Human adenovirus type 4 (HAdV-4) associated acute respiratory tract infection in children & genetic characteristics of HAdV-4 in China: a prospective multicenter study

• Published in: BMC infectious diseases Vol. 24; no. 1; pp. 936 - 13
• Main Authors: Wang, Jinjin, Feng, Qianyu, Duan, Yali, Ai, Junhong, Zhu, Yun, Wang, Ran, Chen, Xiangpeng, Lu, Gen, Sun, Yun, Li, Changchong, Jin, Rong, Shang, Yunxiao, Xu, Baoping, Xie, Zhengde
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.09.2024; BioMed Central; BMC
• Subjects: Acute respiratory infection; Adenovirus Infections, Human - epidemiology; Adenovirus Infections, Human - virology; Adenoviruses; Adenoviruses, Human - classification; Adenoviruses, Human - genetics; Adenoviruses, Human - isolation & purification; Amino acids; Antigens; Bioinformatics; Capsid Proteins - genetics; Causes of; Child; Child, Preschool; Children; China - epidemiology; Clinical characteristics; Conjunctivitis; Cough; Development and progression; Drug development; Epidemiology; Female; Gene sequencing; Genes; Genetic aspects; Genetic characteristics; Genomes; Genomic analysis; Genomics; Hemophagocytic syndrome; Hospitalization; Human adenovirus type 4; Humans; Identification and classification; Infant; Infections; Influenza; Laboratories; Lung diseases; Male; Medical research; Medicine, Experimental; Pediatric intensive care; Pediatric research; Pediatric respiratory diseases; Pediatrics; Phylogeny; Pneumonia; Polymerase chain reaction; Prevalence; Prospective Studies; Proteins; Prototypes; R&D; Recombination; Research & development; Respiratory tract; Respiratory tract diseases; Respiratory tract infection; Respiratory Tract Infections - epidemiology; Respiratory Tract Infections - virology; Strain analysis; Vaccines; Viral proteins; Viruses; Vision disorders in children; China; Beijing China; Singapore; United States > US; Germany; Clinical characteristics; Genetic characteristics; Acute respiratory infection; Children; Human adenovirus type 4

Human adenovirus (HAdV) is an important pathogen causing acute respiratory infection (ARI) in children. Many countries, including China, have experienced sporadic or outbreaks related to HAdV-4, and death cases were reported. However, there is little research on HAdV-4 and the epidemic situation of...