PINK1 Triggers Autocatalytic Activation of Parkin to Specify Cell Fate Decisions

• Published in: Current biology Vol. 24; no. 16; pp. 1854 - 1865
• Main Authors: Zhang, Conggang, Lee, Schuyler, Peng, Yinghua, Bunker, Eric, Giaime, Emilie, Shen, Jie, Zhou, Zongyao, Liu, Xuedong
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 18.08.2014
• Subjects: Amino Acid Sequence; Apoptosis; Cell Line; Cytoprotection; HEK293 Cells; HeLa Cells; Humans; Phosphorylation; Protein Kinases - genetics; Protein Kinases - metabolism; Sequence Alignment; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination

The PINK1-Parkin pathway is known to play important roles in regulating mitochondria dynamics, motility, and quality control. Activation of this pathway can be triggered by a variety of cellular stress signals that cause mitochondrial damage. How this pathway senses different levels of mitochondrial...