USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer

• Published in: Nature communications Vol. 13; no. 1; pp. 5644 - 18
• Main Authors: Shi, Dongni, Wu, Xianqiu, Jian, Yunting, Wang, Junye, Huang, Chengmei, Mo, Shuang, Li, Yue, Li, Fengtian, Zhang, Chao, Zhang, Dongsheng, Zhang, Huizhong, Huang, Huilin, Chen, Xin, Wang, Y. Alan, Lin, Chuyong, Liu, Guozhen, Song, Libing, Liao, Wenting
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.09.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/31; 13/51; 14/5; 38/1; 42/89; 631/67/2327; 64/60; 692/4028/67/1504/1885/1393; 692/4028/67/327; 82/80; Cancer; Cancer immunotherapy; Clinical trials; Colorectal cancer; Colorectal carcinoma; Cytotoxicity; Dioxygenase; Humanities and Social Sciences; Immunotherapy; Lymphocytes; Lymphocytes T; Metabolism; Microenvironments; multidisciplinary; PD-1 protein; Post-transcription; Post-translation; Proteasomes; Regulatory mechanisms (biology); Science; Science (multidisciplinary); Therapeutic targets; Tryptophan; Tumor microenvironment; Tumors

Indoleamine 2,3 dioxygenase 1 (IDO1) is an attractive target for cancer immunotherapy. However, IDO1 inhibitors have shown disappointing therapeutic efficacy in clinical trials, mainly because of the activation of the aryl hydrocarbon receptor (AhR). Here, we show a post-transcriptional regulatory m...