Bitter taste receptor T2R38 is expressed on skin-infiltrating lymphocytes and regulates lymphocyte migration

• Published in: Scientific reports Vol. 12; no. 1; pp. 11790 - 10
• Main Authors: Sakakibara, Moe, Sumida, Hayakazu, Yanagida, Keisuke, Miyasato, Sosuke, Nakamura, Motonao, Sato, Shinichi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.07.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/1619; 631/250/98; 631/80/84; 692/699/4033; Atopic dermatitis; Bitter taste; CCL17 protein; CD3 antigen; Chemokines; Dermatitis; Dermis; Eczema; Epidermis; Flow cytometry; G protein-coupled receptors; Gene expression; Humanities and Social Sciences; Immunoglobulin E; Keratinocytes; Leukemia; Leukocyte migration; Lymphocytes; Lymphocytes T; Migration inhibition; multidisciplinary; Oral cavity; Science; Science (multidisciplinary); Skin diseases; Taste; Taste receptors; Therapeutic targets; Thymus

Bitter taste receptors (T2Rs) are G protein-coupled receptors involved in the perception of bitter taste on the tongue. In humans, T2Rs have been found in several sites outside the oral cavity. Although T2R38 has been reported to be expressed on peripheral lymphocytes, it is poorly understood whethe...