Boc-L-酪氨酸N／O-选择性甲基化反应

研究了Boc—L-酪氨酸不同位置甲基化衍生物选择性制备方法。Boc-酪氨酸在不同碱存在下与碘甲烷和硫酸二甲酯等不同甲基化试剂反应，合成了Boc—L-酪氨酸甲酯、Boc—L-4-甲氧基苯丙氨酸甲酯和Boc—L-N-甲基-4-甲氧基苯丙氨酸等N／O-甲基化Boc-酪氨酸衍生物。...

Full description

Saved in:
Bibliographic Details
Published in河北科技大学学报 Vol. 35; no. 3; pp. 233 - 236
Main Author 相晨爽 张晓芳 黄净 杨毅华 刘守信
Format Journal Article
LanguageChinese
Published 河北科技大学化学与制药工程学院,河北石家庄,050018 2014
Subjects
Boc—L一酪氨酸
N一甲基化
选择性
醚化
selectivity
N-methylation
etherification
Boc-L-tyrosine
N-甲基化
醚化
选择性
Boc-L-酪氨酸
Online AccessGet full text

Cover

More Information
Summary:研究了Boc—L-酪氨酸不同位置甲基化衍生物选择性制备方法。Boc-酪氨酸在不同碱存在下与碘甲烷和硫酸二甲酯等不同甲基化试剂反应，合成了Boc—L-酪氨酸甲酯、Boc—L-4-甲氧基苯丙氨酸甲酯和Boc—L-N-甲基-4-甲氧基苯丙氨酸等N／O-甲基化Boc-酪氨酸衍生物。
Bibliography:XIANG Chenshuang, ZHANG Xiaofang, HUANG Jing, YANG Yihua, LIU Shouxin （School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang Hebei 050018, China）
At different locations of Boc-L-tyrosine, the selective preparation method of methylation ramifications is studied. Selective methylation reactions of Boc-L-tyrosine and methyl iodide or dimethyl sulphate with the existence of different alkalis are carried out, and N/O-methylation Boc-tyrosine ramifications such as Boc-L-tyrosine methyl ester, Boc-4-methoxyl-L-phenylalanine methyl ester and Boc-N-methyl-4-methoxy-L-phenylalanine are easily prepared.
Boc-L-tyrosine; selectivity; N-methylation; etherification
13-1225/TS
ISSN:1008-1542
DOI:10.7535/hbkd.2014yx03004