Detection of hypermethylated genes as markers for cervical screening in women living with HIV

• Published in: Journal of the International AIDS Society Vol. 21; no. 8; pp. e25165 - n/a
• Main Authors: Kremer, Wieke W, Van Zummeren, Marjolein, Novianti, Putri W, Richter, Karin L, Verlaat, Wina, Snijders, Peter JF, Heideman, Daniëlle AM, Steenbergen, Renske DM, Dreyer, Greta, Meijer, Chris JLM
• Format: Journal Article
• Language: English
• Published: Switzerland International AIDS Society 01.08.2018; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Acquired immune deficiency syndrome; AIDS; Biko, Stephen; Cancer screening; Cellular biology; Cervical cancer; Cervix dysplasia; Complications and side effects; Diagnosis; DNA methylation; DNA Methylation Marker Testing; Early Detection of Cancer; Genes; Genetic aspects; Genetic markers; High‐grade Cervical Intraepithelial Neoplasia; HIV; HIV infections; Human immunodeficiency virus; Human Immuno‐deficiency Virus; Human Papillomavirus; Identification and classification; Infections; Medical screening; Methods; Outpatient care facilities; Population; Risk factors; Scholarships & fellowships; Uterine Cervical Neoplasms; Womens health; South Africa; Netherlands; Uterine Cervical Neoplasms; Human Papillomavirus; High-grade Cervical Intraepithelial Neoplasia; Human Immuno-deficiency Virus; Early Detection of Cancer; DNA Methylation Marker Testing

Introduction To evaluate the performance of hypermethylation analysis of ASCL1, LHX8 and ST6GALNAC5 in physician‐taken cervical scrapes for detection of cervical cancer and cervical intraepithelial neoplasia (CIN) grade 3 in women living with HIV (WLHIV) in South Africa. Methods Samples from a prosp...