The foundations and development of lipidomics

• Published in: Journal of lipid research Vol. 63; no. 2; p. 100164
• Main Authors: Han, Xianlin, Gross, Richard W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2022; American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: Animals; charge-switch derivatization; chromatographic separation; electrospray ionization; Humans; Lipid Metabolism; Lipidomics - methods; lipids; Lipids - analysis; Lipids - chemistry; mass spectrometry; matrix-assisted laser desorption/ionization; shotgun lipidomics; soft ionization; Thematic Review Series; lipids; PS; MDMS-SL; lipid metabolism; chromatographic separation; electrospray ionization; soft ionization; PC; matrix-assisted laser desorption/ionization; shotgun lipidomics; mass spectrometry; PI; charge-switch derivatization; CID

For over a century, the importance of lipid metabolism in biology was recognized but difficult to mechanistically understand due to the lack of sensitive and robust technologies for identification and quantification of lipid molecular species. The enabling technological breakthroughs emerged in the...