Regulatory properties of vitronectin and its glycosylation in collagen fibril formation and collagen-degrading enzyme cathepsin K activity

• Published in: Scientific reports Vol. 11; no. 1; p. 12023
• Main Authors: Date, Kimie, Sakagami, Hiromi, Yura, Kei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.06.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/337; 631/45; Bone resorption; Cathepsin K; Cathepsins; Collagen; Extracellular matrix; Fibers; Glycosylation; Humanities and Social Sciences; Molecular modelling; multidisciplinary; Osteoarthritis; Osteoporosis; Scanning electron microscopy; Science; Science (multidisciplinary); Solubilization; Vitronectin

Vitronectin (VN) is a glycoprotein found in extracellular matrix and blood. Collagen, a major extracellular matrix component in mammals, is degraded by cathepsin K (CatK), which is essential for bone resorption under acidic conditions. The relationship between VN and cathepsins has been unclear. We...