Parental asthma and risk of autism spectrum disorder in offspring: A population and family‐based case‐control study

• Published in: Clinical and experimental allergy Vol. 49; no. 6; pp. 883 - 891
• Main Authors: Gong, Tong, Lundholm, Cecilia, Rejnö, Gustaf, Bölte, Sven, Larsson, Henrik, D'Onofrio, Brian M., Lichtenstein, Paul, Almqvist, Catarina
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.06.2019; John Wiley and Sons Inc
• Subjects: Adrenergic beta-2 Receptor Agonists - administration & dosage; Adrenergic beta-2 Receptor Agonists - adverse effects; Adult; Asthma; Asthma - drug therapy; Asthma - epidemiology; Autism; autism spectrum disorder; Autism Spectrum Disorder - chemically induced; Autism Spectrum Disorder - epidemiology; Case-Control Studies; Child; Children; Confidence intervals; confounding; Female; Follow-Up Studies; Humans; Male; Maternal Exposure - adverse effects; medications during pregnancy; Mothers; nested case-control; Original; ORIGINAL ARTICLES; Pregnancy; Prenatal experience; Prenatal exposure; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - epidemiology; Registries; Siblings; Sweden; Sweden; confounding; asthma; autism spectrum disorder; medications during pregnancy; nested case-control

Summary Background Associations between parental asthma and prenatal exposure to asthma medications with offspring autism spectrum disorder (ASD) have been reported. However, the associations might be confounded by unmeasured (genetic and shared environmental) familial factors. Objective We investig...