c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

• Published in: Nature communications Vol. 11; no. 1; pp. 4980 - 12
• Main Authors: Feng, Yu Chen, Liu, Xiao Ying, Teng, Liu, Ji, Qiang, Wu, Yongyan, Li, Jin Ming, Gao, Wei, Zhang, Yuan Yuan, La, Ting, Tabatabaee, Hessam, Yan, Xu Guang, Jamaluddin, M. Fairuz B., Zhang, Didi, Guo, Su Tang, Scott, Rodney J., Liu, Tao, Thorne, Rick F., Zhang, Xu Dong, Jin, Lei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.10.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 13/105; 13/106; 13/109; 13/2; 13/31; 13/89; 14/19; 14/32; 38/15; 38/70; 38/91; 45/71; 45/77; 631/337/384/2568; 631/67/1347; 631/67/1612; 631/67/395; 96/1; c-Myc protein; Cancer; Cell proliferation; Cell survival; Deactivation; Homeostasis; Homology; Humanities and Social Sciences; Inactivation; MDM2 protein; miRNA; multidisciplinary; Myc protein; Negative feedback; p53 Protein; Pathogenesis; Ribonucleic acid; RNA; Science; Science (multidisciplinary); SUMO protein; Survival; Transcription; Tumor suppressor genes; Tumorigenicity; Tumors

The functions of the proto-oncoprotein c-Myc and the tumor suppressor p53 in controlling cell survival and proliferation are inextricably linked as “Yin and Yang” partners in normal cells to maintain tissue homeostasis: c-Myc induces the expression of ARF tumor suppressor (p14 ARF in human and p19 A...