High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice

• Published in: Stem cell research Vol. 14; no. 3; pp. 307 - 322
• Main Authors: Rao, Tata Nageswara, Marks-Bluth, Jonathan, Sullivan, Jessica, Gupta, Manoj K., Chandrakanthan, Vashe, Fitch, Simon R., Ottersbach, Katrin, Jang, Young C., Piao, Xianhua, Kulkarni, Rohit N., Serwold, Thomas, Pimanda, John E., Wagers, Amy J.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.05.2015; Elsevier
• Subjects: Animals; Cell Proliferation; Flow Cytometry; Gene Expression Profiling; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Hematopoietic Stem Cells - physiology; Mice; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Receptors, G-Protein-Coupled - physiology; BFFP; GPR56; GPCRs; BMT; HSPCs; HSCs; G-CSF; 5-FU

Blood formation by hematopoietic stem cells (HSCs) is regulated by a still incompletely defined network of general and HSC-specific regulators. In this study, we analyzed the role of G-protein coupled receptor 56 (Gpr56) as a candidate HSC regulator based on its differential expression in quiescent...