Nicotine is a risk factor for dental caries: An in vivo study

Streptococcus mutans is an important pathogen in the development of dental caries. Many studies have focused on the relationship between nicotine and S. mutans in vitro. The aim of this study was to investigate the effect of nicotine on the growth of S. mutans and its cariogenic potential in vivo. S...

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Published inJournal of dental sciences Vol. 13; no. 1; pp. 30 - 36
Main Authors Liu, Shiyu, Wu, Tianmu, Zhou, Xuedong, Zhang, Bo, Huo, Sibei, Yang, Yutao, Zhang, Keke, Cheng, Lei, Xu, Xin, Li, Mingyun
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2018
Association for Dental Sciences of the Republic of China
Elsevier
Subjects
Dental caries
Nicotine
Original
Rats
Streptococcus mutans
Rats
Dental caries
Streptococcus mutans
Nicotine
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Abstract Streptococcus mutans is an important pathogen in the development of dental caries. Many studies have focused on the relationship between nicotine and S. mutans in vitro. The aim of this study was to investigate the effect of nicotine on the growth of S. mutans and its cariogenic potential in vivo. Sixteen male Specific-pathogen-free Wistar rats were divided into 2 groups (nicotine-treated and nicotine-untreated group) and infected with S. mutans. The S. mutans suspension was treated with 1 mg/mL nicotine in the nicotine-treated group. The Keyes method was used to evaluate sulcal caries of rats, and dental plaque on molar teeth was observed by scanning electron microscopy (SEM). Incidence of sulcal caries was higher in nicotine-treated group compared to nicotine-untreated group (42.7 ± 1.7 vs 37.3 ± 4.9, P = 0.009). Severity of caries increased with nicotine treatment. The slightly dentinal caries scores and moderate dentinal caries scores were higher in the presence of nicotine (P < 0.001). Increased number of S. mutans cells attached to dental surface was observed under SEM in the nicotine-treated group. Nicotine would promote the attachment of S. mutans to dental surface, and further increase the incidence and severity of dental caries. Therefore, nicotine might be a risk factor for smoking-induced caries.
AbstractList Streptococcus mutans is an important pathogen in the development of dental caries. Many studies have focused on the relationship between nicotine and S. mutans in vitro. The aim of this study was to investigate the effect of nicotine on the growth of S. mutans and its cariogenic potential in vivo. Sixteen male Specific-pathogen-free Wistar rats were divided into 2 groups (nicotine-treated and nicotine-untreated group) and infected with S. mutans. The S. mutans suspension was treated with 1 mg/mL nicotine in the nicotine-treated group. The Keyes method was used to evaluate sulcal caries of rats, and dental plaque on molar teeth was observed by scanning electron microscopy (SEM). Incidence of sulcal caries was higher in nicotine-treated group compared to nicotine-untreated group (42.7 ± 1.7 vs 37.3 ± 4.9, P = 0.009). Severity of caries increased with nicotine treatment. The slightly dentinal caries scores and moderate dentinal caries scores were higher in the presence of nicotine (P < 0.001). Increased number of S. mutans cells attached to dental surface was observed under SEM in the nicotine-treated group. Nicotine would promote the attachment of S. mutans to dental surface, and further increase the incidence and severity of dental caries. Therefore, nicotine might be a risk factor for smoking-induced caries.
Background/purpose: Streptococcus mutans is an important pathogen in the development of dental caries. Many studies have focused on the relationship between nicotine and S. mutans in vitro. The aim of this study was to investigate the effect of nicotine on the growth of S. mutans and its cariogenic potential in vivo. Materials and methods: Sixteen male Specific-pathogen-free Wistar rats were divided into 2 groups (nicotine-treated and nicotine-untreated group) and infected with S. mutans. The S. mutans suspension was treated with 1 mg/mL nicotine in the nicotine-treated group. The Keyes method was used to evaluate sulcal caries of rats, and dental plaque on molar teeth was observed by scanning electron microscopy (SEM). Results: Incidence of sulcal caries was higher in nicotine-treated group compared to nicotine-untreated group (42.7 ± 1.7 vs 37.3 ± 4.9, P = 0.009). Severity of caries increased with nicotine treatment. The slightly dentinal caries scores and moderate dentinal caries scores were higher in the presence of nicotine (P < 0.001). Increased number of S. mutans cells attached to dental surface was observed under SEM in the nicotine-treated group. Conclusion: Nicotine would promote the attachment of S. mutans to dental surface, and further increase the incidence and severity of dental caries. Therefore, nicotine might be a risk factor for smoking-induced caries. Keywords: Dental caries, Streptococcus mutans, Nicotine, Rats
is an important pathogen in the development of dental caries. Many studies have focused on the relationship between nicotine and . The aim of this study was to investigate the effect of nicotine on the growth of and its cariogenic potential . Sixteen male Specific-pathogen-free Wistar rats were divided into 2 groups (nicotine-treated and nicotine-untreated group) and infected with . The suspension was treated with 1 mg/mL nicotine in the nicotine-treated group. The Keyes method was used to evaluate sulcal caries of rats, and dental plaque on molar teeth was observed by scanning electron microscopy (SEM). Incidence of sulcal caries was higher in nicotine-treated group compared to nicotine-untreated group (42.7 ± 1.7 vs 37.3 ± 4.9, P = 0.009). Severity of caries increased with nicotine treatment. The slightly dentinal caries scores and moderate dentinal caries scores were higher in the presence of nicotine (P < 0.001). Increased number of cells attached to dental surface was observed under SEM in the nicotine-treated group. Nicotine would promote the attachment of to dental surface, and further increase the incidence and severity of dental caries. Therefore, nicotine might be a risk factor for smoking-induced caries.
Author Yang, Yutao
Li, Mingyun
Zhang, Bo
Huo, Sibei
Cheng, Lei
Xu, Xin
Liu, Shiyu
Zhou, Xuedong
Zhang, Keke
Wu, Tianmu
AuthorAffiliation b Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China
a State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China
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Issue 1
Keywords Rats
Dental caries
Streptococcus mutans
Nicotine
Language English
License This is an open access article under the CC BY-NC-ND license.
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Snippet Streptococcus mutans is an important pathogen in the development of dental caries. Many studies have focused on the relationship between nicotine and S. mutans...
is an important pathogen in the development of dental caries. Many studies have focused on the relationship between nicotine and . The aim of this study was to...
Background/purpose: Streptococcus mutans is an important pathogen in the development of dental caries. Many studies have focused on the relationship between...
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StartPage 30
SubjectTerms Dental caries
Nicotine
Original
Rats
Streptococcus mutans
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Title Nicotine is a risk factor for dental caries: An in vivo study
URI https://dx.doi.org/10.1016/j.jds.2017.09.006
https://www.ncbi.nlm.nih.gov/pubmed/30895091
https://pubmed.ncbi.nlm.nih.gov/PMC6388820
https://doaj.org/article/5c5087e8d25e4603beab4c6aeed28489
Volume 13
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