Highly conserved shifts in ubiquitin-proteasome system (UPS) activity drive mitochondrial remodeling during quiescence

• Published in: Nature communications Vol. 13; no. 1; pp. 4462 - 14
• Main Authors: Yue, Sibiao, Wang, Lei, DeMartino, George N., Zhao, FangZhou, Liu, Yi, Sieber, Matthew H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 13/89; 14/19; 631/136/2434/1706; 631/337/474; 631/80/642/333; 64/24; 82/58; 82/83; 96/10; 96/63; Age; Age related diseases; Cancer; Fatty acids; Gametocytes; Homeostasis; Humanities and Social Sciences; Infertility; Membrane proteins; Metabolism; Mitochondria; multidisciplinary; Oocytes; Outer membrane proteins; Oxidation; Proteasomes; Proteomes; Recruitment; Science; Science (multidisciplinary); Stem cells; Substrates; Ubiquitin; Ubiquitination

Defects in cellular proteostasis and mitochondrial function drive many aspects of infertility, cancer, and other age-related diseases. All of these conditions rely on quiescent cells, such as oocytes and adult stem cells, that reduce their activity and remain dormant as part of their roles in tissue...