NMR structure of a fungal virulence factor reveals structural homology with mammalian saposin B

• Published in: Molecular microbiology Vol. 72; no. 2; pp. 344 - 353
• Main Authors: Beck, Moriah R, DeKoster, Gregory T, Cistola, David P, Goldman, William E
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.04.2009; Blackwell Publishing Ltd; Blackwell
• Subjects: Amino Acid Sequence; Bacterial proteins; Binding sites; Biological and medical sciences; Calcium-Binding Proteins - chemistry; Dimerization; Fundamental and applied biological sciences. Psychology; Fungal Proteins - chemistry; Fungi; Histoplasma - chemistry; Histoplasma capsulatum; Lipids; Microbiology; Models, Molecular; Molecular Sequence Data; NMR; Nuclear magnetic resonance; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Saposins - chemistry; Virology; Virulence Factors - chemistry; Vertebrata; Mammalia; Microbiology; Virulence; Glycoprotein; Homology; NMR spectrometry

The fungal protein CBP ( calcium binding protein) is a known virulence factor with an unknown virulence mechanism. The protein was identified based on its ability to bind calcium and its prevalence as Histoplasma capsulatum's most abundant secreted protein. However, CBP has no sequence homology...