The secondary bile acids, ursodeoxycholic acid and lithocholic acid, protect against intestinal inflammation by inhibition of epithelial apoptosis

• Published in: Physiological reports Vol. 8; no. 12; pp. e14456 - n/a
• Main Authors: Lajczak‐McGinley, Natalia K., Porru, Emanule, Fallon, Ciara M., Smyth, Jessica, Curley, Caitriona, McCarron, Paul A., Tambuwala, Murtaza M., Roda, Aldo, Keely, Stephen J.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2020; John Wiley and Sons Inc; Wiley
• Subjects: Acids; Apoptosis; Bile; bile acid; Bile acids; Caspase; Cecum; Cell culture; Clinical trials; colitis; Cytokines; Dextran; Disease; Drinking water; epithelial barrier function; High-performance liquid chromatography; Inflammation; Inflammatory bowel disease; Intestine; Metabolites; Mucosa; Original Research; Pathogenesis; Permeability; Physiology; Ursodeoxycholic acid; apoptosis; colitis; bile acid; epithelial barrier function

Increased epithelial permeability is a key feature of IBD pathogenesis and it has been proposed that agents which promote barrier function may be of therapeutic benefit. We have previously reported the secondary bile acid, ursodeoxycholic acid (UDCA), to be protective in a mouse model of colonic inf...