Detection of Circulating Tumor DNA in Plasma: A Potential Biomarker for Esophageal Adenocarcinoma

Recent literature has demonstrated the potential of “liquid biopsy” and detection of circulating tumor (ct)DNA as a cancer biomarker. However, to date there is a lack of data specific to esophageal adenocarcinoma (EAC). This study was conducted to determine how detection and quantification of ctDNA...

Full description

Saved in:
Bibliographic Details
Published inThe Annals of thoracic surgery Vol. 108; no. 2; pp. 343 - 349
Main Authors Egyud, Matthew, Tejani, Mohamedtaki, Pennathur, Arjun, Luketich, James, Sridhar, Praveen, Yamada, Emiko, Ståhlberg, Anders, Filges, Stefan, Krzyzanowski, Paul, Jackson, Jennifer, Kalatskaya, Irina, Jiao, Wei, Nielsen, Gradon, Zhou, Zhongren, Litle, Virginia, Stein, Lincoln, Godfrey, Tony
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.08.2019
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Recent literature has demonstrated the potential of “liquid biopsy” and detection of circulating tumor (ct)DNA as a cancer biomarker. However, to date there is a lack of data specific to esophageal adenocarcinoma (EAC). This study was conducted to determine how detection and quantification of ctDNA changes with disease burden in patients with EAC and evaluate its potential as a biomarker in this population. Blood samples were obtained from patients with stage I to IV EAC. Longitudinal blood samples were collected from a subset of patients. Imaging studies and pathology reports were reviewed to determine disease course. Tumor samples were sequenced to identify mutations. Mutations in plasma DNA were detected using custom, barcoded, patient-specific sequencing libraries. Mutations in plasma were quantified, and associations with disease stage and response to therapy were explored. Plasma samples from a final cohort of 38 patients were evaluated. Baseline plasma samples were ctDNA positive for 18 patients (47%) overall, with tumor allele frequencies ranging from 0.05% to 5.30%. Detection frequency of ctDNA and quantity of ctDNA increased with stage. Data from longitudinal samples indicate that ctDNA levels correlate with and precede evidence of response to therapy or recurrence. ctDNA can be detected in plasma of EAC patients and correlates with disease burden. Detection of ctDNA in early-stage EAC is challenging and may limit diagnostic applications. However, our data demonstrate the potential of ctDNA as a dynamic biomarker to monitor treatment response and disease recurrence in patients with EAC.
AbstractList BACKGROUNDRecent literature has demonstrated the potential of "liquid biopsy" and detection of circulating tumor (ct)DNA as a cancer biomarker. However, to date there is a lack of data specific to esophageal adenocarcinoma (EAC). This study was conducted to determine how detection and quantification of ctDNA changes with disease burden in patients with EAC and evaluate its potential as a biomarker in this population. METHODSBlood samples were obtained from patients with stage I to IV EAC. Longitudinal blood samples were collected from a subset of patients. Imaging studies and pathology reports were reviewed to determine disease course. Tumor samples were sequenced to identify mutations. Mutations in plasma DNA were detected using custom, barcoded, patient-specific sequencing libraries. Mutations in plasma were quantified, and associations with disease stage and response to therapy were explored. RESULTSPlasma samples from a final cohort of 38 patients were evaluated. Baseline plasma samples were ctDNA positive for 18 patients (47%) overall, with tumor allele frequencies ranging from 0.05% to 5.30%. Detection frequency of ctDNA and quantity of ctDNA increased with stage. Data from longitudinal samples indicate that ctDNA levels correlate with and precede evidence of response to therapy or recurrence. CONCLUSIONSctDNA can be detected in plasma of EAC patients and correlates with disease burden. Detection of ctDNA in early-stage EAC is challenging and may limit diagnostic applications. However, our data demonstrate the potential of ctDNA as a dynamic biomarker to monitor treatment response and disease recurrence in patients with EAC.
Recent literature has demonstrated the potential of “liquid biopsy” and detection of circulating tumor (ct)DNA as a cancer biomarker. However, to date there is a lack of data specific to esophageal adenocarcinoma (EAC). This study was conducted to determine how detection and quantification of ctDNA changes with disease burden in patients with EAC and evaluate its potential as a biomarker in this population. Blood samples were obtained from patients with stage I to IV EAC. Longitudinal blood samples were collected from a subset of patients. Imaging studies and pathology reports were reviewed to determine disease course. Tumor samples were sequenced to identify mutations. Mutations in plasma DNA were detected using custom, barcoded, patient-specific sequencing libraries. Mutations in plasma were quantified, and associations with disease stage and response to therapy were explored. Plasma samples from a final cohort of 38 patients were evaluated. Baseline plasma samples were ctDNA positive for 18 patients (47%) overall, with tumor allele frequencies ranging from 0.05% to 5.30%. Detection frequency of ctDNA and quantity of ctDNA increased with stage. Data from longitudinal samples indicate that ctDNA levels correlate with and precede evidence of response to therapy or recurrence. ctDNA can be detected in plasma of EAC patients and correlates with disease burden. Detection of ctDNA in early-stage EAC is challenging and may limit diagnostic applications. However, our data demonstrate the potential of ctDNA as a dynamic biomarker to monitor treatment response and disease recurrence in patients with EAC.
Background. Recent literature has demonstrated the potential of "liquid biopsy" and detection of circulating tumor (ct)DNA as a cancer biomarker. However, to date there is a lack of data specific to esophageal adenocarcinoma (EAC). This study was conducted to determine how detection and quantification of ctDNA changes with disease burden in patients with EAC and evaluate its potential as a biomarker in this population. Methods. Blood samples were obtained from patients with stage I to IV EAC. Longitudinal blood samples were collected from a subset of patients. Imaging studies and pathology reports were reviewed to determine disease course. Tumor samples were sequenced to identify mutations. Mutations in plasma DNA were detected using custom, barcoded, patient-specific sequencing libraries. Mutations in plasma were quantified, and associations with disease stage and response to therapy were explored. Results. Plasma samples from a final cohort of 38 patients were evaluated. Baseline plasma samples were ctDNA positive for 18 patients (47%) overall, with tumor allele frequencies ranging from 0.05% to 5.30%. Detection frequency of ctDNA and quantity of ctDNA increased with stage. Data from longitudinal samples indicate that ctDNA levels correlate with and precede evidence of response to therapy or recurrence. Conclusions. ctDNA can be detected in plasma of EAC patients and correlates with disease burden. Detection of ctDNA in early-stage EAC is challenging and may limit diagnostic applications. However, our data demonstrate the potential of ctDNA as a dynamic biomarker to monitor treatment response and disease recurrence in patients with EAC. (C) 2019 by The Society of Thoracic Surgeons
Author Litle, Virginia
Tejani, Mohamedtaki
Stein, Lincoln
Pennathur, Arjun
Luketich, James
Ståhlberg, Anders
Jackson, Jennifer
Zhou, Zhongren
Godfrey, Tony
Filges, Stefan
Nielsen, Gradon
Yamada, Emiko
Krzyzanowski, Paul
Sridhar, Praveen
Kalatskaya, Irina
Egyud, Matthew
Jiao, Wei
AuthorAffiliation 1) Boston University/Boston Medical Center, Department of Surgery
2) Sahlgrenska Cancer Center, University of Gothenburg
6) University of Rochester Department of Pathology
3) Ontario Institute for Cancer Research, Toronto
5) University of Pittsburgh, Department of Surgery
4) University of Rochester Department of Medicine
AuthorAffiliation_xml – name: 2) Sahlgrenska Cancer Center, University of Gothenburg
– name: 1) Boston University/Boston Medical Center, Department of Surgery
– name: 3) Ontario Institute for Cancer Research, Toronto
– name: 4) University of Rochester Department of Medicine
– name: 5) University of Pittsburgh, Department of Surgery
– name: 6) University of Rochester Department of Pathology
Author_xml – sequence: 1
  givenname: Matthew
  surname: Egyud
  fullname: Egyud, Matthew
  organization: Department of Surgery, Boston University/Boston Medical Center, Boston, Massachusetts
– sequence: 2
  givenname: Mohamedtaki
  surname: Tejani
  fullname: Tejani, Mohamedtaki
  organization: Department of Medicine, University of Rochester, Rochester, New York
– sequence: 3
  givenname: Arjun
  surname: Pennathur
  fullname: Pennathur, Arjun
  organization: Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania
– sequence: 4
  givenname: James
  surname: Luketich
  fullname: Luketich, James
  organization: Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania
– sequence: 5
  givenname: Praveen
  surname: Sridhar
  fullname: Sridhar, Praveen
  organization: Department of Surgery, Boston University/Boston Medical Center, Boston, Massachusetts
– sequence: 6
  givenname: Emiko
  surname: Yamada
  fullname: Yamada, Emiko
  organization: Department of Surgery, Boston University/Boston Medical Center, Boston, Massachusetts
– sequence: 7
  givenname: Anders
  surname: Ståhlberg
  fullname: Ståhlberg, Anders
  organization: Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden
– sequence: 8
  givenname: Stefan
  surname: Filges
  fullname: Filges, Stefan
  organization: Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden
– sequence: 9
  givenname: Paul
  surname: Krzyzanowski
  fullname: Krzyzanowski, Paul
  organization: Ontario Institute for Cancer Research, Toronto, Ontario, Canada
– sequence: 10
  givenname: Jennifer
  surname: Jackson
  fullname: Jackson, Jennifer
  organization: Department of Surgery, Boston University/Boston Medical Center, Boston, Massachusetts
– sequence: 11
  givenname: Irina
  surname: Kalatskaya
  fullname: Kalatskaya, Irina
  organization: Ontario Institute for Cancer Research, Toronto, Ontario, Canada
– sequence: 12
  givenname: Wei
  surname: Jiao
  fullname: Jiao, Wei
  organization: Ontario Institute for Cancer Research, Toronto, Ontario, Canada
– sequence: 13
  givenname: Gradon
  surname: Nielsen
  fullname: Nielsen, Gradon
  organization: Department of Medicine, University of Rochester, Rochester, New York
– sequence: 14
  givenname: Zhongren
  surname: Zhou
  fullname: Zhou, Zhongren
  organization: Department of Pathology, University of Rochester, Rochester, New York
– sequence: 15
  givenname: Virginia
  surname: Litle
  fullname: Litle, Virginia
  organization: Department of Surgery, Boston University/Boston Medical Center, Boston, Massachusetts
– sequence: 16
  givenname: Lincoln
  surname: Stein
  fullname: Stein, Lincoln
  organization: Ontario Institute for Cancer Research, Toronto, Ontario, Canada
– sequence: 17
  givenname: Tony
  surname: Godfrey
  fullname: Godfrey, Tony
  email: godfreyt@bu.edu
  organization: Department of Surgery, Boston University/Boston Medical Center, Boston, Massachusetts
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31059681$$D View this record in MEDLINE/PubMed
https://gup.ub.gu.se/publication/282591$$DView record from Swedish Publication Index
BookMark eNqFkU9v1DAQxS1URLeFr4B85JLgP4njcEDabltAqtoeytmynUnWS2IvdlLEt6-rLYWeOFn2-72Z8bwTdOSDB4QwJSUlVHzclXrehqhtWmLJCG1LUpWEVK_QitY1KwSr2yO0IoTwomqb-hidpLTLV5blN-iYU1K3QtIV0ucwg51d8Dj0eOOiXUY9Oz_gu2UKEZ9fr7Hz-HbUadKf8Brfhhn87PSIz1yYdPwBEfcZvEhhv9UDZGHdgQ9WR-t8Jt6i170eE7x7Ok_R98uLu83X4urmy7fN-qqwteRzwSpipGwbI7Tsu55T1pq-04waU-vOmLYz1DDT9BI6IoUQFmrS1pZpaireCH6KikPd9Av2i1H76PJ4v1XQTg3LXuWnYVEJFJN5OzTznw98hifobP5V1OML20vFu60awr0SohGMVrnAh6cCMfxcIM1qcsnCOGoPYUmKMc4oJ7yRGZUH1MaQUoT-uQ0l6jFRtVN_E1WPiSpSqZxotr7_d8xn458IM3B2ACAv995BVMk68BY6F3Oyqgvu_10eAE2mu-w
CitedBy_id crossref_primary_10_1016_j_suc_2019_02_010
crossref_primary_10_1016_j_suc_2021_03_011
crossref_primary_10_1245_s10434_020_09285_w
crossref_primary_10_1007_s10120_022_01313_w
crossref_primary_10_7717_peerj_16802
crossref_primary_10_1038_s41416_023_02458_w
crossref_primary_10_3390_jcm10010117
crossref_primary_10_1002_path_6016
crossref_primary_10_1016_j_tranon_2023_101716
crossref_primary_10_1097_SLA_0000000000005177
crossref_primary_10_1245_s10434_020_09219_6
crossref_primary_10_1002_ags3_12350
crossref_primary_10_3390_ijms24043316
crossref_primary_10_1200_PO_22_00420
crossref_primary_10_1080_14656566_2022_2140585
crossref_primary_10_3390_cancers14040996
crossref_primary_10_1183_13993003_02682_2020
crossref_primary_10_3390_curroncol29030120
crossref_primary_10_1080_07357907_2024_2316297
crossref_primary_10_1371_journal_pone_0245488
crossref_primary_10_3390_ijms241310673
crossref_primary_10_1002_cac2_12118
crossref_primary_10_3389_fimmu_2023_1330928
crossref_primary_10_1038_s41467_024_46307_7
crossref_primary_10_3390_cancers14184417
crossref_primary_10_1093_bib_bbac248
crossref_primary_10_1016_j_ctrv_2023_102595
crossref_primary_10_3390_genes12030349
crossref_primary_10_1016_j_cancergen_2021_08_005
crossref_primary_10_1245_s10434_023_13194_z
crossref_primary_10_17925_OHR_2022_18_2_107
Cites_doi 10.1016/j.trsl.2017.09.004
10.1016/j.jmoldx.2015.10.004
10.18632/oncotarget.11409
10.1093/bioinformatics/bts271
10.1097/JTO.0b013e3182397751
10.1371/journal.pone.0023418
10.1097/01.JTO.0000437420.38972.fb
10.1038/nm.1789
10.1038/nprot.2017.006
10.1093/nar/gkw224
10.1186/s40425-014-0042-0
10.1038/ng.3343
10.1056/NEJMoa1213261
10.1016/j.jamcollsurg.2010.01.006
10.1038/nbt.2514
10.1126/scitranslmed.3007094
10.1016/j.semradonc.2015.05.001
10.1053/j.gastro.2015.04.053
10.1016/j.bbrc.2016.02.011
10.1016/j.jamcollsurg.2005.12.022
10.1093/annonc/mdv177
10.1586/14737159.2015.1019476
10.1016/j.ejca.2014.08.020
10.1056/NEJMoa1112088
10.1093/jnci/dji024
10.1002/bjs5.30
10.1111/j.1365-2036.2006.02782.x
10.1038/ng.2591
10.1111/dote.12147
ContentType Journal Article
Copyright 2019 The Society of Thoracic Surgeons
Copyright © 2019 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
Copyright_xml – notice: 2019 The Society of Thoracic Surgeons
– notice: Copyright © 2019 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
5PM
ADTPV
AOWAS
F1U
DOI 10.1016/j.athoracsur.2019.04.004
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
SwePub
SwePub Articles
SWEPUB Göteborgs universitet
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

MEDLINE

Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 1552-6259
EndPage 349
ExternalDocumentID oai_gup_ub_gu_se_282591
10_1016_j_athoracsur_2019_04_004
31059681
S0003497519306101
Genre Multicenter Study
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NCI NIH HHS
  grantid: R01 CA208599
– fundername: NCI NIH HHS
  grantid: R21 CA172999
GroupedDBID ---
--K
.1-
.55
.FO
.GJ
0R~
1B1
1P~
1~5
23M
3O-
4.4
457
4G.
53G
5GY
5RE
5VS
6J9
7-5
71M
AAEDT
AAEDW
AAEJM
AAIAV
AALRI
AAQFI
AAQQT
AAQXK
AAXUO
ABJNI
ABLJU
ABMAC
ABOCM
ACGFO
ACGFS
ACIUM
ACRZS
ADBBV
ADMUD
ADPAM
AENEX
AEVXI
AFCTW
AFFNX
AFRHN
AFTJW
AGHFR
AGZHU
AHPSJ
AI.
AITUG
AJJEV
AJUYK
ALMA_UNASSIGNED_HOLDINGS
ALXNB
AMRAJ
ASPBG
AVWKF
AZFZN
BAWUL
BELOY
C5W
CS3
DIK
E3Z
EBS
EFJIC
EJD
F5P
FDB
FEDTE
FGOYB
GBLVA
GX1
HVGLF
HZ~
IH2
IHE
J1W
J5H
K-O
KOM
L7B
M41
MO0
N9A
NQ-
O9-
OA-
OK1
OL.
OVD
P2P
P6G
PC.
R2-
RIG
ROL
RPZ
SES
SSZ
TEORI
TR2
UDS
UNMZH
UV1
VH1
W8F
X7M
XH2
XPP
Z5R
ZA5
ZGI
ZXP
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
ACRPL
ADNMO
CITATION
7X8
5PM
ADTPV
AOWAS
F1U
ID FETCH-LOGICAL-c583t-240b8897b6a8fdf3129bfda21bb5adbb9db1b2b7f8ed08666ce5095c2a1b43763
ISSN 0003-4975
IngestDate Sat Aug 24 00:19:34 EDT 2024
Tue Sep 17 21:06:19 EDT 2024
Fri Aug 16 21:06:08 EDT 2024
Fri Dec 06 01:13:26 EST 2024
Sat Sep 28 08:32:08 EDT 2024
Fri Feb 23 02:27:06 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords CTR
ypTNM
POD
EAC
PET-CT
SiMSen-Seq
ARID1A
bp
ctDNA
CT
Debarcer
ERBB4
FFPE
pTNM
IGV
NGS
XRT
TP53
cTNM
PCR
Language English
License Copyright © 2019 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c583t-240b8897b6a8fdf3129bfda21bb5adbb9db1b2b7f8ed08666ce5095c2a1b43763
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink http://www.annalsthoracicsurgery.org/article/S0003497519306101/pdf
PMID 31059681
PQID 2232130378
PQPubID 23479
PageCount 7
ParticipantIDs swepub_primary_oai_gup_ub_gu_se_282591
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6676214
proquest_miscellaneous_2232130378
crossref_primary_10_1016_j_athoracsur_2019_04_004
pubmed_primary_31059681
elsevier_sciencedirect_doi_10_1016_j_athoracsur_2019_04_004
PublicationCentury 2000
PublicationDate 2019-08-01
PublicationDateYYYYMMDD 2019-08-01
PublicationDate_xml – month: 08
  year: 2019
  text: 2019-08-01
  day: 01
PublicationDecade 2010
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle The Annals of thoracic surgery
PublicationTitleAlternate Ann Thorac Surg
PublicationYear 2019
Publisher Elsevier Inc
Publisher_xml – name: Elsevier Inc
References Saunders, Wong, Swamy, Becq, Murray, Cheetham (bib24) 2012; 28
Pohl, Welch (bib1) 2005; 97
Rubenstein, Shaheen (bib3) 2015; 149
Luo, Li, Hu (bib21) 2016; 471
Bratman, Newman, Alizadeh, Diehn (bib12) 2015; 15
Stahlberg, Krzyzanowski, Jackson, Egyud, Stein, Godfrey (bib16) 2016; 44
Tie, Kinde, Wang (bib18) 2015; 26
Cibulskis, Lawrence, Carter (bib23) 2013; 31
Knight, Zylstra, Van Hemelrijck (bib29) 2017; 1
Jackson, Choi, Luketich, Pennathur, Ståhlberg, Godfrey (bib25) 2016; 18
Lou, Sima, Adusumilli (bib10) 2013; 8
Schlansky, Dimarino, Loren, Infantolino, Kowalski, Cohen (bib5) 2006; 23
Stahlberg, Krzyzanowski, Egyud, Filges, Stein, Godfrey (bib15) 2017; 12
Mouliere, Robert, Arnau Peyrotte (bib26) 2011; 6
Lipson, Velculescu, Pritchard (bib17) 2014; 2
Dawson, Tsui, Murtaza (bib28) 2013; 368
Ueda, Iguchi, Masuda (bib20) 2016; 7
Portale, Hagen, Peters (bib4) 2006; 202
Abate, DeMeester, Zehetner (bib9) 2010; 210
Mathieu, Kanarek, Tsai, Rudin, Brock (bib2) 2014; 27
Dubecz, Gall, Solymosi (bib6) 2012; 7
Hölscher, Bollschweiler, Bogoevski, Schmidt, Semrau, Izbicki (bib7) 2014; 50
Chaudhuri, Binkley, Osmundson, Alizadeh, Diehn (bib13) 2015; 25
Dulak, Stojanov, Peng (bib22) 2013; 45
van Hagen, Hulshof, van Lanschot (bib8) 2012; 366
Bettegowda, Sausen, Leary (bib11) 2014; 6
Rumiato, Boldrin, Malacrida (bib19) 2017; 190
Stachler, Taylor-Weiner, Peng (bib27) 2015; 47
Diehl, Schmidt, Choti (bib14) 2008; 14
Lou (10.1016/j.athoracsur.2019.04.004_bib10) 2013; 8
Rubenstein (10.1016/j.athoracsur.2019.04.004_bib3) 2015; 149
Mathieu (10.1016/j.athoracsur.2019.04.004_bib2) 2014; 27
Jackson (10.1016/j.athoracsur.2019.04.004_bib25) 2016; 18
Hölscher (10.1016/j.athoracsur.2019.04.004_bib7) 2014; 50
Rumiato (10.1016/j.athoracsur.2019.04.004_bib19) 2017; 190
Dubecz (10.1016/j.athoracsur.2019.04.004_bib6) 2012; 7
Schlansky (10.1016/j.athoracsur.2019.04.004_bib5) 2006; 23
Stachler (10.1016/j.athoracsur.2019.04.004_bib27) 2015; 47
Ueda (10.1016/j.athoracsur.2019.04.004_bib20) 2016; 7
Stahlberg (10.1016/j.athoracsur.2019.04.004_bib15) 2017; 12
Bratman (10.1016/j.athoracsur.2019.04.004_bib12) 2015; 15
Dawson (10.1016/j.athoracsur.2019.04.004_bib28) 2013; 368
Luo (10.1016/j.athoracsur.2019.04.004_bib21) 2016; 471
Abate (10.1016/j.athoracsur.2019.04.004_bib9) 2010; 210
Saunders (10.1016/j.athoracsur.2019.04.004_bib24) 2012; 28
Stahlberg (10.1016/j.athoracsur.2019.04.004_bib16) 2016; 44
Diehl (10.1016/j.athoracsur.2019.04.004_bib14) 2008; 14
Tie (10.1016/j.athoracsur.2019.04.004_bib18) 2015; 26
Dulak (10.1016/j.athoracsur.2019.04.004_bib22) 2013; 45
van Hagen (10.1016/j.athoracsur.2019.04.004_bib8) 2012; 366
Bettegowda (10.1016/j.athoracsur.2019.04.004_bib11) 2014; 6
Cibulskis (10.1016/j.athoracsur.2019.04.004_bib23) 2013; 31
Pohl (10.1016/j.athoracsur.2019.04.004_bib1) 2005; 97
Mouliere (10.1016/j.athoracsur.2019.04.004_bib26) 2011; 6
Lipson (10.1016/j.athoracsur.2019.04.004_bib17) 2014; 2
Portale (10.1016/j.athoracsur.2019.04.004_bib4) 2006; 202
Knight (10.1016/j.athoracsur.2019.04.004_bib29) 2017; 1
Chaudhuri (10.1016/j.athoracsur.2019.04.004_bib13) 2015; 25
References_xml – volume: 23
  start-page: 587
  year: 2006
  end-page: 593
  ident: bib5
  article-title: A survey of oesophageal cancer: pathology, stage and clinical presentation
  publication-title: Aliment Pharmacol Ther
  contributor:
    fullname: Cohen
– volume: 18
  start-page: 235
  year: 2016
  end-page: 243
  ident: bib25
  article-title: Multiplex preamplification of serum DNA to facilitate reliable detection of extremely rare cancer mutations in circulating DNA by digital PCR
  publication-title: J Mol Diagn
  contributor:
    fullname: Godfrey
– volume: 45
  start-page: 478
  year: 2013
  end-page: 486
  ident: bib22
  article-title: Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
  publication-title: Nat Genet
  contributor:
    fullname: Peng
– volume: 1
  start-page: 182
  year: 2017
  end-page: 190
  ident: bib29
  article-title: Patterns of recurrence in oesophageal cancer following oesophagectomy in the era of neoadjuvant chemotherapy
  publication-title: BJS Open
  contributor:
    fullname: Van Hemelrijck
– volume: 6
  start-page: 224ra224
  year: 2014
  ident: bib11
  article-title: Detection of circulating tumor DNA in early-and late-stage human malignancies
  publication-title: Sci Transl Med
  contributor:
    fullname: Leary
– volume: 7
  start-page: 443
  year: 2012
  end-page: 447
  ident: bib6
  article-title: Temporal trends in long-term survival and cure rates in esophageal cancer: a SEER database analysis
  publication-title: J Thorac Oncol
  contributor:
    fullname: Solymosi
– volume: 15
  start-page: 715
  year: 2015
  end-page: 719
  ident: bib12
  article-title: Potential clinical utility of ultrasensitive circulating tumor DNA detection with CAPP-Seq
  publication-title: Expert Rev Mol Diag
  contributor:
    fullname: Diehn
– volume: 26
  start-page: 1715
  year: 2015
  end-page: 1722
  ident: bib18
  article-title: Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer
  publication-title: Ann Oncol
  contributor:
    fullname: Wang
– volume: 202
  start-page: 588
  year: 2006
  end-page: 596
  ident: bib4
  article-title: Modern 5-year survival of resectable esophageal adenocarcinoma: single institution experience with 263 patients
  publication-title: J Am Coll Surg
  contributor:
    fullname: Peters
– volume: 7
  start-page: 62280
  year: 2016
  end-page: 62291
  ident: bib20
  article-title: Somatic mutations in plasma cell-free DNA are diagnostic markers for esophageal squamous cell carcinoma recurrence
  publication-title: Oncotarget
  contributor:
    fullname: Masuda
– volume: 50
  start-page: 2950
  year: 2014
  end-page: 2957
  ident: bib7
  article-title: Prognostic impact of neoadjuvant chemoradiation in cT3 oesophageal cancer—a propensity score matched analysis
  publication-title: Eur J Cancer
  contributor:
    fullname: Izbicki
– volume: 97
  start-page: 142
  year: 2005
  end-page: 146
  ident: bib1
  article-title: The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence
  publication-title: J Natl Cancer Inst
  contributor:
    fullname: Welch
– volume: 44
  start-page: e105
  year: 2016
  ident: bib16
  article-title: Simple, multiplexed, PCR-based barcoding of DNA enables sensitive mutation detection in liquid biopsies using sequencing
  publication-title: Nucleic Acids Res
  contributor:
    fullname: Godfrey
– volume: 31
  start-page: 213
  year: 2013
  end-page: 219
  ident: bib23
  article-title: Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
  publication-title: Nat Biotechnol
  contributor:
    fullname: Carter
– volume: 14
  start-page: 985
  year: 2008
  end-page: 990
  ident: bib14
  article-title: Circulating mutant DNA to assess tumor dynamics
  publication-title: Nat Med
  contributor:
    fullname: Choti
– volume: 27
  start-page: 757
  year: 2014
  end-page: 763
  ident: bib2
  article-title: Age and sex differences in the incidence of esophageal adenocarcinoma: results from the Surveillance, Epidemiology, and End Results (SEER) registry (1973-2008)
  publication-title: Dis Esophagus
  contributor:
    fullname: Brock
– volume: 8
  start-page: 1558
  year: 2013
  end-page: 1562
  ident: bib10
  article-title: Esophageal cancer recurrence patterns and implications for surveillance
  publication-title: J Thorac Oncol
  contributor:
    fullname: Adusumilli
– volume: 2
  start-page: 42
  year: 2014
  ident: bib17
  article-title: Circulating tumor DNA analysis as a real-time method for monitoring tumor burden in melanoma patients undergoing treatment with immune checkpoint blockade
  publication-title: J Immunother Cancer
  contributor:
    fullname: Pritchard
– volume: 25
  start-page: 305
  year: 2015
  end-page: 312
  ident: bib13
  article-title: Predicting radiotherapy responses and treatment outcomes through analysis of circulating tumor DNA
  publication-title: Semin Radiat Oncol
  contributor:
    fullname: Diehn
– volume: 190
  start-page: 16
  year: 2017
  end-page: 24.e1
  ident: bib19
  article-title: Detection of genetic alterations in cfDNA as a possible strategy to monitor the neoplastic progression of Barrett’s esophagus
  publication-title: Transl Res
  contributor:
    fullname: Malacrida
– volume: 149
  start-page: 302
  year: 2015
  end-page: 317.e1
  ident: bib3
  article-title: Epidemiology, diagnosis, and management of esophageal adenocarcinoma
  publication-title: Gastroenterology
  contributor:
    fullname: Shaheen
– volume: 368
  start-page: 1199
  year: 2013
  end-page: 1209
  ident: bib28
  article-title: Analysis of circulating tumor DNA to monitor metastatic breast cancer
  publication-title: N Engl J Med
  contributor:
    fullname: Murtaza
– volume: 366
  start-page: 2074
  year: 2012
  end-page: 2084
  ident: bib8
  article-title: Preoperative chemoradiotherapy for esophageal or junctional cancer
  publication-title: N Engl J Med
  contributor:
    fullname: van Lanschot
– volume: 12
  start-page: 664
  year: 2017
  end-page: 682
  ident: bib15
  article-title: Simple multiplexed PCR-based barcoding of DNA for ultrasensitive mutation detection by next-generation sequencing
  publication-title: Nat Protoc
  contributor:
    fullname: Godfrey
– volume: 210
  start-page: 428
  year: 2010
  end-page: 435
  ident: bib9
  article-title: Recurrence after esophagectomy for adenocarcinoma: defining optimal follow-up intervals and testing
  publication-title: J Am Coll Surg
  contributor:
    fullname: Zehetner
– volume: 47
  start-page: 1047
  year: 2015
  end-page: 1055
  ident: bib27
  article-title: Paired exome analysis of Barrett’s esophagus and adenocarcinoma
  publication-title: Nat Genet
  contributor:
    fullname: Peng
– volume: 28
  start-page: 1811
  year: 2012
  end-page: 1817
  ident: bib24
  article-title: Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs
  publication-title: Bioinformatics
  contributor:
    fullname: Cheetham
– volume: 471
  start-page: 596
  year: 2016
  end-page: 602
  ident: bib21
  article-title: Noninvasive diagnosis and monitoring of mutations by deep sequencing of circulating tumor DNA in esophageal squamous cell carcinoma
  publication-title: Biochem Biophys Res Commun
  contributor:
    fullname: Hu
– volume: 6
  start-page: e23418
  year: 2011
  ident: bib26
  article-title: High fragmentation characterizes tumour-derived circulating DNA
  publication-title: PloS One
  contributor:
    fullname: Arnau Peyrotte
– volume: 190
  start-page: 16
  year: 2017
  ident: 10.1016/j.athoracsur.2019.04.004_bib19
  article-title: Detection of genetic alterations in cfDNA as a possible strategy to monitor the neoplastic progression of Barrett’s esophagus
  publication-title: Transl Res
  doi: 10.1016/j.trsl.2017.09.004
  contributor:
    fullname: Rumiato
– volume: 18
  start-page: 235
  year: 2016
  ident: 10.1016/j.athoracsur.2019.04.004_bib25
  article-title: Multiplex preamplification of serum DNA to facilitate reliable detection of extremely rare cancer mutations in circulating DNA by digital PCR
  publication-title: J Mol Diagn
  doi: 10.1016/j.jmoldx.2015.10.004
  contributor:
    fullname: Jackson
– volume: 7
  start-page: 62280
  year: 2016
  ident: 10.1016/j.athoracsur.2019.04.004_bib20
  article-title: Somatic mutations in plasma cell-free DNA are diagnostic markers for esophageal squamous cell carcinoma recurrence
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.11409
  contributor:
    fullname: Ueda
– volume: 28
  start-page: 1811
  year: 2012
  ident: 10.1016/j.athoracsur.2019.04.004_bib24
  article-title: Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts271
  contributor:
    fullname: Saunders
– volume: 7
  start-page: 443
  year: 2012
  ident: 10.1016/j.athoracsur.2019.04.004_bib6
  article-title: Temporal trends in long-term survival and cure rates in esophageal cancer: a SEER database analysis
  publication-title: J Thorac Oncol
  doi: 10.1097/JTO.0b013e3182397751
  contributor:
    fullname: Dubecz
– volume: 6
  start-page: e23418
  year: 2011
  ident: 10.1016/j.athoracsur.2019.04.004_bib26
  article-title: High fragmentation characterizes tumour-derived circulating DNA
  publication-title: PloS One
  doi: 10.1371/journal.pone.0023418
  contributor:
    fullname: Mouliere
– volume: 8
  start-page: 1558
  year: 2013
  ident: 10.1016/j.athoracsur.2019.04.004_bib10
  article-title: Esophageal cancer recurrence patterns and implications for surveillance
  publication-title: J Thorac Oncol
  doi: 10.1097/01.JTO.0000437420.38972.fb
  contributor:
    fullname: Lou
– volume: 14
  start-page: 985
  year: 2008
  ident: 10.1016/j.athoracsur.2019.04.004_bib14
  article-title: Circulating mutant DNA to assess tumor dynamics
  publication-title: Nat Med
  doi: 10.1038/nm.1789
  contributor:
    fullname: Diehl
– volume: 12
  start-page: 664
  year: 2017
  ident: 10.1016/j.athoracsur.2019.04.004_bib15
  article-title: Simple multiplexed PCR-based barcoding of DNA for ultrasensitive mutation detection by next-generation sequencing
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2017.006
  contributor:
    fullname: Stahlberg
– volume: 44
  start-page: e105
  year: 2016
  ident: 10.1016/j.athoracsur.2019.04.004_bib16
  article-title: Simple, multiplexed, PCR-based barcoding of DNA enables sensitive mutation detection in liquid biopsies using sequencing
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkw224
  contributor:
    fullname: Stahlberg
– volume: 2
  start-page: 42
  year: 2014
  ident: 10.1016/j.athoracsur.2019.04.004_bib17
  article-title: Circulating tumor DNA analysis as a real-time method for monitoring tumor burden in melanoma patients undergoing treatment with immune checkpoint blockade
  publication-title: J Immunother Cancer
  doi: 10.1186/s40425-014-0042-0
  contributor:
    fullname: Lipson
– volume: 47
  start-page: 1047
  year: 2015
  ident: 10.1016/j.athoracsur.2019.04.004_bib27
  article-title: Paired exome analysis of Barrett’s esophagus and adenocarcinoma
  publication-title: Nat Genet
  doi: 10.1038/ng.3343
  contributor:
    fullname: Stachler
– volume: 368
  start-page: 1199
  year: 2013
  ident: 10.1016/j.athoracsur.2019.04.004_bib28
  article-title: Analysis of circulating tumor DNA to monitor metastatic breast cancer
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1213261
  contributor:
    fullname: Dawson
– volume: 210
  start-page: 428
  year: 2010
  ident: 10.1016/j.athoracsur.2019.04.004_bib9
  article-title: Recurrence after esophagectomy for adenocarcinoma: defining optimal follow-up intervals and testing
  publication-title: J Am Coll Surg
  doi: 10.1016/j.jamcollsurg.2010.01.006
  contributor:
    fullname: Abate
– volume: 31
  start-page: 213
  year: 2013
  ident: 10.1016/j.athoracsur.2019.04.004_bib23
  article-title: Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.2514
  contributor:
    fullname: Cibulskis
– volume: 6
  start-page: 224ra224
  year: 2014
  ident: 10.1016/j.athoracsur.2019.04.004_bib11
  article-title: Detection of circulating tumor DNA in early-and late-stage human malignancies
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3007094
  contributor:
    fullname: Bettegowda
– volume: 25
  start-page: 305
  year: 2015
  ident: 10.1016/j.athoracsur.2019.04.004_bib13
  article-title: Predicting radiotherapy responses and treatment outcomes through analysis of circulating tumor DNA
  publication-title: Semin Radiat Oncol
  doi: 10.1016/j.semradonc.2015.05.001
  contributor:
    fullname: Chaudhuri
– volume: 149
  start-page: 302
  year: 2015
  ident: 10.1016/j.athoracsur.2019.04.004_bib3
  article-title: Epidemiology, diagnosis, and management of esophageal adenocarcinoma
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2015.04.053
  contributor:
    fullname: Rubenstein
– volume: 471
  start-page: 596
  year: 2016
  ident: 10.1016/j.athoracsur.2019.04.004_bib21
  article-title: Noninvasive diagnosis and monitoring of mutations by deep sequencing of circulating tumor DNA in esophageal squamous cell carcinoma
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2016.02.011
  contributor:
    fullname: Luo
– volume: 202
  start-page: 588
  year: 2006
  ident: 10.1016/j.athoracsur.2019.04.004_bib4
  article-title: Modern 5-year survival of resectable esophageal adenocarcinoma: single institution experience with 263 patients
  publication-title: J Am Coll Surg
  doi: 10.1016/j.jamcollsurg.2005.12.022
  contributor:
    fullname: Portale
– volume: 26
  start-page: 1715
  year: 2015
  ident: 10.1016/j.athoracsur.2019.04.004_bib18
  article-title: Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdv177
  contributor:
    fullname: Tie
– volume: 15
  start-page: 715
  year: 2015
  ident: 10.1016/j.athoracsur.2019.04.004_bib12
  article-title: Potential clinical utility of ultrasensitive circulating tumor DNA detection with CAPP-Seq
  publication-title: Expert Rev Mol Diag
  doi: 10.1586/14737159.2015.1019476
  contributor:
    fullname: Bratman
– volume: 50
  start-page: 2950
  year: 2014
  ident: 10.1016/j.athoracsur.2019.04.004_bib7
  article-title: Prognostic impact of neoadjuvant chemoradiation in cT3 oesophageal cancer—a propensity score matched analysis
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2014.08.020
  contributor:
    fullname: Hölscher
– volume: 366
  start-page: 2074
  year: 2012
  ident: 10.1016/j.athoracsur.2019.04.004_bib8
  article-title: Preoperative chemoradiotherapy for esophageal or junctional cancer
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1112088
  contributor:
    fullname: van Hagen
– volume: 97
  start-page: 142
  year: 2005
  ident: 10.1016/j.athoracsur.2019.04.004_bib1
  article-title: The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/dji024
  contributor:
    fullname: Pohl
– volume: 1
  start-page: 182
  year: 2017
  ident: 10.1016/j.athoracsur.2019.04.004_bib29
  article-title: Patterns of recurrence in oesophageal cancer following oesophagectomy in the era of neoadjuvant chemotherapy
  publication-title: BJS Open
  doi: 10.1002/bjs5.30
  contributor:
    fullname: Knight
– volume: 23
  start-page: 587
  year: 2006
  ident: 10.1016/j.athoracsur.2019.04.004_bib5
  article-title: A survey of oesophageal cancer: pathology, stage and clinical presentation
  publication-title: Aliment Pharmacol Ther
  doi: 10.1111/j.1365-2036.2006.02782.x
  contributor:
    fullname: Schlansky
– volume: 45
  start-page: 478
  year: 2013
  ident: 10.1016/j.athoracsur.2019.04.004_bib22
  article-title: Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
  publication-title: Nat Genet
  doi: 10.1038/ng.2591
  contributor:
    fullname: Dulak
– volume: 27
  start-page: 757
  year: 2014
  ident: 10.1016/j.athoracsur.2019.04.004_bib2
  article-title: Age and sex differences in the incidence of esophageal adenocarcinoma: results from the Surveillance, Epidemiology, and End Results (SEER) registry (1973-2008)
  publication-title: Dis Esophagus
  doi: 10.1111/dote.12147
  contributor:
    fullname: Mathieu
SSID ssj0002155
Score 2.5166092
Snippet Recent literature has demonstrated the potential of “liquid biopsy” and detection of circulating tumor (ct)DNA as a cancer biomarker. However, to date there is...
Recent literature has demonstrated the potential of "liquid biopsy" and detection of circulating tumor (ct)DNA as a cancer biomarker. However, to date there is...
BACKGROUNDRecent literature has demonstrated the potential of "liquid biopsy" and detection of circulating tumor (ct)DNA as a cancer biomarker. However, to...
Background. Recent literature has demonstrated the potential of "liquid biopsy" and detection of circulating tumor (ct)DNA as a cancer biomarker. However, to...
SourceID swepub
pubmedcentral
proquest
crossref
pubmed
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 343
SubjectTerms Adenocarcinoma - blood
Adenocarcinoma - diagnosis
Adenocarcinoma - genetics
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
cancer
Cancer and Oncology
Cancer och onkologi
Cardiovascular System & Cardiology
Circulating Tumor DNA - blood
Circulating Tumor DNA - genetics
diagnosis
Disease Progression
DNA, Neoplasm - genetics
epidemiology
Esophageal Neoplasms - blood
Esophageal Neoplasms - diagnosis
Esophageal Neoplasms - genetics
exome
Female
Humans
Liquid Biopsy
Male
monitor
Mutation
mutations
Neoplasm Staging - methods
patterns
recurrence
Respiratory System
Surgery
survival
Title Detection of Circulating Tumor DNA in Plasma: A Potential Biomarker for Esophageal Adenocarcinoma
URI https://dx.doi.org/10.1016/j.athoracsur.2019.04.004
https://www.ncbi.nlm.nih.gov/pubmed/31059681
https://search.proquest.com/docview/2232130378
https://pubmed.ncbi.nlm.nih.gov/PMC6676214
https://gup.ub.gu.se/publication/282591
Volume 108
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6h9MIFgXiFlxYJcakcxe81nEJbVLVQRSgVva121-vWkWJXjn2AX8-M108lSIGLE238nPky-816HoR8CJgAp0KGVjiPteXZTFkwLbhW5GkpXAEUxMNE4e9Xwfm1d3Hj3_ShvHV2SSln6vfevJL_0SqMgV4xS_YfNNudFAbgO-gXtqBh2B6k41NdatVSvpO0UHUvLvD9V9UmL45Prxa4nLEEgrwRJgV9mZcYHgR6-ZLmGwzNKepAwzPsZgCmBRUGlggmuEKlWd4Y7XUPqb7gcnkH6FGpOt4OMquRm9_-qkyn4lm3LKDXpnXUYGwJFh7YZ2WaaXfD3ypMwjb9qS5mwzUJTINi7ZpEa2dd7F3nj-zsnA0A5QyspmsqNe1Yc7OwsAah1k8Ej4OxeFFdm9Y0Ld5TK_u2uueVhA--1Rwzc7G2wRHWSfQm5Ghx-ePnZTdVA9_x25aKeLtNqJcJANx_1b_xl13_ZDfMdlSMtiYwq8fkUeN50IWB0RPyQGdPieggRPOEDiBEawhRgBBNM2og9IkuaAcg2gGIAoBoDyA6BtAzcv31bHVybjVdNyzlM7fE122SsSiUgWBJnLhACGUSC8eW0hexlFEsbenIMGE6Bn84CJQG0ukrR9jSw-nqOZlkeaZfEqpc2CVwlbSVhAnZF1Hgq2geMzsIXd9LpsRuZcnvTXEV3kYdrnkvf47y53OPg_yn5HMrdN6QREP-OKDmgKPft3riYEfx5ZjIdF5tOdBkB_lcyKbkhdFbd08uOiEBs6ckHGm02wFxN_4lS-_qWu0YQu7YcN2PRvejQ_ZA9dWhO74mD_t_3hsyKYtKvwV-XMp3Dcr_AEOQwnY
link.rule.ids 230,314,780,784,885,27924,27925
linkProvider Library Specific Holdings
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Detection+of+Circulating+Tumor+DNA+in+Plasma%3A+A+Potential+Biomarker+for+Esophageal+Adenocarcinoma&rft.jtitle=The+Annals+of+thoracic+surgery&rft.au=Egyud%2C+M.&rft.au=Tejani%2C+M.&rft.au=Pennathur%2C+A.&rft.au=Luketich%2C+J.&rft.date=2019-08-01&rft.issn=0003-4975&rft.volume=108&rft.issue=2&rft.spage=343&rft_id=info:doi/10.1016%2Fj.athoracsur.2019.04.004&rft.externalDocID=oai_gup_ub_gu_se_282591
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-4975&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-4975&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-4975&client=summon