Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde

• Published in: Toxicology (Amsterdam) Vol. 252; no. 1; pp. 40 - 48
• Main Authors: Costa, Solange, Coelho, Patrícia, Costa, Carla, Silva, Susana, Mayan, Olga, Santos, Luís Silva, Gaspar, Jorge, Teixeira, João Paulo
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 30.10.2008; Amsterdam Elsevier Science
• Subjects: Adult; Air - analysis; Anatomy; Animals; Biological and medical sciences; Biomarkers; Comet Assay; DNA Damage; DNA Repair - drug effects; Emergency; Environmental Monitoring; Female; Formaldehyde; Formaldehyde - toxicity; Genotype; Humans; Lymphocytes - drug effects; Lymphocytes - ultrastructure; Male; Medical Laboratory Personnel; Medical sciences; Micronuclei; Micronucleus Tests; Middle Aged; Mutagens - toxicity; Occupational Exposure - adverse effects; Pathology; Pathology anatomy workers; Sex Characteristics; Sister Chromatid Exchange; Sister chromatid exchanges; Smoking - metabolism; Toxicology; Xenobiotics - metabolism; Young Adult; Pathology anatomy workers; Sister chromatid exchanges; Micronuclei; Formaldehyde; Comet assay; Human; Toxicity; Sister chromatid exchange; Genotoxicity; Laboratory; Anatomy; Occupational exposure; Anatomic pathology; Micronucleus; Worker; Lesion; Occupational medicine

Formaldehyde (FA) is a chemical traditionally used in pathology and anatomy laboratories as a tissue preservative. Several epidemiological studies of occupational exposure to FA have indicated an increased risk of nasopharyngeal cancers in industrial workers, embalmers and pathology anatomists. Ther...