Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration - da Cruz, Lyndon; Fynes, Kate; Georgiadis, Odysseas; Kerby, Julie; Luo, Yvonne H; Ahmado, Ahmad; Vernon, Amanda; Daniels, Julie T; Nommiste, Britta; Hasan, Shazeen M; Gooljar, Sakina B; Carr, Amanda-Jayne F; et al. (Nature biotechnology, 2018)
Keywords: 13; 13/1; 14; 14/63; 59; 631/61/490; 692/308/2171; Acuity; Age; Age related diseases; Aged; Agriculture; Animals; Basement Membrane - diagnostic imaging; Basement Membrane - growth & development; Bioinformatics; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Blindness; Care and treatment; Cell Differentiation - genetics; Embryonic stem cells; Epithelium; Feasibility studies; Female; Health aspects; Human Embryonic Stem Cells - transplantation; Humans; Immunosuppression; Life Sciences; Macular degeneration; Macular Degeneration - diagnostic imaging; Macular Degeneration - pathology; Macular Degeneration - therapy; Male; Methods; Mice; Middle Aged; Optical Coherence Tomography; Patients; Retina; Retinal pigment epithelium; Retinal Pigment Epithelium - diagnostic imaging; Retinal Pigment Epithelium - growth & development; Retinal Pigment Epithelium - transplantation; Safety; Stem cell transplantation; Stem Cell Transplantation - adverse effects; Stem cells; Surgical instruments; Swine; Tomography, Optical Coherence; Transplantation; Tumorigenicity; Visual acuity; Visual Acuity - physiology