Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial
•8IU intranasal oxytocin (OT) treatment dampens amygdala activation in response to emotional faces.•Intravenous OT treatment did not produce these effects, despite comparable blood concentrations.•Nose-to-brain delivery, or at least activity, may have occurred via olfactory and trigeminal nerve path...
Saved in:
| Published in | Psychoneuroendocrinology Vol. 69; pp. 180 - 188 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.07.2016
Pergamon Press |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | •8IU intranasal oxytocin (OT) treatment dampens amygdala activation in response to emotional faces.•Intravenous OT treatment did not produce these effects, despite comparable blood concentrations.•Nose-to-brain delivery, or at least activity, may have occurred via olfactory and trigeminal nerve pathways.
It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social behavior and cognition and what is the optimal dose for OT response. To better understand the delivery routes of intranasal OT administration to the brain and the dose-response, we compared amygdala response to facial stimuli by means of functional magnetic resonance imaging (fMRI) in four treatment conditions, including two different doses of intranasal OT using a novel Breath Powered device, intravenous (IV) OT, which provided similar concentrations of blood plasma OT, and placebo. We adopted a randomized, double-blind, double-dummy, crossover design, with 16 healthy male adults administering a single-dose of these four treatments. We observed a treatment effect on right amygdala activation during the processing of angry and happy face stimuli, with pairwise comparisons revealing reduced activation after the 8IU low dose intranasal treatment compared to placebo. These data suggest the dampening of amygdala activity in response to emotional stimuli occurs via direct intranasal delivery pathways rather than across the blood-brain barrier via systemically circulating OT.
Trial registration: This trial is registered at the U.S. National Institutes of Health clinical trial registry (www.clinicaltrials.gov; NCT01983514) and as EudraCT no. 2013-001608-12. |
|---|---|
| AbstractList | •8IU intranasal oxytocin (OT) treatment dampens amygdala activation in response to emotional faces.•Intravenous OT treatment did not produce these effects, despite comparable blood concentrations.•Nose-to-brain delivery, or at least activity, may have occurred via olfactory and trigeminal nerve pathways.
It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social behavior and cognition and what is the optimal dose for OT response. To better understand the delivery routes of intranasal OT administration to the brain and the dose-response, we compared amygdala response to facial stimuli by means of functional magnetic resonance imaging (fMRI) in four treatment conditions, including two different doses of intranasal OT using a novel Breath Powered device, intravenous (IV) OT, which provided similar concentrations of blood plasma OT, and placebo. We adopted a randomized, double-blind, double-dummy, crossover design, with 16 healthy male adults administering a single-dose of these four treatments. We observed a treatment effect on right amygdala activation during the processing of angry and happy face stimuli, with pairwise comparisons revealing reduced activation after the 8IU low dose intranasal treatment compared to placebo. These data suggest the dampening of amygdala activity in response to emotional stimuli occurs via direct intranasal delivery pathways rather than across the blood-brain barrier via systemically circulating OT.
Trial registration: This trial is registered at the U.S. National Institutes of Health clinical trial registry (www.clinicaltrials.gov; NCT01983514) and as EudraCT no. 2013-001608-12. Highlights • 8IU intranasal oxytocin (OT) treatment dampens amygdala activation in response to emotional faces. • Intravenous OT treatment did not produce these effects, despite comparable blood concentrations. • Nose-to-brain delivery, or at least activity, may have occurred via olfactory and trigeminal nerve pathways It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social behavior and cognition and what is the optimal dose for OT response. To better understand the delivery routes of intranasal OT administration to the brain and the dose-response, we compared amygdala response to facial stimuli by means of functional magnetic resonance imaging (fMRI) in four treatment conditions, including two different doses of intranasal OT using a novel Breath Powered device, intravenous (IV) OT, which provided similar concentrations of blood plasma OT, and placebo. We adopted a randomized, double-blind, double-dummy, crossover design, with 16 healthy male adults administering a single-dose of these four treatments. We observed a treatment effect on right amygdala activation during the processing of angry and happy face stimuli, with pairwise comparisons revealing reduced activation after the 8IU low dose intranasal treatment compared to placebo. These data suggest the dampening of amygdala activity in response to emotional stimuli occurs via direct intranasal delivery pathways rather than across the blood-brain barrier via systemically circulating OT. This trial is registered at the U.S. National Institutes of Health clinical trial registry (www.clinicaltrials.gov; NCT01983514) and as EudraCT no. 2013-001608-12. It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social behavior and cognition and what is the optimal dose for OT response. To better understand the delivery routes of intranasal OT administration to the brain and the dose-response, we compared amygdala response to facial stimuli by means of functional magnetic resonance imaging (fMRI) in four treatment conditions, including two different doses of intranasal OT using a novel Breath Powered device, intravenous (IV) OT, which provided similar concentrations of blood plasma OT, and placebo. We adopted a randomized, double-blind, double-dummy, crossover design, with 16 healthy male adults administering a single-dose of these four treatments. We observed a treatment effect on right amygdala activation during the processing of angry and happy face stimuli, with pairwise comparisons revealing reduced activation after the 8IU low dose intranasal treatment compared to placebo. These data suggest the dampening of amygdala activity in response to emotional stimuli occurs via direct intranasal delivery pathways rather than across the blood-brain barrier via systemically circulating OT. It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social behavior and cognition and what is the optimal dose for OT response. To better understand the delivery routes of intranasal OT administration to the brain and the dose-response, we compared amygdala response to facial stimuli by means of functional magnetic resonance imaging (fMRI) in four treatment conditions, including two different doses of intranasal OT using a novel Breath Powered device, intravenous (IV) OT, which provided similar concentrations of blood plasma OT, and placebo. We adopted a randomized, double-blind, double-dummy, crossover design, with 16 healthy male adults administering a single-dose of these four treatments. We observed a treatment effect on right amygdala activation during the processing of angry and happy face stimuli, with pairwise comparisons revealing reduced activation after the 8IU low dose intranasal treatment compared to placebo. These data suggest the dampening of amygdala activity in response to emotional stimuli occurs via direct intranasal delivery pathways rather than across the blood-brain barrier via systemically circulating OT.UNLABELLEDIt is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social behavior and cognition and what is the optimal dose for OT response. To better understand the delivery routes of intranasal OT administration to the brain and the dose-response, we compared amygdala response to facial stimuli by means of functional magnetic resonance imaging (fMRI) in four treatment conditions, including two different doses of intranasal OT using a novel Breath Powered device, intravenous (IV) OT, which provided similar concentrations of blood plasma OT, and placebo. We adopted a randomized, double-blind, double-dummy, crossover design, with 16 healthy male adults administering a single-dose of these four treatments. We observed a treatment effect on right amygdala activation during the processing of angry and happy face stimuli, with pairwise comparisons revealing reduced activation after the 8IU low dose intranasal treatment compared to placebo. These data suggest the dampening of amygdala activity in response to emotional stimuli occurs via direct intranasal delivery pathways rather than across the blood-brain barrier via systemically circulating OT.This trial is registered at the U.S. National Institutes of Health clinical trial registry (www.clinicaltrials.gov; NCT01983514) and as EudraCT no. 2013-001608-12.TRIAL REGISTRATIONThis trial is registered at the U.S. National Institutes of Health clinical trial registry (www.clinicaltrials.gov; NCT01983514) and as EudraCT no. 2013-001608-12. It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social behavior and cognition and what is the optimal dose for OT response. To better understand the delivery routes of intranasal OT administration to the brain and the dose-response, we compared amygdala response to facial stimuli by means of functional magnetic resonance imaging (fMRI) in four treatment conditions, including two different doses of intranasal OT using a novel Breath Powered device, intravenous (IV) OT, which provided similar concentrations of blood plasma OT, and placebo. We adopted a randomized, double-blind, double-dummy, crossover design, with 16 healthy male adults administering a single-dose of these four treatments. We observed a treatment effect on right amygdala activation during the processing of angry and happy face stimuli, with pairwise comparisons revealing reduced activation after the 8IU low dose intranasal treatment compared to placebo. These data suggest the dampening of amygdala activity in response to emotional stimuli occurs via direct intranasal delivery pathways rather than across the blood-brain barrier via systemically circulating OT. Trial registration: This trial is registered at the U.S. National Institutes of Health clinical trial registry (www.clinicaltrials.gov; NCT01983514) and as EudraCT no. 2013-001608-12. |
| Author | Mahmoud, Ramy A. Smerud, Knut T. Quintana, Daniel S. Rustan, Øyvind G. Djupesland, Per G. Andreassen, Ole A. Westlye, Lars T. Kaufmann, Tobias Alnæs, Dag |
| Author_xml | – sequence: 1 givenname: Daniel S. surname: Quintana fullname: Quintana, Daniel S. organization: NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, University of Oslo, Oslo, Norway – sequence: 2 givenname: Lars T. surname: Westlye fullname: Westlye, Lars T. organization: NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, University of Oslo, Oslo, Norway – sequence: 3 givenname: Dag surname: Alnæs fullname: Alnæs, Dag organization: NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, University of Oslo, Oslo, Norway – sequence: 4 givenname: Øyvind G. surname: Rustan fullname: Rustan, Øyvind G. organization: NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, University of Oslo, Oslo, Norway – sequence: 5 givenname: Tobias surname: Kaufmann fullname: Kaufmann, Tobias organization: NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, University of Oslo, Oslo, Norway – sequence: 6 givenname: Knut T. surname: Smerud fullname: Smerud, Knut T. organization: Smerud Medical Research International AS, Oslo, Norway – sequence: 7 givenname: Ramy A. surname: Mahmoud fullname: Mahmoud, Ramy A. organization: OptiNose US Inc, Yardley, PA, USA – sequence: 8 givenname: Per G. surname: Djupesland fullname: Djupesland, Per G. organization: OptiNose AS, Oslo, Norway – sequence: 9 givenname: Ole A. surname: Andreassen fullname: Andreassen, Ole A. email: o.a.andreassen@medisin.uio.no organization: NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, University of Oslo, Oslo, Norway |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27107209$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNUsuO0zAUjdAgpjPwC4OXbFL8aBIHITTDiMdIRSAea8uxbxgXxw520lK-jw_DoS2LWVBWV7bPPef43nOWnTjvIMsuCJ4TTMqnq3kftw5GcHOaznO8mGOC72UzwiuWM1bik2yGGS7zRcHwaXYW4wpjXPKSPshOaUVwRXE9y34t_QZpHwEZNwTpZJQW-R_bwSvjkAZr1hBAo40ZbtHLADKVD37z507D2ihAWnY9uIhkt_2qpZUoQOy9S5SDR9D5wXiXSONgutGaZ-gK9RBMfwsh3ULbghpy5ZO6t3avZFwex2aVXiJKprTvzM9JMPnM_7K37z7eoCEYaR9m91tpIzza1_Psy-tXn6_f5sv3b26ur5a5KjgbcqCk5FWLiwWnDZOaFFDJlvKmoLqpS6gY47ymTVOwom1ozSsoAQpek7Ip-IKy8-zxjlcFk77jhPNBCoJ5QUXBKKkT4skO0Qf_fYQ4iM5EBdZKB36MgnDMS4ZJxY9Dq5pUC1LjSfdiDx2bDrTog-lk2IrDGhPg-cGYjzFAK5QZ5DT4tFNjk0UxpUasxCE1YkqNwAuRUpPayzvtB4WjjZe7RkhTXxsIIioDToE2IS1PaG-OU7y4Q6GscUZJ-w22EFd-DCk9aRwiUoHFpynTU6TJNEaMq38T_I-D3ymoDdk |
| CitedBy_id | crossref_primary_10_1016_j_psyneuen_2019_104483 crossref_primary_10_1016_j_neubiorev_2017_04_017 crossref_primary_10_1016_j_neuroimage_2018_08_004 crossref_primary_10_1016_j_yhbeh_2020_104822 crossref_primary_10_1016_j_ijpsycho_2021_12_003 crossref_primary_10_1016_j_bpsc_2024_05_010 crossref_primary_10_1016_j_psyneuen_2021_105268 crossref_primary_10_1093_ijnp_pyac059 crossref_primary_10_3390_ijms23010150 crossref_primary_10_4155_tde_2018_0005 crossref_primary_10_1098_rstb_2021_0056 crossref_primary_10_1016_j_bpsc_2021_04_009 crossref_primary_10_4155_tde_2018_0002 crossref_primary_10_1038_tp_2017_103 crossref_primary_10_1016_j_psyneuen_2018_05_031 crossref_primary_10_1038_s41398_020_00890_7 crossref_primary_10_1016_j_bpsgos_2024_100395 crossref_primary_10_1002_ajp_22740 crossref_primary_10_1016_j_jddst_2024_105370 crossref_primary_10_1016_j_nbas_2021_100023 crossref_primary_10_1016_j_biopsycho_2021_108164 crossref_primary_10_1007_s00213_019_05423_9 crossref_primary_10_1016_j_psychres_2024_115893 crossref_primary_10_1177_13623613221137230 crossref_primary_10_1177_10738584241268754 crossref_primary_10_1080_20008198_2017_1302652 crossref_primary_10_1016_j_neuroimage_2018_09_067 crossref_primary_10_1007_s00441_018_2889_8 crossref_primary_10_1080_10837450_2021_1950186 crossref_primary_10_1017_S0033291720003803 crossref_primary_10_1016_j_psyneuen_2023_106666 crossref_primary_10_1016_j_psyneuen_2019_05_022 crossref_primary_10_1038_s41598_021_94407_x crossref_primary_10_1016_j_pneurobio_2022_102239 crossref_primary_10_3390_pharmaceutics14020323 crossref_primary_10_3390_pharmaceutics13071088 crossref_primary_10_1136_bmjopen_2024_090167 crossref_primary_10_1007_s00213_020_05493_0 crossref_primary_10_1038_s42003_020_01610_z crossref_primary_10_1016_j_parkreldis_2022_05_003 crossref_primary_10_1038_s41562_020_0878_x crossref_primary_10_30773_pi_2018_02_19 crossref_primary_10_4236_ojemd_2018_83010 crossref_primary_10_3389_fpsyt_2023_1244027 crossref_primary_10_1002_ajp_22915 crossref_primary_10_1016_j_peptides_2024_171211 crossref_primary_10_3389_fnins_2020_589878 crossref_primary_10_1016_j_biopsych_2017_04_015 crossref_primary_10_1016_j_yhbeh_2017_06_011 crossref_primary_10_3923_ijp_2023_178_184 crossref_primary_10_3389_fnins_2018_00512 crossref_primary_10_1016_j_psyneuen_2021_105642 crossref_primary_10_1038_s41467_020_14845_5 crossref_primary_10_22159_ijap_2024v16i4_50626 crossref_primary_10_3389_fpsyt_2024_1419574 crossref_primary_10_1016_j_biopsycho_2020_107976 crossref_primary_10_1016_j_jconrel_2018_12_036 crossref_primary_10_1016_j_neuroimage_2018_02_035 crossref_primary_10_1038_s41380_020_00864_7 crossref_primary_10_1016_j_psyneuen_2019_104419 crossref_primary_10_1007_s11920_017_0819_1 crossref_primary_10_1016_j_yfrne_2016_12_004 crossref_primary_10_1038_s41386_018_0241_3 crossref_primary_10_1038_s41562_020_00996_4 crossref_primary_10_1016_j_neubiorev_2017_05_007 crossref_primary_10_20900_jpbs_20230008 crossref_primary_10_1038_s41380_023_02075_2 crossref_primary_10_1002_hbm_26498 crossref_primary_10_3389_fendo_2018_00572 crossref_primary_10_1016_j_schres_2019_07_039 crossref_primary_10_1038_s41380_024_02406_x crossref_primary_10_2174_0929867329666220727120646 crossref_primary_10_1038_s41380_025_02898_1 crossref_primary_10_3389_fphar_2021_652473 crossref_primary_10_1016_j_bmc_2017_11_001 crossref_primary_10_1177_2470547016687996 crossref_primary_10_1016_j_pscychresns_2017_11_017 crossref_primary_10_1016_j_jpain_2019_08_010 crossref_primary_10_1016_j_neubiorev_2019_10_012 crossref_primary_10_1038_s41398_021_01241_w crossref_primary_10_1080_17446651_2023_2216794 crossref_primary_10_1017_neu_2016_67 |
| Cites_doi | 10.1038/sj.npp.1300021 10.1523/JNEUROSCI.3984-05.2005 10.1016/j.tins.2012.08.004 10.1038/mp.2015.166 10.1016/j.biopsych.2007.03.025 10.1016/j.neubiorev.2014.12.011 10.1016/S0896-6273(02)00569-X 10.1016/j.psyneuen.2014.03.023 10.1016/S0306-4530(01)00018-X 10.1093/scan/nss062 10.1211/jpp.58.10.0003 10.1111/head.12167 10.1038/tp.2015.93 10.1023/A:1007963824710 10.1016/j.tics.2007.08.016 10.1016/S0924-9338(97)83296-8 10.1038/npp.2015.278 10.1152/physrev.2001.81.2.629 10.1038/npp.2010.123 10.3758/s13423-012-0295-x 10.1073/pnas.89.13.5981 10.1016/j.biopsych.2015.05.003 10.1111/pcn.12364 10.1016/0143-4179(95)90029-2 10.1016/j.biopsych.2015.06.021 10.1016/j.schres.2015.06.005 10.1016/j.psyneuen.2013.11.018 10.1006/nimg.2001.0931 10.1016/j.psyneuen.2012.10.011 10.1016/j.schres.2013.04.023 10.1016/j.neuroimage.2004.07.051 10.1016/j.biopsych.2015.02.002 10.1016/j.neuron.2011.11.030 10.1016/j.neuroscience.2008.07.066 10.4155/tde.14.41 10.1016/j.biopsych.2006.05.030 10.1016/S0140-6736(96)91325-2 10.1038/nrn3044 10.1007/s13346-012-0108-9 10.1111/head.12583 10.1016/j.biopsych.2015.06.028 10.1177/0963721411417547 10.1016/j.psyneuen.2010.01.009 10.1016/j.neuroimage.2009.06.060 10.1007/s00213-013-3062-4 10.1023/A:1025048802629 10.1016/j.psyneuen.2012.11.019 10.1111/j.2517-6161.1995.tb02031.x 10.1016/j.biopsych.2009.09.020 10.1016/j.psyneuen.2013.03.003 10.1111/j.1365-3083.2006.01730.x 10.1016/j.psyneuen.2012.01.011 10.1016/j.psyneuen.2012.07.013 10.1038/npp.2014.183 10.1007/BF02253591 10.1523/JNEUROSCI.5587-06.2007 10.1016/j.psyneuen.2014.02.011 10.1016/j.yhbeh.2012.01.002 10.1038/nature09868 10.1111/jne.12384 10.1016/j.psyneuen.2011.07.020 10.1016/j.psyneuen.2009.06.016 10.1016/j.neuroscience.2004.05.029 10.1006/nimg.2002.1132 10.1523/JNEUROSCI.4572-07.2008 10.1016/S1054-3589(04)50014-5 10.1212/01.WNL.0000067993.60735.77 |
| ContentType | Journal Article |
| Copyright | 2016 The Authors Copyright © 2016 Elsevier Ltd. All rights reserved. info:eu-repo/semantics/openAccess |
| Copyright_xml | – notice: 2016 The Authors – notice: Copyright © 2016 Elsevier Ltd. All rights reserved. – notice: info:eu-repo/semantics/openAccess |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7TK 3HK |
| DOI | 10.1016/j.psyneuen.2016.04.010 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Neurosciences Abstracts NORA - Norwegian Open Research Archives |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Neurosciences Abstracts |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Neurosciences Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1873-3360 |
| EndPage | 188 |
| ExternalDocumentID | 10852_53219 27107209 10_1016_j_psyneuen_2016_04_010 S0306453016301007 1_s2_0_S0306453016301007 |
| Genre | Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 29P 4.4 41~ 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM 9JO AABNK AADFP AAEDT AAEDW AAGJA AAGUQ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXLA AAXUO AAYWO ABBQC ABCQJ ABFNM ABGSF ABIVO ABJNI ABMAC ABMZM ABOYX ABUDA ABWVN ABXDB ACDAQ ACGFS ACIEU ACIUM ACRLP ACRPL ACVFH ACXNI ADBBV ADCNI ADEZE ADMUD ADNMO ADUVX ADVLN AEBSH AEHWI AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGRDE AGUBO AGWIK AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEG HMK HMO HMQ HVGLF HZ~ IHE J1W KOM L7B M29 M2V M39 M41 MO0 MOBAO N9A O-L O9- OAUVE OH0 OKEIE OU- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SNS SPCBC SSB SSH SSN SSU SSY SSZ T5K UAP WUQ XPP YYP Z5R ZGI ZXP ~02 ~G- AACTN AFCTW AFKWA AJOXV AMFUW RIG 6I. AADPK AAFTH AAIAV ABLVK ABYKQ AFYLN AJBFU DOVZS EFLBG LCYCR AAYXX AGRNS CITATION CGR CUY CVF ECM EIF NPM 7X8 7TK 08R 3HK AALMO ABPIF ABPTK |
| ID | FETCH-LOGICAL-c583t-e21687f05482b3ad15e7af28b52db96e7338892bb535fb2987e6ee58916b58423 |
| IEDL.DBID | .~1 |
| ISSN | 0306-4530 1873-3360 |
| IngestDate | Sat Apr 29 05:44:04 EDT 2023 Thu Jul 10 20:35:36 EDT 2025 Thu Jul 10 22:47:06 EDT 2025 Mon Jul 21 05:51:10 EDT 2025 Thu Apr 24 23:07:38 EDT 2025 Tue Jul 01 04:18:27 EDT 2025 Fri Feb 23 02:17:22 EST 2024 Tue Feb 25 19:57:47 EST 2025 Tue Aug 26 18:21:54 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | fMRI Dose-response Oxytocin Intranasal Intravenous dose-response oxytocin intranasal intravenous |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2016 Elsevier Ltd. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c583t-e21687f05482b3ad15e7af28b52db96e7338892bb535fb2987e6ee58916b58423 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 ObjectType-Article-1 ObjectType-Feature-2 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0306453016301007 |
| PMID | 27107209 |
| PQID | 1791741902 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | cristin_nora_10852_53219 proquest_miscellaneous_1808630178 proquest_miscellaneous_1791741902 pubmed_primary_27107209 crossref_citationtrail_10_1016_j_psyneuen_2016_04_010 crossref_primary_10_1016_j_psyneuen_2016_04_010 elsevier_sciencedirect_doi_10_1016_j_psyneuen_2016_04_010 elsevier_clinicalkeyesjournals_1_s2_0_S0306453016301007 elsevier_clinicalkey_doi_10_1016_j_psyneuen_2016_04_010 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2016-07-01 |
| PublicationDateYYYYMMDD | 2016-07-01 |
| PublicationDate_xml | – month: 07 year: 2016 text: 2016-07-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Psychoneuroendocrinology |
| PublicationTitleAlternate | Psychoneuroendocrinology |
| PublicationYear | 2016 |
| Publisher | Elsevier Ltd Pergamon Press |
| Publisher_xml | – name: Elsevier Ltd – name: Pergamon Press |
| References | Wechsler (bib0330) 1999 Merkus, Guchelaar, Bosch, Merkus (bib0235) 2003; 60 Benelli, Bertolini, Poggioli, Menozzi, Basaglia, Arletti (bib0015) 1995; 28 Petrovic, Kalisch, Singer, Dolan (bib0270) 2008; 28 Leknes, Wessberg, Ellingsen, Chelnokova, Olausson, Laeng (bib0200) 2012; 8 Gimpl, Fahrenholz (bib0080) 2001; 81 Guastella, Einfeld, Gray, Rinehart, Tonge, Lambert, Hickie (bib0105) 2010; 67 Djupesland (bib0050) 2012; 3 Yamasue (bib0350) 2016; 70 Leng, Ludwig (bib0205) 2016; 79 Modi, Connor-Stroud, Landgraf, Young, Parr (bib0245) 2014; 45 Hollander, Bartz, Chaplin, Phillips, Sumner, Soorya, Anagnostou, Wasserman (bib0130) 2007; 61 Lischke, Gamer, Berger, Grossmann, Hauenstein, Heinrichs, Herpertz, Domes (bib0210) 2012; 37 Fischl, Salat, Busa, Albert, Dieterich, Haselgrove, Van Der Kouwe, Killiany, Kennedy, Klaveness (bib0065) 2002; 33 Benjamini, Hochberg (bib0020) 1995; 57 Labuschagne, Phan, Wood, Angstadt, Chua, Heinrichs, Stout, Nathan (bib0175) 2010; 35 Meyer-Lindenberg, Domes, Kirsch, Heinrichs (bib0240) 2011; 12 Quintana, Alvares, Hickie, Guastella (bib0285) 2015; 49 Greve, Fischl (bib0090) 2009; 48 Neumann, Maloumby, Beiderbeck, Lukas, Landgraf (bib0255) 2013; 38 McRae-Clark, Baker, Moran-Santa Maria, Brady (bib0230) 2013; 228 Koch, van Zuiden, Nawijn, Frijling, Veltman, Olff (bib0170) 2014; 40 Whalen (bib0340) 2007; 11 Quintana, Westlye, Rustan, Tesli, Poppy, Smevik, Tesli, Røine, Mahmoud, Smerud, Djupesland, Andreassen (bib0290) 2015; 5 Ousdal, Jensen, Server, Hariri, Nakstad, Andreassen (bib0265) 2008; 156 Bethlehem, van Honk, Auyeung, Baron-Cohen (bib0025) 2013; 38 Bartz, Zaki, Bolger, Ochsner (bib0010) 2011; 15 Seeley, Menon, Schatzberg, Keller, Glover, Kenna, Reiss, Greicius (bib0300) 2007; 27 Frijling, van Zuiden, Koch, Nawijn, Veltman, Olff (bib0075) 2016; 41 Mayer-Hubner (bib0220) 1996; 347 Smith, Brady (bib0305) 1997; 23 Djupesland, Messina, Mahmoud (bib0045) 2014; 5 Hall, Lightbody, McCarthy, Parker, Reiss (bib0120) 2012; 37 Hollander, Novotny, Hanratty, Yaffe, DeCaria, Aronowitz, Mosovich (bib0125) 2003; 28 Smith, Jenkinson, Woolrich, Beckmann, Behrens, Johansen-Berg, Bannister, De Luca, Drobnjak, Flitney (bib0310) 2004; 23 Guastella, Hickie (bib0095) 2016; 79 Yatawara, Einfeld, Hickie, Davenport, Guastella (bib0355) 2015 Insel, Shapiro (bib0135) 1992; 89 Thorne, Pronk, Padmanabhan, Frey (bib0325) 2004; 127 Davis, Lee, Horan, Clarke, McGee, Green, Marder (bib0040) 2013; 147 Woolrich, Ripley, Brady, Smith (bib0345) 2001; 14 Lundqvist, Flykt, Öhman (bib0215) 1998 Quintana, Woolley (bib0280) 2016; 79 Domes, Heinrichs, Gläscher, Büchel, Braus, Herpertz (bib0055) 2007; 62 Insel (bib0140) 2016; 79 Dale, Nilsen, Loftsson, Tønnesen, Klepstad, Kaasa, Holand, Djupesland (bib0035) 2006; 58 Kirsch, Esslinger, Chen, Mier, Lis, Siddhanti, Gruppe, Mattay, Gallhofer, Meyer-Lindenberg (bib0160) 2005; 25 Popik, Vetulani, Van Ree (bib0275) 1992; 106 Lecrubier, Sheehan, Weiller, Amorim, Bonora, Harnett Sheehan, Janavs, Dunbar (bib0190) 1997; 12 Freeman, Inoue, Smith, Goodman, Young (bib0070) 2014; 45 Bakke, Samdal, Holst, Oftung, Haugen, Kristoffersen, Haugan, Janakova, Korsvold, Krogh (bib0005) 2006; 63 Knobloch, Charlet, Hoffmann, Eliava, Khrulev, Cetin, Osten, Schwarz, Seeburg, Stoop (bib0165) 2012; 73 Neumann, Landgraf (bib0250) 2012; 35 Gouin, Carter, Pournajafi-Nazarloo, Glaser, Malarkey, Loving, Stowell, Kiecolt-Glaser (bib0085) 2010; 35 Jenkinson, Bannister, Brady, Smith (bib0145) 2002; 17 Lane, Luminet, Nave, Mikolajczak (bib0180) 2016 Kanat, Heinrichs, Schwarzwald, Domes (bib0150) 2015; 40 Obaidi, Offman, Messina, Carothers, Djupesland, Mahmoud (bib0260) 2013; 53 Legros (bib0195) 2001; 26 McEwen (bib0225) 2004; 50 Guastella, Ward, Hickie, Shahrestani, Hodge, Scott, Langdon (bib0115) 2015; 168 Domes, Lischke, Berger, Grossmann, Hauenstein, Heinrichs, Herpertz (bib0060) 2010; 35 Sosulski, Bloom, Cutforth, Axel, Datta (bib0315) 2012; 472 Wetzels, Wagenmakers (bib0335) 2012; 19 LeDoux (bib0185) 2003; 23 Guastella, Hickie, McGuinness, Otis, Woods, Disinger, Chan, Chen, Banati (bib0110) 2013; 38 Tepper, Cady, Silberstein, Messina, Mahmoud, Djupesland, Shin, Siffert (bib0320) 2015; 55 Quintana, Guastella, Westlye, Andreassen (bib0295) 2016; 21 Cardoso, Ellenbogen, Orlando, Bacon, Joober (bib0030) 2013; 38 Guastella, MacLeod (bib0100) 2012; 61 Kemp, Guastella (bib0155) 2011; 20 Labuschagne (10.1016/j.psyneuen.2016.04.010_bib0175) 2010; 35 Djupesland (10.1016/j.psyneuen.2016.04.010_bib0045) 2014; 5 Koch (10.1016/j.psyneuen.2016.04.010_bib0170) 2014; 40 Obaidi (10.1016/j.psyneuen.2016.04.010_bib0260) 2013; 53 Guastella (10.1016/j.psyneuen.2016.04.010_bib0095) 2016; 79 Modi (10.1016/j.psyneuen.2016.04.010_bib0245) 2014; 45 Benjamini (10.1016/j.psyneuen.2016.04.010_bib0020) 1995; 57 Leknes (10.1016/j.psyneuen.2016.04.010_bib0200) 2012; 8 Kemp (10.1016/j.psyneuen.2016.04.010_bib0155) 2011; 20 Quintana (10.1016/j.psyneuen.2016.04.010_bib0285) 2015; 49 Hollander (10.1016/j.psyneuen.2016.04.010_bib0125) 2003; 28 LeDoux (10.1016/j.psyneuen.2016.04.010_bib0185) 2003; 23 Bakke (10.1016/j.psyneuen.2016.04.010_bib0005) 2006; 63 Neumann (10.1016/j.psyneuen.2016.04.010_bib0255) 2013; 38 Djupesland (10.1016/j.psyneuen.2016.04.010_bib0050) 2012; 3 Domes (10.1016/j.psyneuen.2016.04.010_bib0060) 2010; 35 Guastella (10.1016/j.psyneuen.2016.04.010_bib0100) 2012; 61 Yatawara (10.1016/j.psyneuen.2016.04.010_bib0355) 2015 Popik (10.1016/j.psyneuen.2016.04.010_bib0275) 1992; 106 Fischl (10.1016/j.psyneuen.2016.04.010_bib0065) 2002; 33 Sosulski (10.1016/j.psyneuen.2016.04.010_bib0315) 2012; 472 Lecrubier (10.1016/j.psyneuen.2016.04.010_bib0190) 1997; 12 Meyer-Lindenberg (10.1016/j.psyneuen.2016.04.010_bib0240) 2011; 12 Quintana (10.1016/j.psyneuen.2016.04.010_bib0290) 2015; 5 Tepper (10.1016/j.psyneuen.2016.04.010_bib0320) 2015; 55 Guastella (10.1016/j.psyneuen.2016.04.010_bib0110) 2013; 38 Jenkinson (10.1016/j.psyneuen.2016.04.010_bib0145) 2002; 17 Wetzels (10.1016/j.psyneuen.2016.04.010_bib0335) 2012; 19 Guastella (10.1016/j.psyneuen.2016.04.010_bib0115) 2015; 168 Hollander (10.1016/j.psyneuen.2016.04.010_bib0130) 2007; 61 Domes (10.1016/j.psyneuen.2016.04.010_bib0055) 2007; 62 Legros (10.1016/j.psyneuen.2016.04.010_bib0195) 2001; 26 Leng (10.1016/j.psyneuen.2016.04.010_bib0205) 2016; 79 Frijling (10.1016/j.psyneuen.2016.04.010_bib0075) 2016; 41 Quintana (10.1016/j.psyneuen.2016.04.010_bib0280) 2016; 79 Wechsler (10.1016/j.psyneuen.2016.04.010_bib0330) 1999 Gimpl (10.1016/j.psyneuen.2016.04.010_bib0080) 2001; 81 Merkus (10.1016/j.psyneuen.2016.04.010_bib0235) 2003; 60 Yamasue (10.1016/j.psyneuen.2016.04.010_bib0350) 2016; 70 Bartz (10.1016/j.psyneuen.2016.04.010_bib0010) 2011; 15 Greve (10.1016/j.psyneuen.2016.04.010_bib0090) 2009; 48 Kirsch (10.1016/j.psyneuen.2016.04.010_bib0160) 2005; 25 Lane (10.1016/j.psyneuen.2016.04.010_bib0180) 2016 Bethlehem (10.1016/j.psyneuen.2016.04.010_bib0025) 2013; 38 Lischke (10.1016/j.psyneuen.2016.04.010_bib0210) 2012; 37 Smith (10.1016/j.psyneuen.2016.04.010_bib0310) 2004; 23 Whalen (10.1016/j.psyneuen.2016.04.010_bib0340) 2007; 11 Neumann (10.1016/j.psyneuen.2016.04.010_bib0250) 2012; 35 Quintana (10.1016/j.psyneuen.2016.04.010_bib0295) 2016; 21 Hall (10.1016/j.psyneuen.2016.04.010_bib0120) 2012; 37 Insel (10.1016/j.psyneuen.2016.04.010_bib0135) 1992; 89 Seeley (10.1016/j.psyneuen.2016.04.010_bib0300) 2007; 27 Thorne (10.1016/j.psyneuen.2016.04.010_bib0325) 2004; 127 Benelli (10.1016/j.psyneuen.2016.04.010_bib0015) 1995; 28 Cardoso (10.1016/j.psyneuen.2016.04.010_bib0030) 2013; 38 Freeman (10.1016/j.psyneuen.2016.04.010_bib0070) 2014; 45 Mayer-Hubner (10.1016/j.psyneuen.2016.04.010_bib0220) 1996; 347 Insel (10.1016/j.psyneuen.2016.04.010_bib0140) 2016; 79 Woolrich (10.1016/j.psyneuen.2016.04.010_bib0345) 2001; 14 Smith (10.1016/j.psyneuen.2016.04.010_bib0305) 1997; 23 Knobloch (10.1016/j.psyneuen.2016.04.010_bib0165) 2012; 73 Lundqvist (10.1016/j.psyneuen.2016.04.010_bib0215) 1998 McRae-Clark (10.1016/j.psyneuen.2016.04.010_bib0230) 2013; 228 Davis (10.1016/j.psyneuen.2016.04.010_bib0040) 2013; 147 Kanat (10.1016/j.psyneuen.2016.04.010_bib0150) 2015; 40 Ousdal (10.1016/j.psyneuen.2016.04.010_bib0265) 2008; 156 Petrovic (10.1016/j.psyneuen.2016.04.010_bib0270) 2008; 28 Gouin (10.1016/j.psyneuen.2016.04.010_bib0085) 2010; 35 Guastella (10.1016/j.psyneuen.2016.04.010_bib0105) 2010; 67 McEwen (10.1016/j.psyneuen.2016.04.010_bib0225) 2004; 50 Dale (10.1016/j.psyneuen.2016.04.010_bib0035) 2006; 58 27613568 - Psychoneuroendocrinology. 2016 Nov;73:271-272. doi: 10.1016/j.psyneuen.2016.08.008. |
| References_xml | – volume: 60 start-page: 1669 year: 2003 end-page: 1671 ident: bib0235 article-title: Direct access of drugs to the human brain after intranasal drug administration? publication-title: Neurology – volume: 23 start-page: 45 year: 1997 end-page: 78 ident: bib0305 article-title: SUSAN—a new approach to low level image processing publication-title: Int. J. Comput. Vision – volume: 38 start-page: 1985 year: 2013 end-page: 1993 ident: bib0255 article-title: Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice publication-title: Psychoneuroendocrinology – volume: 37 start-page: 509 year: 2012 end-page: 518 ident: bib0120 article-title: Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome publication-title: Psychoneuroendocrinology – volume: 35 start-page: 1082 year: 2010 end-page: 1090 ident: bib0085 article-title: Marital behavior, oxytocin, vasopressin, and wound healing publication-title: Psychoneuroendocrinology – volume: 81 start-page: 629 year: 2001 end-page: 683 ident: bib0080 article-title: The oxytocin receptor system: structure function, and regulation publication-title: Physiol. Rev. – volume: 53 start-page: 1323 year: 2013 end-page: 1333 ident: bib0260 article-title: Improved pharmacokinetics of sumatriptan with Breath Powered™ nasal delivery of sumatriptan powder publication-title: Headache – volume: 23 start-page: S208 year: 2004 end-page: S219 ident: bib0310 article-title: Advances in functional and structural MR image analysis and implementation as FSL publication-title: Neuroimage – volume: 106 start-page: 71 year: 1992 end-page: 74 ident: bib0275 article-title: Low doses of oxytocin facilitate social recognition in rats publication-title: Psychopharmacology – volume: 37 start-page: 1431 year: 2012 end-page: 1438 ident: bib0210 article-title: Oxytocin increases amygdala reactivity to threatening scenes in females publication-title: Psychoneuroendocrinology – volume: 38 start-page: 962 year: 2013 end-page: 974 ident: bib0025 article-title: Oxytocin, brain physiology, and functional connectivity: a review of intranasal oxytocin fMRI studies publication-title: Psychoneuroendocrinology – volume: 70 start-page: 89 year: 2016 end-page: 99 ident: bib0350 article-title: Promising evidence and remaining issues regarding the clinical application of oxytocin in autism spectrum disorders publication-title: Psychiatry Clin. Neurosci. – volume: 11 start-page: 499 year: 2007 end-page: 500 ident: bib0340 article-title: The uncertainty of it all publication-title: Trends Cogn. Sci. – volume: 15 start-page: 301 year: 2011 end-page: 309 ident: bib0010 article-title: Social effects of oxytocin in humans: context and person matter publication-title: Trends Cogn. Sci. – volume: 62 start-page: 1187 year: 2007 end-page: 1190 ident: bib0055 article-title: Oxytocin attenuates amygdala responses to emotional faces regardless of valence publication-title: Biol. Psychiatry – volume: 19 start-page: 1057 year: 2012 end-page: 1064 ident: bib0335 article-title: A default Bayesian hypothesis test for correlations and partial correlations publication-title: Psychon. Bull. Rev. – volume: 17 start-page: 825 year: 2002 end-page: 841 ident: bib0145 article-title: Improved optimization for the robust and accurate linear registration and motion correction of brain images publication-title: Neuroimage – volume: 40 start-page: 287 year: 2015 end-page: 295 ident: bib0150 article-title: Oxytocin attenuates neural reactivity to masked threat cues from the eyes publication-title: Neuropsychopharmacology – volume: 28 start-page: 251 year: 1995 end-page: 255 ident: bib0015 article-title: Polymodal dose-response curve for oxytocin in the social recognition test publication-title: Neuropeptides – volume: 89 start-page: 5981 year: 1992 end-page: 5985 ident: bib0135 article-title: Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles publication-title: Proc. Natl. Acad. Sci. – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: bib0020 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J. R. Stat. Soc. B – year: 2015 ident: bib0355 article-title: The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: a randomized clinical crossover trial publication-title: Mol. Psychiatry – volume: 28 start-page: 193 year: 2003 end-page: 198 ident: bib0125 article-title: Oxytocin infusion reduces repetitive behaviors in adults with Autistic and Asperger's Disorders publication-title: Neuropsychopharmacology – volume: 472 start-page: 213 year: 2012 end-page: 216 ident: bib0315 article-title: Distinct representations of olfactory information in different cortical centres publication-title: Nature – volume: 33 start-page: 341 year: 2002 end-page: 355 ident: bib0065 article-title: Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain publication-title: Neuron – volume: 38 start-page: 399 year: 2013 end-page: 407 ident: bib0030 article-title: Intranasal oxytocin attenuates the cortisol response to physical stress: a dose–response study publication-title: Psychoneuroendocrinology – volume: 168 start-page: 628 year: 2015 end-page: 633 ident: bib0115 article-title: A single dose of oxytocin nasal spray improves higher-order social cognition in schizophrenia publication-title: Schizophr. Res. – year: 2016 ident: bib0180 article-title: Is there a publication bias in behavioral intranasal oxytocin research on humans? Opening the file drawer of one lab publication-title: J. Neuroendocrinol. – volume: 79 start-page: 243 year: 2016 end-page: 250 ident: bib0205 article-title: Intranasal oxytocin: myths and delusions publication-title: Biol. Psychiatry – volume: 55 start-page: 621 year: 2015 end-page: 635 ident: bib0320 article-title: AVP‐825 Breath‐Powered intranasal delivery system containing 22 publication-title: Headache – volume: 127 start-page: 481 year: 2004 end-page: 496 ident: bib0325 article-title: Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration publication-title: Neuroscience – volume: 35 start-page: 2403 year: 2010 end-page: 2413 ident: bib0175 article-title: Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder publication-title: Neuropsychopharmacology – volume: 347 start-page: 623 year: 1996 ident: bib0220 article-title: Pseudotumour cerebri from intranasal oxytocin and excessive fluid intake publication-title: Lancet – volume: 3 start-page: 42 year: 2012 end-page: 62 ident: bib0050 article-title: Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review publication-title: Drug Deliv. Transl. Res. – volume: 25 start-page: 11489 year: 2005 end-page: 11493 ident: bib0160 article-title: Oxytocin modulates neural circuitry for social cognition and fear in humans publication-title: J. Neurosci. – volume: 23 start-page: 727 year: 2003 end-page: 738 ident: bib0185 article-title: The emotional brain fear, and the amygdala publication-title: Cell. Mol. Neurobiol. – volume: 26 start-page: 649 year: 2001 end-page: 655 ident: bib0195 article-title: Inhibitory effect of oxytocin on corticotrope function in humans: are vasopressin and oxytocin ying–yang neurohormones? publication-title: Psychoneuroendocrinology – volume: 14 start-page: 1370 year: 2001 end-page: 1386 ident: bib0345 article-title: Temporal autocorrelation in univariate linear modeling of FMRI data publication-title: Neuroimage – volume: 5 start-page: 709 year: 2014 end-page: 733 ident: bib0045 article-title: The nasal approach to delivering treatment for brain diseases: an anatomic physiologic, and delivery technology overview publication-title: Ther. Deliv. – volume: 41 start-page: 1286 year: 2016 end-page: 1296 ident: bib0075 article-title: Intranasal oxytocin affects amygdala functional connectivity after trauma script-driven imagery in distressed recently trauma-exposed individuals publication-title: Neuropsychopharmacology – volume: 8 start-page: 741 year: 2012 end-page: 749 ident: bib0200 article-title: Oxytocin enhances pupil dilation and sensitivity to ‘hidden' emotional expressions publication-title: Soc. Cogn. Affect. Neurosci. – volume: 73 start-page: 553 year: 2012 end-page: 566 ident: bib0165 article-title: Evoked axonal oxytocin release in the central amygdala attenuates fear response publication-title: Neuron – volume: 38 start-page: 612 year: 2013 end-page: 625 ident: bib0110 article-title: Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research publication-title: Psychoneuroendocrinology – volume: 12 start-page: 224 year: 1997 end-page: 231 ident: bib0190 article-title: The Mini International Neuropsychiatric Interview (MINI). A short diagnostic structured interview: reliability and validity according to the CIDI publication-title: Eur. Psychiatry – year: 1998 ident: bib0215 article-title: The Karolinska Directed Emotional Faces (KDEF) – volume: 28 start-page: 6607 year: 2008 end-page: 6615 ident: bib0270 article-title: Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity publication-title: J. Neurosci. – volume: 49 start-page: 182 year: 2015 end-page: 192 ident: bib0285 article-title: Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model publication-title: Neurosci. Biobehav. Rev. – volume: 12 start-page: 524 year: 2011 end-page: 538 ident: bib0240 article-title: Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine publication-title: Nat. Rev. Neurosci. – volume: 67 start-page: 692 year: 2010 end-page: 694 ident: bib0105 article-title: Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders publication-title: Biol. Psychiatry – volume: 79 start-page: 153 year: 2016 end-page: 154 ident: bib0140 article-title: Translating oxytocin neuroscience to the clinic: a National Institute of Mental Health perspective publication-title: Biol. Psychiatry – volume: 61 start-page: 410 year: 2012 end-page: 418 ident: bib0100 article-title: A critical review of the influence of oxytocin nasal spray on social cognition in humans: evidence and future directions publication-title: Horm. Behav. – volume: 61 start-page: 498 year: 2007 end-page: 503 ident: bib0130 article-title: Oxytocin increases retention of social cognition in autism publication-title: Biol. Psychiatry – volume: 35 start-page: 83 year: 2010 end-page: 93 ident: bib0060 article-title: Effects of intranasal oxytocin on emotional face processing in women publication-title: Psychoneuroendocrinology – volume: 35 start-page: 649 year: 2012 end-page: 659 ident: bib0250 article-title: Balance of brain oxytocin and vasopressin: implications for anxiety depression, and social behaviors publication-title: Trends Neurosci. – volume: 27 start-page: 2349 year: 2007 end-page: 2356 ident: bib0300 article-title: Dissociable intrinsic connectivity networks for salience processing and executive control publication-title: J. Neurosci. – volume: 45 start-page: 128 year: 2014 end-page: 141 ident: bib0070 article-title: The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque ( publication-title: Psychoneuroendocrinology – volume: 5 start-page: 1 year: 2015 end-page: 9 ident: bib0290 article-title: Low dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized 4-way crossover trial with nasal cavity dimension assessment publication-title: Transl. Psychiatry – volume: 147 start-page: 393 year: 2013 end-page: 397 ident: bib0040 article-title: Effects of single dose intranasal oxytocin on social cognition in schizophrenia publication-title: Schizophr. Res. – volume: 40 start-page: 242 year: 2014 end-page: 256 ident: bib0170 article-title: Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: Salience processing and fear inhibition processes publication-title: Psychoneuroendocrinology – volume: 20 start-page: 222 year: 2011 end-page: 231 ident: bib0155 article-title: The role of oxytocin in human affect a novel hypothesis publication-title: Curr. Dir. Psychol. Sci. – volume: 48 start-page: 63 year: 2009 end-page: 72 ident: bib0090 article-title: Accurate and robust brain image alignment using boundary-based registration publication-title: Neuroimage – volume: 50 start-page: 531 year: 2004 end-page: 592 ident: bib0225 article-title: Brain–fluid barriers: relevance for theoretical controversies regarding vasopressin and oxytocin memory research publication-title: Adv. Pharmacol. – year: 1999 ident: bib0330 article-title: Weschsler Abbreviated Scale of Intelligence – volume: 21 start-page: 29 year: 2016 end-page: 38 ident: bib0295 article-title: The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders publication-title: Mol. Psychiatry – volume: 79 start-page: 234 year: 2016 end-page: 242 ident: bib0095 article-title: Oxytocin treatment, circuitry and autism: a critical review of the literature placing oxytocin into the autism context publication-title: Biol. Psychiatry – volume: 63 start-page: 223 year: 2006 end-page: 231 ident: bib0005 article-title: Oral spray immunization may be an alternative to intranasal vaccine delivery to induce systemic antibodies but not nasal mucosal or cellular immunity publication-title: Scand. J. Immunol. – volume: 45 start-page: 49 year: 2014 end-page: 57 ident: bib0245 article-title: Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques publication-title: Psychoneuroendocrinology – volume: 228 start-page: 623 year: 2013 end-page: 631 ident: bib0230 article-title: Effect of oxytocin on craving and stress response in marijuana-dependent individuals: a pilot study publication-title: Psychopharmacology – volume: 156 start-page: 450 year: 2008 end-page: 455 ident: bib0265 article-title: The human amygdala is involved in general behavioral relevance detection: evidence from an event-related functional magnetic resonance imaging Go-NoGo task publication-title: Neuroscience – volume: 58 start-page: 1311 year: 2006 end-page: 1318 ident: bib0035 article-title: Intranasal midazolam: a comparison of two delivery devices in human volunteers publication-title: J. Pharm. Pharmacol. – volume: 79 start-page: e49 year: 2016 end-page: e50 ident: bib0280 article-title: Intranasal oxytocin mechanisms can be better understood but its effects on social cognition and behavior are not to be sniffed at publication-title: Biol. Psychiatry – volume: 28 start-page: 193 year: 2003 ident: 10.1016/j.psyneuen.2016.04.010_bib0125 article-title: Oxytocin infusion reduces repetitive behaviors in adults with Autistic and Asperger's Disorders publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300021 – volume: 25 start-page: 11489 year: 2005 ident: 10.1016/j.psyneuen.2016.04.010_bib0160 article-title: Oxytocin modulates neural circuitry for social cognition and fear in humans publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3984-05.2005 – volume: 35 start-page: 649 year: 2012 ident: 10.1016/j.psyneuen.2016.04.010_bib0250 article-title: Balance of brain oxytocin and vasopressin: implications for anxiety depression, and social behaviors publication-title: Trends Neurosci. doi: 10.1016/j.tins.2012.08.004 – volume: 21 start-page: 29 year: 2016 ident: 10.1016/j.psyneuen.2016.04.010_bib0295 article-title: The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders publication-title: Mol. Psychiatry doi: 10.1038/mp.2015.166 – volume: 62 start-page: 1187 year: 2007 ident: 10.1016/j.psyneuen.2016.04.010_bib0055 article-title: Oxytocin attenuates amygdala responses to emotional faces regardless of valence publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2007.03.025 – volume: 49 start-page: 182 year: 2015 ident: 10.1016/j.psyneuen.2016.04.010_bib0285 article-title: Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2014.12.011 – volume: 33 start-page: 341 year: 2002 ident: 10.1016/j.psyneuen.2016.04.010_bib0065 article-title: Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain publication-title: Neuron doi: 10.1016/S0896-6273(02)00569-X – volume: 45 start-page: 128 year: 2014 ident: 10.1016/j.psyneuen.2016.04.010_bib0070 article-title: The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta) publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2014.03.023 – volume: 26 start-page: 649 year: 2001 ident: 10.1016/j.psyneuen.2016.04.010_bib0195 article-title: Inhibitory effect of oxytocin on corticotrope function in humans: are vasopressin and oxytocin ying–yang neurohormones? publication-title: Psychoneuroendocrinology doi: 10.1016/S0306-4530(01)00018-X – volume: 8 start-page: 741 year: 2012 ident: 10.1016/j.psyneuen.2016.04.010_bib0200 article-title: Oxytocin enhances pupil dilation and sensitivity to ‘hidden' emotional expressions publication-title: Soc. Cogn. Affect. Neurosci. doi: 10.1093/scan/nss062 – volume: 58 start-page: 1311 year: 2006 ident: 10.1016/j.psyneuen.2016.04.010_bib0035 article-title: Intranasal midazolam: a comparison of two delivery devices in human volunteers publication-title: J. Pharm. Pharmacol. doi: 10.1211/jpp.58.10.0003 – volume: 53 start-page: 1323 year: 2013 ident: 10.1016/j.psyneuen.2016.04.010_bib0260 article-title: Improved pharmacokinetics of sumatriptan with Breath Powered™ nasal delivery of sumatriptan powder publication-title: Headache doi: 10.1111/head.12167 – volume: 5 start-page: 1 year: 2015 ident: 10.1016/j.psyneuen.2016.04.010_bib0290 article-title: Low dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized 4-way crossover trial with nasal cavity dimension assessment publication-title: Transl. Psychiatry doi: 10.1038/tp.2015.93 – volume: 23 start-page: 45 year: 1997 ident: 10.1016/j.psyneuen.2016.04.010_bib0305 article-title: SUSAN—a new approach to low level image processing publication-title: Int. J. Comput. Vision doi: 10.1023/A:1007963824710 – volume: 11 start-page: 499 year: 2007 ident: 10.1016/j.psyneuen.2016.04.010_bib0340 article-title: The uncertainty of it all publication-title: Trends Cogn. Sci. doi: 10.1016/j.tics.2007.08.016 – volume: 12 start-page: 224 year: 1997 ident: 10.1016/j.psyneuen.2016.04.010_bib0190 article-title: The Mini International Neuropsychiatric Interview (MINI). A short diagnostic structured interview: reliability and validity according to the CIDI publication-title: Eur. Psychiatry doi: 10.1016/S0924-9338(97)83296-8 – volume: 41 start-page: 1286 year: 2016 ident: 10.1016/j.psyneuen.2016.04.010_bib0075 article-title: Intranasal oxytocin affects amygdala functional connectivity after trauma script-driven imagery in distressed recently trauma-exposed individuals publication-title: Neuropsychopharmacology doi: 10.1038/npp.2015.278 – volume: 81 start-page: 629 year: 2001 ident: 10.1016/j.psyneuen.2016.04.010_bib0080 article-title: The oxytocin receptor system: structure function, and regulation publication-title: Physiol. Rev. doi: 10.1152/physrev.2001.81.2.629 – volume: 35 start-page: 2403 year: 2010 ident: 10.1016/j.psyneuen.2016.04.010_bib0175 article-title: Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder publication-title: Neuropsychopharmacology doi: 10.1038/npp.2010.123 – volume: 19 start-page: 1057 year: 2012 ident: 10.1016/j.psyneuen.2016.04.010_bib0335 article-title: A default Bayesian hypothesis test for correlations and partial correlations publication-title: Psychon. Bull. Rev. doi: 10.3758/s13423-012-0295-x – volume: 89 start-page: 5981 year: 1992 ident: 10.1016/j.psyneuen.2016.04.010_bib0135 article-title: Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.89.13.5981 – volume: 79 start-page: 243 year: 2016 ident: 10.1016/j.psyneuen.2016.04.010_bib0205 article-title: Intranasal oxytocin: myths and delusions publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2015.05.003 – volume: 70 start-page: 89 year: 2016 ident: 10.1016/j.psyneuen.2016.04.010_bib0350 article-title: Promising evidence and remaining issues regarding the clinical application of oxytocin in autism spectrum disorders publication-title: Psychiatry Clin. Neurosci. doi: 10.1111/pcn.12364 – volume: 28 start-page: 251 year: 1995 ident: 10.1016/j.psyneuen.2016.04.010_bib0015 article-title: Polymodal dose-response curve for oxytocin in the social recognition test publication-title: Neuropeptides doi: 10.1016/0143-4179(95)90029-2 – volume: 79 start-page: e49 year: 2016 ident: 10.1016/j.psyneuen.2016.04.010_bib0280 article-title: Intranasal oxytocin mechanisms can be better understood but its effects on social cognition and behavior are not to be sniffed at publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2015.06.021 – volume: 168 start-page: 628 year: 2015 ident: 10.1016/j.psyneuen.2016.04.010_bib0115 article-title: A single dose of oxytocin nasal spray improves higher-order social cognition in schizophrenia publication-title: Schizophr. Res. doi: 10.1016/j.schres.2015.06.005 – volume: 40 start-page: 242 year: 2014 ident: 10.1016/j.psyneuen.2016.04.010_bib0170 article-title: Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: Salience processing and fear inhibition processes publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2013.11.018 – volume: 14 start-page: 1370 year: 2001 ident: 10.1016/j.psyneuen.2016.04.010_bib0345 article-title: Temporal autocorrelation in univariate linear modeling of FMRI data publication-title: Neuroimage doi: 10.1006/nimg.2001.0931 – volume: 38 start-page: 962 year: 2013 ident: 10.1016/j.psyneuen.2016.04.010_bib0025 article-title: Oxytocin, brain physiology, and functional connectivity: a review of intranasal oxytocin fMRI studies publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2012.10.011 – volume: 147 start-page: 393 year: 2013 ident: 10.1016/j.psyneuen.2016.04.010_bib0040 article-title: Effects of single dose intranasal oxytocin on social cognition in schizophrenia publication-title: Schizophr. Res. doi: 10.1016/j.schres.2013.04.023 – volume: 23 start-page: S208 year: 2004 ident: 10.1016/j.psyneuen.2016.04.010_bib0310 article-title: Advances in functional and structural MR image analysis and implementation as FSL publication-title: Neuroimage doi: 10.1016/j.neuroimage.2004.07.051 – volume: 79 start-page: 153 year: 2016 ident: 10.1016/j.psyneuen.2016.04.010_bib0140 article-title: Translating oxytocin neuroscience to the clinic: a National Institute of Mental Health perspective publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2015.02.002 – volume: 73 start-page: 553 year: 2012 ident: 10.1016/j.psyneuen.2016.04.010_bib0165 article-title: Evoked axonal oxytocin release in the central amygdala attenuates fear response publication-title: Neuron doi: 10.1016/j.neuron.2011.11.030 – volume: 156 start-page: 450 year: 2008 ident: 10.1016/j.psyneuen.2016.04.010_bib0265 article-title: The human amygdala is involved in general behavioral relevance detection: evidence from an event-related functional magnetic resonance imaging Go-NoGo task publication-title: Neuroscience doi: 10.1016/j.neuroscience.2008.07.066 – volume: 5 start-page: 709 year: 2014 ident: 10.1016/j.psyneuen.2016.04.010_bib0045 article-title: The nasal approach to delivering treatment for brain diseases: an anatomic physiologic, and delivery technology overview publication-title: Ther. Deliv. doi: 10.4155/tde.14.41 – volume: 61 start-page: 498 year: 2007 ident: 10.1016/j.psyneuen.2016.04.010_bib0130 article-title: Oxytocin increases retention of social cognition in autism publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2006.05.030 – volume: 347 start-page: 623 year: 1996 ident: 10.1016/j.psyneuen.2016.04.010_bib0220 article-title: Pseudotumour cerebri from intranasal oxytocin and excessive fluid intake publication-title: Lancet doi: 10.1016/S0140-6736(96)91325-2 – volume: 12 start-page: 524 year: 2011 ident: 10.1016/j.psyneuen.2016.04.010_bib0240 article-title: Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3044 – volume: 3 start-page: 42 year: 2012 ident: 10.1016/j.psyneuen.2016.04.010_bib0050 article-title: Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review publication-title: Drug Deliv. Transl. Res. doi: 10.1007/s13346-012-0108-9 – year: 1999 ident: 10.1016/j.psyneuen.2016.04.010_bib0330 – volume: 55 start-page: 621 year: 2015 ident: 10.1016/j.psyneuen.2016.04.010_bib0320 article-title: AVP‐825 Breath‐Powered intranasal delivery system containing 22mg Sumatriptan Powder vs 100mg oral sumatriptan in the acute treatment of migraines (The COMPASS Study): a comparative randomized clinical trial across multiple attacks publication-title: Headache doi: 10.1111/head.12583 – volume: 79 start-page: 234 year: 2016 ident: 10.1016/j.psyneuen.2016.04.010_bib0095 article-title: Oxytocin treatment, circuitry and autism: a critical review of the literature placing oxytocin into the autism context publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2015.06.028 – volume: 20 start-page: 222 year: 2011 ident: 10.1016/j.psyneuen.2016.04.010_bib0155 article-title: The role of oxytocin in human affect a novel hypothesis publication-title: Curr. Dir. Psychol. Sci. doi: 10.1177/0963721411417547 – volume: 35 start-page: 1082 year: 2010 ident: 10.1016/j.psyneuen.2016.04.010_bib0085 article-title: Marital behavior, oxytocin, vasopressin, and wound healing publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2010.01.009 – volume: 48 start-page: 63 year: 2009 ident: 10.1016/j.psyneuen.2016.04.010_bib0090 article-title: Accurate and robust brain image alignment using boundary-based registration publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.06.060 – volume: 228 start-page: 623 year: 2013 ident: 10.1016/j.psyneuen.2016.04.010_bib0230 article-title: Effect of oxytocin on craving and stress response in marijuana-dependent individuals: a pilot study publication-title: Psychopharmacology doi: 10.1007/s00213-013-3062-4 – volume: 15 start-page: 301 year: 2011 ident: 10.1016/j.psyneuen.2016.04.010_bib0010 article-title: Social effects of oxytocin in humans: context and person matter publication-title: Trends Cogn. Sci. – volume: 23 start-page: 727 year: 2003 ident: 10.1016/j.psyneuen.2016.04.010_bib0185 article-title: The emotional brain fear, and the amygdala publication-title: Cell. Mol. Neurobiol. doi: 10.1023/A:1025048802629 – volume: 38 start-page: 612 year: 2013 ident: 10.1016/j.psyneuen.2016.04.010_bib0110 article-title: Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2012.11.019 – volume: 57 start-page: 289 year: 1995 ident: 10.1016/j.psyneuen.2016.04.010_bib0020 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J. R. Stat. Soc. B doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 67 start-page: 692 year: 2010 ident: 10.1016/j.psyneuen.2016.04.010_bib0105 article-title: Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2009.09.020 – volume: 38 start-page: 1985 year: 2013 ident: 10.1016/j.psyneuen.2016.04.010_bib0255 article-title: Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2013.03.003 – volume: 63 start-page: 223 year: 2006 ident: 10.1016/j.psyneuen.2016.04.010_bib0005 article-title: Oral spray immunization may be an alternative to intranasal vaccine delivery to induce systemic antibodies but not nasal mucosal or cellular immunity publication-title: Scand. J. Immunol. doi: 10.1111/j.1365-3083.2006.01730.x – volume: 37 start-page: 1431 year: 2012 ident: 10.1016/j.psyneuen.2016.04.010_bib0210 article-title: Oxytocin increases amygdala reactivity to threatening scenes in females publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2012.01.011 – volume: 38 start-page: 399 year: 2013 ident: 10.1016/j.psyneuen.2016.04.010_bib0030 article-title: Intranasal oxytocin attenuates the cortisol response to physical stress: a dose–response study publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2012.07.013 – volume: 40 start-page: 287 year: 2015 ident: 10.1016/j.psyneuen.2016.04.010_bib0150 article-title: Oxytocin attenuates neural reactivity to masked threat cues from the eyes publication-title: Neuropsychopharmacology doi: 10.1038/npp.2014.183 – volume: 106 start-page: 71 year: 1992 ident: 10.1016/j.psyneuen.2016.04.010_bib0275 article-title: Low doses of oxytocin facilitate social recognition in rats publication-title: Psychopharmacology doi: 10.1007/BF02253591 – volume: 27 start-page: 2349 year: 2007 ident: 10.1016/j.psyneuen.2016.04.010_bib0300 article-title: Dissociable intrinsic connectivity networks for salience processing and executive control publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5587-06.2007 – volume: 45 start-page: 49 year: 2014 ident: 10.1016/j.psyneuen.2016.04.010_bib0245 article-title: Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2014.02.011 – volume: 61 start-page: 410 year: 2012 ident: 10.1016/j.psyneuen.2016.04.010_bib0100 article-title: A critical review of the influence of oxytocin nasal spray on social cognition in humans: evidence and future directions publication-title: Horm. Behav. doi: 10.1016/j.yhbeh.2012.01.002 – year: 2015 ident: 10.1016/j.psyneuen.2016.04.010_bib0355 article-title: The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: a randomized clinical crossover trial publication-title: Mol. Psychiatry – volume: 472 start-page: 213 year: 2012 ident: 10.1016/j.psyneuen.2016.04.010_bib0315 article-title: Distinct representations of olfactory information in different cortical centres publication-title: Nature doi: 10.1038/nature09868 – year: 2016 ident: 10.1016/j.psyneuen.2016.04.010_bib0180 article-title: Is there a publication bias in behavioral intranasal oxytocin research on humans? Opening the file drawer of one lab publication-title: J. Neuroendocrinol. doi: 10.1111/jne.12384 – volume: 37 start-page: 509 year: 2012 ident: 10.1016/j.psyneuen.2016.04.010_bib0120 article-title: Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2011.07.020 – volume: 35 start-page: 83 year: 2010 ident: 10.1016/j.psyneuen.2016.04.010_bib0060 article-title: Effects of intranasal oxytocin on emotional face processing in women publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2009.06.016 – year: 1998 ident: 10.1016/j.psyneuen.2016.04.010_bib0215 – volume: 127 start-page: 481 year: 2004 ident: 10.1016/j.psyneuen.2016.04.010_bib0325 article-title: Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration publication-title: Neuroscience doi: 10.1016/j.neuroscience.2004.05.029 – volume: 17 start-page: 825 year: 2002 ident: 10.1016/j.psyneuen.2016.04.010_bib0145 article-title: Improved optimization for the robust and accurate linear registration and motion correction of brain images publication-title: Neuroimage doi: 10.1006/nimg.2002.1132 – volume: 28 start-page: 6607 year: 2008 ident: 10.1016/j.psyneuen.2016.04.010_bib0270 article-title: Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4572-07.2008 – volume: 50 start-page: 531 year: 2004 ident: 10.1016/j.psyneuen.2016.04.010_bib0225 article-title: Brain–fluid barriers: relevance for theoretical controversies regarding vasopressin and oxytocin memory research publication-title: Adv. Pharmacol. doi: 10.1016/S1054-3589(04)50014-5 – volume: 60 start-page: 1669 year: 2003 ident: 10.1016/j.psyneuen.2016.04.010_bib0235 article-title: Direct access of drugs to the human brain after intranasal drug administration? publication-title: Neurology doi: 10.1212/01.WNL.0000067993.60735.77 – reference: 27613568 - Psychoneuroendocrinology. 2016 Nov;73:271-272. doi: 10.1016/j.psyneuen.2016.08.008. |
| SSID | ssj0006862 |
| Score | 2.4648852 |
| Snippet | •8IU intranasal oxytocin (OT) treatment dampens amygdala activation in response to emotional faces.•Intravenous OT treatment did not produce these effects,... Highlights • 8IU intranasal oxytocin (OT) treatment dampens amygdala activation in response to emotional faces. • Intravenous OT treatment did not produce... It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social behavior and cognition and what is the optimal dose for OT response. To... |
| SourceID | cristin proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 180 |
| SubjectTerms | Administration, Intranasal Adult Amygdala - drug effects Blood-Brain Barrier - metabolism Brain - metabolism Cognition - drug effects Cognition - physiology Cross-Over Studies Dose-response Dose-Response Relationship, Drug Double-Blind Method Emotions - physiology Endocrinology & Metabolism Facial Expression Facial Recognition - drug effects fMRI Humans Intranasal Intravenous Magnetic Resonance Imaging Male Oxytocin Oxytocin - metabolism Oxytocin - pharmacology Psychiatry Social Behavior Young Adult |
| Title | Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0306453016301007 https://www.clinicalkey.es/playcontent/1-s2.0-S0306453016301007 https://dx.doi.org/10.1016/j.psyneuen.2016.04.010 https://www.ncbi.nlm.nih.gov/pubmed/27107209 https://www.proquest.com/docview/1791741902 https://www.proquest.com/docview/1808630178 http://hdl.handle.net/10852/53219 |
| Volume | 69 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELemIRAvCDZg5WMyEuItNHHsOOGtTEwdsAkBk_Zm2fVldGqdaWkF5YG_jj-Mu3wUEBogeOhDozh24rvz7-zf3TH2WCIqjkuXRK5IJ5EscC6slUXkhNalyr2OXcO2OMrGx_LliTrZYHt9LAzRKjvb39r0xlp3V4bd1xyeT6fDd4R2pUIBzfDXRpRLqUnKn375TvOgCIj2JCGL6O4fooTP0BFdBVgC5UFNsiblKUXSXp00-hUuW6oug6LNkrR_k93osCQftcO9xTYgbLHtUUA_er7iT3jD7my2zbfYtcPuEH2bfX1dfeS-qoFPaWc32BofUn1aLXCeAvcwI6oGeE5btPw5gcoP_A0VU8NrHsiycG8RbYea2_nq1NuZ5Rct1Rb4ouLQVgbCh-LrEfvqGR9xSqjcZDCY8ZZCEnUk-VnX0zRE9dLRrlDNcVC-mk8_U4c4zmj99PLw7QFvCo3cZsf7L97vjaOumEM0UXm6iEAkWa5LRIi5cKn1iQJtS5E7JbwrMtDoK-eFcE6lqnSiyDVkAFTzMHMIkkR6h22GKsAO47EFBFbSoaekpMdmHtfUDHJAb9AnNhuwnW4GTUA9ohyoShiVonEeMNVPqZl0SdCpFsfM9Gy3M9MLhSGhMLE0KBQDNly3O2_TgPyxhe4lxvRBrmiWDa5U_9YS6s661CYxtTCx-UUDBqxYt_xJif6q10e9WBu0MHRsZANUS-xNo0svETiK39yTo2uMg9D5gN1tdWL9nQSCWC3i4t5_jO4-u07_Wp70A7a5uFjCQ0SDC7fbqPsuuzI6eDU--gaoSGIy |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELemTny8INiAlU8jId6iJk4cJ7yViallbYVgk_Zm2bUzMrXOtLSC8vfxh3GXOBUIDRA89CXt2df47vw7-z4IeZkAKg4LHQU6j-dBksNaKJXkgWZCFDwzItRNtMUsHZ0m78742Q457HJhMKzS2_7WpjfW2j8Z-Lc5uCzLwUdEuwkHAU3h02SU72J1Kt4ju8Px8Wi2NciYBNFeJqQBEvyQKHwBvujG2bXFUqhR2lQ9xWTaG_NGxdx1u9V1aLTZlY7ukjseTtJhy_E9smPdHtkfOnCllxv6ijYBns3J-R65OfX36Pvk26T6TE1VW1ri4a5TNQxSfdmsYKkcNXaB0RrWUDylpW8QV36i77GfGjwzFo0LNQoAt6upWm7OjVooetVG21q6qqhtmwPBoPD3MADrNR1SrKncFDFY0DaKJPBx8gs_U-mCeq3xYKimwJSpluVXnBD4DLajF9MPY9r0GrlPTo_enhyOAt_PIZjzLF4FlkVpJgoAiRnTsTIRt0IVLNOcGZ2nVoC7nOVMax7zQrM8Eza1FtsephpwEosfkJ6rnD0gNFQWsFWiwVniiQEyA9tqajMLDqGJVNonB34FpQNVwjKonEkeg33uE94tqZz7OujYjmMhu4C3C9kJhUShkGEiQSj6ZLClu2wrgfyRQnQSI7s8V7DMEjarf6O0tTcwtYxkzWQof1GCPsm3lD_p0V_N-qITawlGBm-OlLPVGmYT4NUngB3Zb36TgXcMTIisTx62OrF9TwxwrGBh_ug_uHtObo1OphM5Gc-OH5Pb-E0bNv2E9FZXa_sUwOFKP_PK_x2PdmTj |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Low+dose+intranasal+oxytocin+delivered+with+Breath+Powered+device+dampens+amygdala+response+to+emotional+stimuli%3A+A+peripheral+effect-controlled+within-subjects+randomized+dose-response+fMRI+trial&rft.jtitle=Psychoneuroendocrinology&rft.au=Quintanaa%2C+Daniel+S&rft.au=Westlyea%2C+Lars+T&rft.au=Alnaesa%2C+Dag&rft.au=Rustana%2C+Oeyvind+G&rft.date=2016-07-01&rft.issn=0306-4530&rft.volume=69&rft.spage=180&rft.epage=188&rft_id=info:doi/10.1016%2Fj.psyneuen.2016.04.010&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0306-4530&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0306-4530&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0306-4530&client=summon |