Enteric Neuronal Density Contributes to the Severity of Intestinal Inflammation

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 141; no. 2; pp. 588 - 598.e2
• Main Authors: Margolis, Kara Gross, Stevanovic, Korey, Karamooz, Nima, Li, Zi Shan, Ahuja, Ankur, D'Autréaux, Fabien, Saurman, Virginia, Chalazonitis, Alcmene, Gershon, Michael David
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2011
• Subjects: Animals; Basic Helix-Loop-Helix Transcription Factors - metabolism; Carrier Proteins - metabolism; Colitis; Colitis - chemically induced; Colitis - genetics; Colitis - metabolism; Colitis - pathology; Crohn's Disease; Dextran Sulfate; Dinitrofluorobenzene; Enteric Nervous System - metabolism; Enteric Nervous System - pathology; Female; Gastroenterology and Hepatology; Hypersensitivity, Delayed - chemically induced; Hypersensitivity, Delayed - metabolism; IBD; Interferon-gamma - metabolism; Interleukin-1beta - metabolism; Leukocyte Elastase - metabolism; Male; Mice; Neurons - metabolism; Neurons - pathology; Neutrophils - metabolism; NF-kappa B p50 Subunit - metabolism; Severity of Illness Index; Signaling; Survival; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha - metabolism; nuclear factor κB; IBD; 2,4-dinitro-1-fluorobenzene; ENS; TNF; IFN; NF-κB; analysis of variance; ANOVA; glyceraldehyde-3-phosphate dehydrogenase; interleukin; WT; polymerase chain reaction; IL; DSS; DNFB; dextran sulfate sodium; interferon; TNBS; trinitrobenzene sulfonic acid; Signaling; delayed-type hypersensitivity; Crohn's Disease; tumor necrosis factor; enzyme-linked immunosorbent assay; DTH; Colitis; enteric nervous system; wild-type; GAPDH; PCR; ELISA

Background & Aims Enteric neurons have been reported to be increased in inflamed regions of the bowel in patients with inflammatory bowel disease or intestinal neurogangliomatosis. It is impossible to determine whether this hyperinnervation predates intestinal inflammation, results from it, or c...