Biofilms in Chronic Wounds: Pathogenesis and Diagnosis

• Published in: Trends in biotechnology (Regular ed.) Vol. 37; no. 5; pp. 505 - 517
• Main Authors: Wu, Yuan-Kun, Cheng, Nai-Chen, Cheng, Chao-Min
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2019; Elsevier Limited
• Subjects: Animals; Antibiotics; Bacteria; Bacteria - pathogenicity; Bacterial Infections - diagnosis; Bacterial Infections - microbiology; Bacterial Infections - pathology; biofilm; Biofilms; Biomedical Research; Biopsy; Biotechnology; Chemokines; Chronic Disease; Chronic infection; chronic wound; Cytokines; Deoxyribonucleic acid; Diagnosis; Diagnostic systems; DNA; Growth factors; Humans; Identification; Infections; Ligands; Localization; Medical laboratories; Methods; Mice; Microbiology; Microscopy; Morphology; Neutrophils; Pathogenesis; Peptides; point-of-care systems; Prostheses; transcriptomics; Tumor necrosis factor-TNF; Ulcers; wound blotting; Wound Healing; Wound infection; Wound Infection - diagnosis; Wound Infection - microbiology; Wound Infection - pathology; diagnosis; wound blotting; chronic wound; biofilm

Chronic non-healing wounds have become a major worldwide healthcare burden. The impact of biofilms on chronic wound infection is well established. Despite increasing understanding of the underlying mechanism of biofilm formation in chronic wounds, current strategies for biofilm diagnosis in chronic...