Detection of Circulating Tumor DNA in Plasma: A Potential Biomarker for Esophageal Adenocarcinoma

• Published in: The Annals of thoracic surgery Vol. 108; no. 2; pp. 343 - 349
• Main Authors: Egyud, Matthew, Tejani, Mohamedtaki, Pennathur, Arjun, Luketich, James, Sridhar, Praveen, Yamada, Emiko, Ståhlberg, Anders, Filges, Stefan, Krzyzanowski, Paul, Jackson, Jennifer, Kalatskaya, Irina, Jiao, Wei, Nielsen, Gradon, Zhou, Zhongren, Litle, Virginia, Stein, Lincoln, Godfrey, Tony
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.08.2019
• Subjects: Adenocarcinoma - blood; Adenocarcinoma - diagnosis; Adenocarcinoma - genetics; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; cancer; Cancer and Oncology; Cancer och onkologi; Cardiovascular System & Cardiology; Circulating Tumor DNA - blood; Circulating Tumor DNA - genetics; diagnosis; Disease Progression; DNA, Neoplasm - genetics; epidemiology; Esophageal Neoplasms - blood; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - genetics; exome; Female; Humans; Liquid Biopsy; Male; monitor; Mutation; mutations; Neoplasm Staging - methods; patterns; recurrence; Respiratory System; Surgery; survival; CTR; ypTNM; POD; EAC; PET-CT; SiMSen-Seq; ARID1A; bp; ctDNA; CT; Debarcer; ERBB4; FFPE; pTNM; IGV; NGS; XRT; TP53; cTNM; PCR

Recent literature has demonstrated the potential of “liquid biopsy” and detection of circulating tumor (ct)DNA as a cancer biomarker. However, to date there is a lack of data specific to esophageal adenocarcinoma (EAC). This study was conducted to determine how detection and quantification of ctDNA...