In utero exposure to HIV and/or antiretroviral therapy: a systematic review of preclinical and clinical evidence of cognitive outcomes

• Published in: Journal of the International AIDS Society Vol. 22; no. 4; pp. e25275 - n/a
• Main Authors: McHenry, Megan S, Balogun, Kayode A, McDonald, Brenna C, Vreeman, Rachel C, Whipple, Elizabeth C, Serghides, Lena
• Format: Journal Article
• Language: English
• Published: Switzerland International AIDS Society 01.04.2019; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Acquired immune deficiency syndrome; Adolescent; Age; AIDS; Amphetamines; Analysis; Anisotropy; Antiretroviral agents; Antiretroviral drugs; antiretroviral therapy; Brain; Brain - diagnostic imaging; Brain - growth & development; Brain - physiopathology; Care and treatment; Child; Child health; Child, Preschool; Cognition; Cognition - drug effects; Drug therapy; Female; highly active; HIV; HIV infections; HIV Infections - drug therapy; HIV Infections - physiopathology; HIV Infections - transmission; Human immunodeficiency virus; Human subjects; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical - prevention & control; Intelligence; laboratory animal science; Male; maternal exposure; NMR; Nuclear magnetic resonance; Patient outcomes; Pregnancy; Pregnancy Complications, Infectious - drug therapy; Prenatal Exposure Delayed Effects - physiopathology; Prenatal Exposure Delayed Effects - psychology; Review; Reviews; Studies; Systematic review; South Africa; highly active; maternal exposure; HIV; cognition; laboratory animal science; antiretroviral therapy; brain

Introduction With the increasing number of children exposed to HIV or antiretroviral therapy in utero, there are concerns that this population may have worse neurodevelopmental outcomes compared to those who are unexposed. The objective of this study was to systematically review the clinical and pre...