genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease - Tuncman, G; Erbay, E; Hom, X; De Vivo, I; Campos, H; Rimm, E.B; Hotamisligil, G.S (Proceedings of the National Academy of Sciences - PNAS, 2006)
Keywords: Adipose tissue; Adipose Tissue - physiology; Adipose tissues; Adult; Alleles; Animals; aP2 gene; aP2 locus; Base Sequence; binding capacity; Biological Sciences; Cardiovascular diseases; Cardiovascular Diseases - genetics; CCAAT-Enhancer-Binding Protein-alpha - metabolism; Cellular biology; Cohort Studies; Diabetes Mellitus, Type 2 - genetics; DNA; fatty acid-binding proteins; Fatty Acid-Binding Proteins - chemistry; Fatty Acid-Binding Proteins - genetics; Fatty Acid-Binding Proteins - metabolism; Fatty acids; Female; gene expression; gene frequency; genes; Genetic diversity; Genetic factors; Genetic Predisposition to Disease; Genetic variance; genetic variation; Genotype; Genotype & phenotype; Human genetics; Humans; hypertriglyceridemia; Hypertriglyceridemia - genetics; Lipid metabolism; loci; Medical genetics; Metabolic diseases; Metabolic syndrome; Middle Aged; Molecular Sequence Data; noninsulin-dependent diabetes mellitus; Obesity; Obesity - complications; Obesity - epidemiology; Obesity - genetics; Odds Ratio; Phenotype; Polymorphism, Genetic; Population genetics; Population studies; Promoter regions; Promoter Regions, Genetic; Prospective Studies; Protein Binding; Protein Isoforms - genetics; Protein Isoforms - metabolism; Proteins; single nucleotide polymorphism; transcription factors; Transcription, Genetic; Triglycerides - blood; Type 2 diabetes mellitus