Protein residue network analysis reveals fundamental properties of the human coagulation factor VIII

• Published in: Scientific reports Vol. 11; no. 1; pp. 12625 - 11
• Main Authors: Lopes, Tiago J. S., Rios, Ricardo, Nogueira, Tatiane, Mello, Rodrigo F.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.06.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114/1305; 631/114/2408; 631/114/663; 631/45/612/1221; 692/699/1541; Amino acids; Biological properties; Blood coagulation; Coagulation; Coagulation factor VIII; Coagulation factors; Factor VIII deficiency; Hemophilia; Humanities and Social Sciences; multidisciplinary; Prophylaxis; Protein structure; Proteins; Residues; Science; Science (multidisciplinary)

Hemophilia A is an X-linked inherited blood coagulation disorder caused by the production and circulation of defective coagulation factor VIII protein. People living with this condition receive either prophylaxis or on-demand treatment, and approximately 30% of patients develop inhibitor antibodies,...