Human norovirus targets enteroendocrine epithelial cells in the small intestine

• Published in: Nature communications Vol. 11; no. 1; pp. 2759 - 10
• Main Authors: Green, Kim Y., Kaufman, Stuart S., Nagata, Bianca M., Chaimongkol, Natthawan, Kim, Daniel Y., Levenson, Eric A., Tin, Christine M., Yardley, Allison Behrle, Johnson, Jordan A., Barletta, Ana Beatriz F., Khan, Khalid M., Yazigi, Nada A., Subramanian, Sukanya, Moturi, Sangeetha R., Fishbein, Thomas M., Moore, Ian N., Sosnovtsev, Stanislav V.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.06.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 14; 14/1; 14/32; 45; 45/23; 45/88; 45/90; 631/326/596/2555; 692/4020/1503/1501; 82/1; 82/51; Animal diseases; Animal health; Animal models; Antigens; Diarrhea; Epithelial cells; Gastroenteritis; Humanities and Social Sciences; Immunocompromised hosts; Intestine; multidisciplinary; Norovirus; Pathogenesis; Patients; Pediatrics; Replication; Ribonucleic acid; RNA; Science; Science (multidisciplinary); Small intestine; Systems analysis; Tropism; Vaccines

Human noroviruses are a major cause of diarrheal illness, but pathogenesis is poorly understood. Here, we investigate the cellular tropism of norovirus in specimens from four immunocompromised patients. Abundant norovirus antigen and RNA are detected throughout the small intestinal tract in jejunal...