A cross-dehydrogenative C(sp3)−H heteroarylation via photo-induced catalytic chlorine radical generation

• Published in: Nature communications Vol. 12; no. 1; pp. 4010 - 9
• Main Authors: Huang, Chia-Yu, Li, Jianbin, Li, Chao-Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.06.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/549/933; 639/638/77/888; Alkanes; Alkylation; Catalysts; Chemistry; Chlorides; Chlorine; Cobalt; Couplings; Dehydrogenation; Design; Humanities and Social Sciences; Hydrogen; Hydrogen bonds; Hydrogen evolution; Ligands; multidisciplinary; Oxidants; Oxidation; Oxidizing agents; Radicals; Science; Science (multidisciplinary); Solvents; Substrates

Hydrogen atom abstraction (HAT) from C( sp 3 )–H bonds of naturally abundant alkanes for alkyl radical generation represents a promising yet underexplored strategy in the alkylation reaction designs since involving stoichiometric oxidants, excessive alkane loading, and limited scope are common drawb...