Potential role of senescent macrophages in radiation-induced pulmonary fibrosis

• Published in: Cell death & disease Vol. 12; no. 6; pp. 527 - 12
• Main Authors: Su, Lulu, Dong, Yinping, Wang, Yueying, Wang, Yuquan, Guan, Bowen, Lu, Yanhua, Wu, Jing, Wang, Xiaochun, Li, Deguan, Meng, Aimin, Fan, Feiyue
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.05.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/21; 13/31; 13/51; 14/19; 14/63; 38/1; 38/77; 38/90; 631/250/127/98; 631/80/509; 64/60; 82/80; Antibodies; Bcl-2 protein; Bcl-x protein; Biochemistry; Biomedical and Life Sciences; Bone marrow; Cell Biology; Cell Culture; Chemokines; CXCL10 protein; Epithelial cells; Fibroblasts; Fibrosis; Gelatinase A; Gelatinase B; Immunology; Inflammation; Interleukin 6; Ionizing radiation; Life Sciences; Lung diseases; Macrophages; Matrix metalloproteinase; Monocyte chemoattractant protein 1; Monocytes; Phenotypes; Pulmonary fibrosis; Radiation; Senescence; Toxicity; Transforming growth factor-b1; Tumor necrosis factor-α; β-Galactosidase

Radiation-induced pulmonary fibrosis (RIPF) is a late toxicity of therapeutic radiation in clinic with poor prognosis and limited therapeutic options. Previous results have shown that senescent cells, such as fibroblast and type II airway epithelial cell, are strongly implicated in pathology of RIPF...