CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain

• Published in: Blood Vol. 107; no. 1; pp. 309 - 316
• Main Authors: Courret, Nathalie, Darche, Sylvie, Sonigo, Pierre, Milon, Geneviève, Buzoni-Gâtel, Dominique, Tardieux, Isabelle
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.01.2006; The Americain Society of Hematology; American Society of Hematology; 2006 by The American Society of Hematology
• Subjects: Animals; Biological and medical sciences; Brain - parasitology; CD11b Antigen; CD11c Antigen; Dendritic Cells - parasitology; Green Fluorescent Proteins - analysis; Green Fluorescent Proteins - genetics; Human protozoal diseases; Immunophenotyping; Infectious diseases; Intestine, Small - parasitology; Leukocytes - immunology; Leukocytes - parasitology; Life Sciences; Lymph Nodes - pathology; Medical sciences; Mice; Mice, Inbred Strains; Mice, Transgenic; Parasitic diseases; Phagocytes; Protozoal diseases; Toxoplasma - physiology; Toxoplasmosis; Toxoplasmosis - parasitology; Protozoa; Apicomplexa; Protozoal disease; Monocyte; Leukocyte; Rodentia; Central nervous system; Parasitosis; Invasion; Encephalon; Infection; Vertebrata; Mammalia; Toxoplasma gondii; Mouse; Toxoplasmosis; Animal; Transport

The protozoan parasite Toxoplasma gondii enters hosts through the intestinal mucosa and colonizes distant tissues such as the brain, where its progeny persists for a lifetime. We investigated the role of CD11c- and CD11b-expressing leukocytes in T gondii transport during the early step of parasitism...