Metformin ameliorates polycystic ovary syndrome in a rat model by decreasing excessive autophagy in ovarian granulosa cells via the PI3K/AKT/mTOR pathway

• Published in: Endocrine Journal Vol. 69; no. 7; pp. 863 - 875
• Main Authors: Xu, Bo, Dai, Wenjie, Liu, Ling, Han, Hang, Zhang, Jingjing, Du, Xing, Pei, Xiuying, Fu, Xufeng
• Format: Journal Article
• Language: English
• Published: Japan The Japan Endocrine Society 01.01.2022; Japan Science and Technology Agency
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Autophagy; Excessive autophagy; Granulosa cells; Hydrogen peroxide; Infertility; Metformin; Ovarian granulosa cells; Ovaries; Ovulation; Oxidative stress; PI3K/AKT/mTOR; Polycystic ovary syndrome; Signal transduction; TOR protein; Polycystic ovary syndrome; Ovarian granulosa cells; Excessive autophagy; PI3K/AKT/mTOR; Metformin

Polycystic ovary syndrome (PCOS) is a common gynecological disease accompanied by a variety of clinical features, including anovulation, hyperandrogenism, and ovarian abnormalities, resulting in infertility. PCOS affects approximately 6%–15% of all reproductive-age women worldwide. Metformin, a popu...