Efficacy of Nirmatrelvir/ritonavir in reducing the risk of severe outcome in patients with SARS-CoV-2 infection: a real-life full-matched case-control study (SAVALO Study)

• Published in: BMC infectious diseases Vol. 24; no. 1; pp. 1434 - 9
• Main Authors: Gentile, Ivan, Giaccone, Agnese, Scirocco, Maria Michela, Di Brizzi, Francesco, Cuccurullo, Federica, Silvitelli, Maria, Ametrano, Luigi, Alfè, Francesco Antimo, Pietroluongo, Daria, Irace, Irene, Chiariello, Mariarosaria, De Felice, Noemi, Severino, Simone, Viceconte, Giulio, Schiano Moriello, Nicola, Maraolo, Alberto Enrico, Buonomo, Antonio Riccardo, Scotto, Riccardo, Borrelli, Anna, Calabria, Ferdinando, Castaldo, Giuseppe, Cattaneo, Letizia, Chiariello, Maria Rosaria, Cotugno, Mariarosaria, d’Agostino, Alessia, Diana, Dario, Di Filippo, Giovanni, Di Filippo, Isabella, Di Fusco, Antonio, Di Panni, Federico, Di Troia, Gaia, Esposito, Nunzia, Faiella, Mariarosaria, Festa, Lidia, Foggia, Maria, Forte, Maria Elisabetta, Fusco, Ludovica, Gallicchio, Antonella, Gargiulo, Gianpaolo, Gesmundo, Antonia, Iervolino, Carmela, Iuliano, Antonio, Licciardi, Federica, Longo, Giuseppe, Lorito, Matteo, Mercinelli, Simona, Minervini, Fulvio, Muto, Giuseppina, Nobile, Mariano, Pinchera, Biagio, Portella, Giuseppe, Reynaud, Laura, Sardanelli, Alessia, Sarno, Marina, Scordino, Fabrizio, Susini, Stefano Mario, Tanzillo, Anastasia, Tosone, Grazia, Trucillo, Emilia, Vecchietti, Ilaria, Zappulo, Emanuela, Zumbo, Giulia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.12.2024; BioMed Central; BMC
• Subjects: Adult; Aged; Antiretroviral drugs; Antiviral Agents - therapeutic use; Antiviral drugs; Cardiovascular disease; Case studies; Case-Control Studies; Chronic obstructive pulmonary disease; Comorbidity; COVID-19; COVID-19 - epidemiology; COVID-19 - mortality; COVID-19 Drug Treatment; COVID-19 vaccines; Diabetes; Disease transmission; Dosage and administration; Drug Combinations; Drug therapy, Combination; Early treatment; Effectiveness; Female; Health services; HIV; Hospitalization - statistics & numerical data; Hospitals; Human immunodeficiency virus; Humans; Hypertension; Immune system; Immunity (Disease); Infectious diseases; Italy - epidemiology; Kidney diseases; Lopinavir - therapeutic use; Lung diseases; Male; Middle Aged; Monoclonal antibodies; Mortality; Nirmatrelvir/ritonavir; Patient outcomes; Patients; Performance evaluation; Public health; Ritonavir; Ritonavir - therapeutic use; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Treatment Outcome; Tumor necrosis factor-TNF; Vaccination; Variables; Viral diseases; Italy; COVID-19; SARS-CoV-2; Nirmatrelvir/ritonavir; Early treatment; Mortality

Ritonavir-boosted nirmatrelvir (N/r) is an antiviral which targets the main viral protease, administered to prevent the progression of SARS-CoV-2 infection in patients at high risk for severe COVID-19. We present a real-life case-control study evaluating the efficacy of N/r therapy in SARS-CoV-2 omi...