Regulation and termination of NADPH oxidase activity

• Published in: Cellular and molecular life sciences : CMLS Vol. 62; no. 19-20; pp. 2173 - 2193
• Main Authors: DeCoursey, T. E., Ligeti, E.
• Format: Journal Article
• Language: English
• Published: Switzerland Springer Nature B.V 01.10.2005; Birkhäuser-Verlag
• Subjects: Damage prevention; Deactivation; Enzyme Activation; Enzymes; Humans; Immunology; Leukocytes; Leukocytes (neutrophilic); NAD(P)H oxidase; NADPH Oxidases - chemistry; NADPH Oxidases - metabolism; Nucleotides; Oxidase; Phagocytes; Phagocytes - enzymology; Phosphorylation; Proteins; Protons; Reactive oxygen species; Respiratory Burst; Respiratory burst oxidase; Review; Substrate Specificity; Superoxides - metabolism

NADPH oxidase of phagocytes plays a crucial role in host defense by producing reactive oxygen species (ROS) that are intended to kill invading microbes. Many other cells produce ROS for signaling purposes. The respiratory burst oxidase in human neutrophils is the main but not exclusive subject of th...