Chronic oral ingestion of l‐carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans

• Published in: The Journal of physiology Vol. 589; no. 4; pp. 963 - 973
• Main Authors: Wall, Benjamin T., Stephens, Francis B., Constantin‐Teodosiu, Dumitru, Marimuthu, Kanagaraj, Macdonald, Ian A., Greenhaff, Paul L.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 15.02.2011; Wiley Subscription Services, Inc; Blackwell Science Inc
• Subjects: Administration, Oral; Adult; Anaerobics; Carnitine - administration & dosage; Carnitine - metabolism; Dietary Carbohydrates - administration & dosage; Double-Blind Method; Energy Metabolism - physiology; Exercise - physiology; Exercise Test - methods; Humans; Male; Muscle, Skeletal - metabolism; Oxygen Consumption - physiology; Skeletal Muscle and Exercise; Sports - physiology; Time Factors; Young Adult

Non‐technical summary After 30 years of endeavour, this is the first study to show that muscle carnitine content can be increased in humans by dietary means and, perhaps more importantly, that carnitine plays a dual role in skeletal muscle fuel metabolism that is exercise intensity dependent. Specif...