Comparison of HIV incidence estimated in clinical trial and observational cohort settings in a high risk fishing population in Uganda: Implications for sample size estimates

• Published in: Vaccine Vol. 34; no. 15; pp. 1778 - 1785
• Main Authors: Abaasa, Andrew, Asiki, Gershim, Price, Matthew A, Ruzagira, Eugene, Kibengo, Freddie, Bahemuka, Ubaldo, Fast, Patricia E, Kamali, Anatoli
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 04.04.2016; Elsevier Limited
• Subjects: Acquired immune deficiency syndrome; Adolescent; Adult; AIDS; Alcohol; Allergy and Immunology; Condoms; Demographics; Estimate; Estimates; Feasibility studies; Female; Fish populations; Fishing; Fishing communities; Health risks; Hepatitis B virus; HIV; HIV Infections - epidemiology; Human immunodeficiency virus; Humans; Implications; Incidence; Lentivirus; Male; Middle Aged; Observational studies; Patient Selection; Prospective Studies; Public health; Retention; Retroviridae; Risk Assessment; Risk taking; Sample; Sample Size; Sexually transmitted diseases; Size; STD; Syphilis; Uganda - epidemiology; Vaccines; Volunteers; Young Adult; Uganda; Estimate; HIV; Sample; Size; Vaccines; Incidence; Implications

Abstract Background Clinical trial participants may differ from the source population due to the demands of trial participation and self-selection, inadvertent selection of a lower-risk group, or both. We investigated the HIV risk status of volunteers in a Simulated Vaccine Efficacy Trial (SiVET) ne...