunomodulation
Morphology
Physiology
Printing, Three-Dimensional
Regeneration
Regeneration - physiology
Review
Scaffolds
Sibutramine
Stem cells
Thioridazine
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds - chemistry
scaffolds
cardiovascular diseases
regeneration
cell therapy
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Summary:Conventional tissue engineering, cell therapy, and current medical approaches were shown to be successful in reducing mortality rate and complications caused by cardiovascular diseases (CVDs). But still they have many limitations to fully manage CVDs due to complex composition of native myocardium and microvascularization. Fabrication of fully functional construct to replace infarcted area or regeneration of progenitor cells is important to address CVDs burden. Three-dimensional (3D) printed scaffolds and 3D bioprinting technique have potential to develop fully functional heart construct that can integrate with native tissues rapidly. In this review, we presented an overview of 3D printed approaches for cardiac tissue engineering, and advances in 3D bioprinting of cardiac construct and models. We also discussed role of immune modulation to promote tissue regeneration.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S189587