Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration

• Published in: Nature biotechnology Vol. 36; no. 4; pp. 328 - 337
• Main Authors: da Cruz, Lyndon, Fynes, Kate, Georgiadis, Odysseas, Kerby, Julie, Luo, Yvonne H, Ahmado, Ahmad, Vernon, Amanda, Daniels, Julie T, Nommiste, Britta, Hasan, Shazeen M, Gooljar, Sakina B, Carr, Amanda-Jayne F, Vugler, Anthony, Ramsden, Conor M, Bictash, Magda, Fenster, Mike, Steer, Juliette, Harbinson, Tricia, Wilbrey, Anna, Tufail, Adnan, Feng, Gang, Whitlock, Mark, Robson, Anthony G, Holder, Graham E, Sagoo, Mandeep S, Loudon, Peter T, Whiting, Paul, Coffey, Peter J
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.04.2018; Nature Publishing Group
• Subjects: 13; 13/1; 14; 14/63; 59; 631/61/490; 692/308/2171; Acuity; Age; Age related diseases; Aged; Agriculture; Animals; Basement Membrane - diagnostic imaging; Basement Membrane - growth & development; Bioinformatics; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Blindness; Care and treatment; Cell Differentiation - genetics; Embryonic stem cells; Epithelium; Feasibility studies; Female; Health aspects; Human Embryonic Stem Cells - transplantation; Humans; Immunosuppression; Life Sciences; Macular degeneration; Macular Degeneration - diagnostic imaging; Macular Degeneration - pathology; Macular Degeneration - therapy; Male; Methods; Mice; Middle Aged; Optical Coherence Tomography; Patients; Retina; Retinal pigment epithelium; Retinal Pigment Epithelium - diagnostic imaging; Retinal Pigment Epithelium - growth & development; Retinal Pigment Epithelium - transplantation; Safety; Stem cell transplantation; Stem Cell Transplantation - adverse effects; Stem cells; Surgical instruments; Swine; Tomography, Optical Coherence; Transplantation; Tumorigenicity; Visual acuity; Visual Acuity - physiology

An engineered patch of retinal pigment epithelium generated from human embryonic stem cells is transplanted into the eyes of two patients. Age-related macular degeneration (AMD) remains a major cause of blindness, with dysfunction and loss of retinal pigment epithelium (RPE) central to disease progr...