JC polyomavirus reactivation is common following allogeneic stem cell transplantation and its preemptive detection may prevent lethal complications

• Published in: Bone marrow transplantation (Basingstoke) Vol. 50; no. 7; pp. 984 - 991
• Main Authors: Wittmann, T, Horowitz, N, Benyamini, N, Henig, I, Zuckerman, T, Rowe, J M, Kra-Oz, Z, Szwarcwort Cohen, M, Oren, I, Avivi, I
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2015; Nature Publishing Group
• Subjects: 38/77; 692/499; 692/700/565/2319; Adolescent; Adult; Aged; Bone marrow; Cell Biology; Complications; Conditioning; Cytomegalovirus; Cytomegalovirus infections; Deoxyribonucleic acid; DNA; Encephalitis; Female; Hematology; Hematopoietic Stem Cell Transplantation - adverse effects; Hematopoietic Stem Cell Transplantation - methods; Humans; Immunosuppression; Immunosuppressive agents; Internal Medicine; JC Virus - pathogenicity; Leukoencephalopathy; Leukoencephalopathy, Progressive Multifocal - virology; Male; Medicine; Medicine & Public Health; Middle Aged; Multivariate analysis; original-article; Patient outcomes; Polyomavirus; Preempting; Progressive multifocal leukoencephalopathy; Public Health; Risk analysis; Risk factors; Stem cell transplantation; Stem Cells; Transplantation; Transplantation, Homologous - adverse effects; Transplantation, Homologous - methods; Viral infections; Young Adult; Israel

Extended application of allogeneic stem cell transplantation (alloSCT) is expected to increase the frequency of JC polyomavirus (JCPyV)-related progressive multifocal leukoencephalopathy (PML). The aim of this study was to assess frequency, risk factors and course of JCPyV reactivation in allografte...