Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia

• Published in: The Journal of physiology Vol. 589; no. 22; pp. 5517 - 5528
• Main Authors: Vanhatalo, Anni, Fulford, Jonathan, Bailey, Stephen J., Blackwell, James R., Winyard, Paul G., Jones, Andrew M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2011; Wiley Subscription Services, Inc; Blackwell Science Inc
• Subjects: Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Exercise Test; Exercise Tolerance - drug effects; Female; Humans; Hypoxia - blood; Hypoxia - drug therapy; Hypoxia - physiopathology; Integrative; Male; Muscle, Skeletal - drug effects; Muscle, Skeletal - physiopathology; Nitrates - pharmacology; Nitrites - blood; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Roots - chemistry; Young Adult

Non‐Technical Summary  Reduced atmospheric O2 availability (hypoxia) impairs muscle oxidative energy production and exercise tolerance. We show that dietary supplementation with inorganic nitrate reduces markers of muscle fatigue and improves high‐intensity exercise tolerance in healthy adults inhal...